Results 31 to 40 of about 2,060,910 (365)
Biology, 2022 AM knockout (AM-/-) and RAMP2 knockout (RAMP2-/-) proved lethal for mice due to impaired embryonic vascular development. Although most vascular endothelial cell-specific RAMP2 knockout (E-RAMP2-/-) mice also died during the perinatal period, a few E ...
Takayuki Shindo +5 more
doaj +1 more source
Arteriosclerosis, Thrombosis and Vascular Biology, 2014 Objective—Deficiency of the high-density lipoprotein receptor, scavenger receptor class B, type I (SR-BI), in apolipoprotein E knockout or hypomorphic mice, respectively, results in spontaneous or diet-inducible occlusive coronary artery (CA ...
M. Fuller +8 more
semanticscholar +1 more source
Myotubularin MTM1 Involved in Centronuclear Myopathy and its Roles in Human and Yeast Cells [PDF]
Journal of Molecular and Genetic Medicine, OMICS International,
2015, 08 (02), 2018 Mutations in the MTM1 gene, encoding the phosphoinositide phosphatase myotubularin, are responsible for the X-linked centronuclear myopathy (XLCNM) or X-linked myotubular myopathy (XLMTM). The MTM1 gene was first identified in 1996 and its function as a PtdIns3P and PtdIns(,5)P2 phosphatase was discovered in 2000.
arxiv +1 more source
Human Genetic Disorders and Knockout Mice Deficient in Glycosaminoglycan
BioMed Research International, 2014 Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective monosaccharides by various glycosyltransferases and maturated by epimerases and sulfotransferases.
Shuji Mizumoto, S. Yamada, K. Sugahara
semanticscholar +1 more source
Rab11a is required for apical protein localisation in the intestine
Biology Open, 2014 The small GTPase Rab11 plays an important role in the recycling of proteins to the plasma membrane as well as in polarised transport in epithelial cells and neurons. We generated conditional knockout mice deficient in Rab11a.
Tomoaki Sobajima +10 more
doaj +1 more source
Bayesian latent hierarchical model for transcriptomic meta-analysis to detect biomarkers with clustered meta-patterns of differential expression signals [PDF]
Ann Appl Stat. 2019 Mar 13(1), 2017 Due to the rapid development of high-throughput experimental techniques and fast-dropping prices, many transcriptomic datasets have been generated and accumulated in the public domain. Meta-analysis combining multiple transcriptomic studies can increase the statistical power to detect disease-related biomarkers.
arxiv +1 more source
Dental and periodontal phenotype in sclerostin knockout mice
International Journal of Oral Science, 2014 Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
U. Kuchler +6 more
semanticscholar +1 more source
Neural Plasticity, 2023 Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa +8 more
doaj +1 more source
Journal of Clinical Investigation, 1993 We employed homologous recombination in embryonic stem cells to produce mice lacking functional LDL receptor genes. Homozygous male and female mice lacking LDL receptors (LDLR-/- mice) were viable and fertile. Total plasma cholesterol levels were twofold
S. Ishibashi +5 more
semanticscholar +1 more source
Endothelial Cell-specific Loss of Breast Cancer Susceptibility Gene 2 Exacerbates Atherosclerosis [PDF]
arXiv, 2023 The BReast CAncer type 2 susceptibility protein (BRCA2) responds to DNA damage by participating in homology-directed repair. BRCA2 deficiency culminates in defective DNA damage repair (DDR) that when prolonged leads to the accumulation of DNA damage causing cancer or apoptosis.
arxiv