Results 1 to 10 of about 773,972 (346)

NMN improves cardiac function in SIRT3 knockout mice via the SIRT1/PGC-1α pathway [PDF]

Scientific Reports
SIRT3 knockout mice develop cardiac insufficiency due to decreased mitochondrial function. However, upregulation of the NAD+/NADH ratio can compensate for SIRT3 deficiency through the SIRT1/PGC-1α pathway, thereby improving mitochondrial function.
Xiyao Zhao, Mengrui He, Lina He, Ruijie Han, Yanan Liu   +4 more
doaj   +2 more sources

Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism [PDF]

, 2013
Arginase deficiency is a rare autosomal recessive disorder resulting from a loss of the liver arginase isoform, arginase 1 (ARG1), which is the final step in the urea cycle for detoxifying ammonia. ARG1 deficiency leads to hyperargininemia, characterized
Ballantyne, Laurel L., Funk, Colin D., Kyriakopoulou, Lianna, Mukherjee, Kamalika, Schulze, Andreas, Sin, Yuan Yan, St. Amand, Tim   +6 more
core   +17 more sources

Approaches for timeline reductions in pathogenesis studies using genetically modified mice

Microbiology Spectrum, 2023
Although genetically modified mouse models have long been a powerful tool for microbiology research, the manipulation of the mouse genome is expensive, time consuming, and has historically remained the domain of dedicated animal facilities.
Samantha Skavicus, Nicholas S. Heaton
doaj   +1 more source

Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility [PDF]

Genetics and Molecular Biology, 2014
The mouse testis-enriched Znf230 gene, which encodes a type of RING finger protein, is present primarily in the nuclei of spermatogonia, the acrosome and the tail of spermatozoa.
Yunqiang Liu, Dachang Tao, Yongjie Lu, Yuan Yang, Yongxin Ma, Sizhong Zhang   +5 more
doaj   +3 more sources

Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. [PDF]

PLoS ONE, 2013
The p21-activated kinases are effector proteins for Rho-family GTPases. PAK4, PAK5, and PAK6 are the group II PAKs associated with neurite outgrowth, filopodia formation, and cell survival.
Melody A Furnari, Michelle L Jobes, Tanya Nekrasova, Audrey Minden, George C Wagner   +4 more
doaj   +1 more source

Altered reward circuitry in the norepinephrine transporter knockout mouse. [PDF]

PLoS ONE, 2013
Synaptic levels of the monoamine neurotransmitters dopamine, serotonin, and norepinephrine are modulated by their respective plasma membrane transporters, albeit with a few exceptions.
Joseph J Gallagher, Xiaowei Zhang, F Scott Hall, George R Uhl, Elaine L Bearer, Russell E Jacobs   +5 more
doaj   +1 more source

Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-1 expression in coronary artery endothelium

Frontiers in Physiology, 2023
High levels of low density lipoprotein (LDL) cholesterol and low levels of high density lipoprotein (HDL) cholesterol are risk factors for cardiovascular disease. Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL
Mark T. Fuller, Mark T. Fuller, Omid Dadoo, Omid Dadoo, Ting Xiong, Ting Xiong, Pardh Chivukula, Pardh Chivukula, Melissa E. MacDonald, Samuel K. Lee, Samuel K. Lee, Richard C. Austin, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti, Bernardo L. Trigatti   +15 more
doaj   +1 more source

The Endogenous Alterations of the Gut Microbiota and Feces Metabolites Alleviate Oxidative Damage in the Brain of LanCL1 Knockout Mice

Frontiers in Microbiology, 2020
Altered composition of the gut microbiota has been observed in many neurodegenerative diseases. LanCL1 has been proven to protect neurons and reduce oxidative stress.
Fangxing Zhang, Fangxing Zhang, Fangxing Zhang, Nana Qi, Nana Qi, Nana Qi, Yanyu Zeng, Yanyu Zeng, Yanyu Zeng, Mengying Bao, Mengying Bao, Mengying Bao, Yang Chen, Yang Chen, Jinling Liao, Jinling Liao, Jinling Liao, Luyun Wei, Luyun Wei, Dehao Cao, Dehao Cao, Shengzhu Huang, Shengzhu Huang, Qianqian Luo, Qianqian Luo, Yonghua Jiang, Yonghua Jiang, Yonghua Jiang, Zengnan Mo, Zengnan Mo, Zengnan Mo   +30 more
doaj   +1 more source

Direct Comparison of a Natural Loss-Of-Function Single Nucleotide Polymorphism with a Targeted Deletion in the Ncf1 Gene Reveals Different Phenotypes. [PDF]

PLoS ONE, 2015
The genetic targeting of mouse models has given insight into complex processes. However, phenotypes of genetically targeted mice are susceptible to artifacts due to gene manipulation, which may lead to misinterpretation of the observations.
Outi Sareila, Cecilia Hagert, Pia Rantakari, Matti Poutanen, Rikard Holmdahl   +4 more
doaj   +1 more source

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis [PDF]

, 2013
The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms.
A. Harada, H. Hagiwara, M. Kunii, M. Yuzaki, R. Harada, R. Mizuguchi, S. Matsuda, T. Iwano, T. Sato, Y. Jung, Y. Yoshihara   +10 more
core   +2 more sources