Results 51 to 60 of about 2,060,910 (365)

Effective polarization in proton-induced $α$ knockout reactions [PDF]

, 2022
The effective polarization of the residual nucleus in the proton-induced $\alpha$ knockout reaction is investigated within the distorted wave impulse approximation framework. The strong absorption of the emitted $\alpha$ particle results in strong selectivity on the reaction "position" depending on the third component of the single-particle orbital ...
arxiv   +1 more source

Integrins in vascular development

Brazilian Journal of Medical and Biological Research, 1999
Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration,
R.O. Hynes, B.L. Bader, K. Hodivala-Dilke   +2 more
doaj   +1 more source

Pdgfrα-Cre mediated knockout of the aryl hydrocarbon receptor protects mice from high-fat diet induced obesity and hepatic steatosis.

PLoS ONE, 2020
Aryl hydrocarbon receptor (AHR) agonists such as dioxin have been associated with obesity and the development of diabetes. Whole-body Ahr knockout mice on high-fat diet (HFD) have been shown to resist obesity and hepatic steatosis.
Francoise A Gourronc, Kathleen R Markan, Katarina Kulhankova, Zhiyong Zhu, Ryan Sheehy, Dawn E Quelle, Leonid V Zingman, Zoya B Kurago, James A Ankrum, Aloysius J Klingelhutz   +9 more
doaj   +1 more source

The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. [PDF]

PLoS ONE, 2014
We previously demonstrated, using osteoblastic MC3T3-E1 cells, that P2Y2 purinergic receptors are involved in osteoblast mechanotransduction. In this study, our objective was to further investigate, using a knockout mouse model, the roles of P2Y2 ...
Yanghui Xing, Yan Gu, James J Bresnahan, Emmanuel M Paul, Henry J Donahue, Jun You   +5 more
doaj   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source

Theoretical estimation of metabolic network robustness against multiple reaction knockouts using branching process approximation [PDF]

Physica A 392, 5525 (2013), 2013
In our previous study, we showed that the branching process approximation is useful for estimating metabolic robustness, measured using the impact degree. By applying a theory of random family forests, we here extend the branching process approximation to consider the knockout of {\it multiple} reactions, inspired by the importance of multiple ...
arxiv   +1 more source

Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases

Genome Research, 2014
RNA-guided endonucleases (RGENs), derived from the prokaryotic Type II CRISPR-Cas system, enable targeted genome modification in cells and organisms. Here we describe the establishment of gene-knockout mice and zebrafish by the injection of RGENs as Cas9
Y. Sung, Jong Min Kim, Hyun-Taek Kim, Jaehoon Lee, Jisun Jeon, Young Jin, Jung-Hwa Choi, Y. Ban, S. Ha, Cheol-Hee Kim, Han-Woong Lee, Jin-Soo Kim   +11 more
semanticscholar   +1 more source

Ovol2, a zinc finger transcription factor, is dispensable for spermatogenesis in mice

Reproductive Biology and Endocrinology, 2019
Ovol2, a mouse homolog of Drosophila ovo, was identified as a zinc finger transcription factor predominantly expressed in testis. However, the function of Ovol2 in postnatal male germ cell development remains enigmatic. Here, we firstly examined the mRNA
Jin Zhang, Juan Dong, Weibing Qin, Congcong Cao, Yujiao Wen, Yunge Tang, Shuiqiao Yuan   +6 more
doaj   +1 more source

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Effects of Fscb/Cabyr double gene knockout on reproductive capacity in male mice

Di-san junyi daxue xuebao, 2021
Objective To evaluate the value of CABYR protein and its complex with FSCB in maintaining sperm fertilization ability and investigate the possible mechanism of physiological function of the coruplex by observing the natural fertility of Fscb/Cabyr double
LI Zhongtai, LI Zhongtai, LI Yanfeng, LIU Jinyi, ZHANG Yong, ZHANG Jun, BI Gang   +6 more
doaj   +1 more source