Results 21 to 30 of about 2,060,910 (365)
Arquivos de Neuro-Psiquiatria, 2009 The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice ...
Adriano Tony Ramos +10 more
doaj +1 more source
NeuroSci, 2021 Null mice for the dopamine D2 receptor (D2R) have been instrumental in understanding the function of this protein. For our research, we obtained the functional D2R knockout mouse strain described initially in 1997.
Natalia Sánchez +9 more
doaj +1 more source
Endocrine reviews, 1998 PRL is an anterior pituitary hormone that, along with GH and PLs, forms a family of hormones that probably resulted from the duplication of an ancestral gene.
C. Bôle-Feysot +4 more
semanticscholar +1 more source
Evolutionarily conserved human targets of adenosine to inosine RNA editing [PDF]
Nucleic Acids Research, Vol. 33, 1162-1168 (2005), 2005 A-to-I RNA editing by ADARs is a post-transcriptional mechanism for expanding the proteomic repertoire. Genetic recoding by editing was so far observed for only a few mammalian RNAs that are predominantly expressed in nervous tissues. However, as these editing targets fail to explain the broad and severe phenotypes of ADAR1 knockout mice, additional ...
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2003 The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound transcription factors: sterol regulatory element-binding proteins (SREBP)-1a, -1c, and -2. Their function in liver has been characterized
J. Horton +6 more
semanticscholar +1 more source
The effect of lubricin on the gliding resistance of mouse intrasynovial tendon.
PLoS ONE, 2013 The purpose of this study was to investigate the role of lubricin on the gliding resistance of intrasynovial tendons by comparing lubricin knockout, heterozygous, and wild type mice.
Masanori Hayashi +6 more
doaj +1 more source
Fixing Knockout Tournaments With Seeds [PDF]
Discrete Applied Mathematics, 339:21-35 (2023), 2022 Knockout tournaments constitute a popular format for organizing sports competitions. While prior results have shown that it is often possible to manipulate a knockout tournament by fixing the bracket, these results ignore the prevalent aspect of player seeds, which can significantly constrain the chosen bracket.
arxiv +1 more source
Analysis of microRNA knockouts in mice [PDF]
Human Molecular Genetics, 2010 MicroRNAs (miRNAs) are small noncoding RNAs that act as potent regulators of gene expression. The discovery of miRNAs with specific temporal and spatial expression patterns revealed a hidden layer of post-transcriptional gene regulation. Furthermore, differential expression of miRNAs during disease progression identified miRNAs as relevant candidate ...
Michael T. McManus +2 more
openaire +3 more sources
Scientific Reports, 2014 The CRISPR/Cas system, in which the Cas9 endonuclease and a guide RNA complementary to the target are sufficient for RNA-guided cleavage of the target DNA, is a powerful new approach recently developed for targeted gene disruption in various animal ...
T. Horii +7 more
semanticscholar +1 more source
Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
International Journal of Hypertension, 2012 To elucidate roles of heme oxygenase-1 (HO-1) in cardiovascular system, we have analyzed one-year-old HO-1-knockout mice. Homozygous HO-1-knockout mice had severe aortitis and coronary arteritis with mononuclear cellular infiltration and fatty streak ...
Kazunobu Ishikawa +2 more
doaj +1 more source