Results 51 to 60 of about 773,972 (346)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations

Frontiers in Physiology, 2019
Backgrounds: Recent studies identified heterozygous variants in MYLK3 gene that encodes cardiac myosin light chain kinase (cMLCK) are related to familial dilated cardiomyopathy (DCM) for the first time. Autosomal dominant traits suggest that pathogenesis
Carson L. Tougas, Tabor Grindrod, Lawrence X. Cai, Fariz F. Alkassis, Hideko Kasahara   +4 more
doaj   +1 more source

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors. [PDF]

PLoS ONE, 2015
Antigen-specific IgG antibodies, passively administered to mice or humans together with large particulate antigens like erythrocytes, can completely suppress the antibody response against the antigen.
Joakim J E Bergström, Birgitta Heyman
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

NoxO1 Knockout Promotes Longevity in Mice [PDF]

Antioxidants, 2020
According to the free radical theory of aging, reactive oxygen species (ROS) have been proposed to be a major cause of aging for a long time. Meanwhile, it became clear that ROS have diverse functions in a healthy organism. They act as second messengers, and as transient inhibitors of phosphatases and others.
Tim Schader, Christina Reschke, Manuela Spaeth, Susanne Wienstroer, Szeka Wong, Katrin Schröder   +5 more
openaire   +5 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Gadd45a knockout mice resemble p53 knockouts [PDF]

Genome Biology, 2000
Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.
openaire   +1 more source

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Cdk2 Knockout Mice Are Viable [PDF]

Current Biology, 2003
Cyclin-dependent kinases (Cdks) and their cyclin regulatory subunits control cell growth and division. Cdk2/cyclin E complexes are thought to be required because they phosphorylate the retinoblastoma protein and drive cells through the G1/S transition into the S phase of the cell cycle.
Berthet, Cyril, Aleem, Eiman, Coppola, Vincenzo, Tessarollo, Lino, Kaldis, Philipp   +4 more
openaire   +2 more sources