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Characterization of KNDy Neuronal Activity in Gilts: Distribution and Effect of A Progestin
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The role of hypothalamic arcuate nucleus KNDy neurons in control of reproduction in cows
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A population of neurons in the arcuate nucleus (ARC) coexpresses kisspeptin, neurokinin B (NKB), and dynorphin, and therefore they are referred to as KNDy neurons. It has been suggested that KNDy neurons participate in several brain functions, including the control of reproduction.
Hiroaki Okamura +2 more
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In the past decade since kisspeptin/neurokinin B/dynorphin (KNDy) cells were first identified in the mammalian hypothalamus, a plethora of new research has emerged adding insights into the role of this neuronal population in reproductive neuroendocrine function, including the basis for GnRH pulse generation and the mechanisms underlying the steroid ...
Danielle T Porter +2 more
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KNDy neurons as the GnRH pulse generator: Recent studies in ruminants
Peptides, 2023This review considers three aspects of recent work on the role of KNDy neurons in GnRH pulse generation in ruminants. First, work on basic mechanisms of pulse generation includes several tests of this hypothesis, all of which support it, and evidence that Kiss1r-containing neurons form a positive feedback circuit with the KNDy neural network that ...
Casey C, Nestor +4 more
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KNDy Neurons of the Hypothalamus and Their Role in GnRH Pulse Generation: an Update
Endocrinology, 2023Abstract There is considerable evidence that synchronized activity within a reciprocally connected population of cells in the arcuate nucleus (ARC) coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy cells) is crucial for the generation of gonadotrophin-releasing hormone (GnRH) pulses in mammals.
Aleisha M Moore +2 more
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Direct Evidence That KNDy Neurons Maintain Gonadotropin Pulses and Folliculogenesis as the GnRH Pulse Generator [PDF]
Significance Reports suggest that at least 25% of women suffering from reproductive disorders are due to hypothalamic dysfunction. Pulsatile gonadotropin-releasing hormone (GnRH) regimens are used for infertile women.
Naoko Inoue +2 more
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