Results 41 to 50 of about 46,456 (156)
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. [PDF]
PLoS ONE, 2013 Fumarate hydratase (FH)-deficient kidney cancer undergoes metabolic remodeling, with changes in mitochondrial respiration, glucose, and glutamine metabolism.
Youfeng Yang +11 more
doaj +1 more source
Nature Communications, 2019 The mechanisms associated with fatty acid synthase (FASN) upregulation during transformation are unclear. Here, the authors report that FASN promotes anaplerotic shift of the Krebs cycle in cancer cells expressing various oncogenes, and that its ...
Maria J. Bueno +12 more
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Nature Communications, 2017 Divalent anion/Na+ symporter (DASS) transporters move intermediates of the Krebs cycle across the cell membrane. Here the authors present the substrate-bound structures of VcINDY, a DASS from Vibrio cholerae, which provide insights into the underlying ...
Rongxin Nie +4 more
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Metabolomic Profiling Reveals PGPR-Driven Drought Tolerance in Contrasting Brassica juncea Genotypes
MetabolitesBackground: Drought stress is a major abiotic factor limiting Brassica juncea productivity, resulting in significant yield reductions. Plant Growth-Promoting Rhizobacteria (PGPR) have shown potential in enhancing drought tolerance; however, the ...
Asha Rani Sheoran +7 more
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Krebs cycle anions in metabolic acidosis.
Critical care (London, England), 2005 For many years it has been apparent from estimates of the anion gap and the strong ion gap that anions of unknown identity can be generated in sepsis and shock states. Evidence is emerging that at least some of these are intermediates of the citric acid cycle.
Bowling, Francis G, Morgan, Thomas J
openaire +2 more sources
Molecular Cancer, 2009 Background Metabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analysis of gene dysregulations in ...
Higashi Richard M +6 more
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NFS Journal, 2020 Introduction: Psidium friedrichsthalianum fruits have in vitro antioxidant activity and their intake has been suggested to have potential health benefits; however, there is still no evidence on the potential in vivo effect of their consumption. Objective:
Alexander Montoya-Arroyo +3 more
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The role of INDY in metabolism, health & longevity.
Frontiers in Genetics, 2015 Indy (I’m Not Dead Yet) encodes the fly homolog of a mammalian SLC13A5 plasma membrane transporter. INDY is expressed in metabolically active tissues functioning as a transporter of Krebs cycle intermediates with the highest affinity for citrate ...
Ryan P. Rogers, Blanka eRogina
doaj +1 more source
Conversion of glutamate carbon to fatty acid carbon via citrate in rat epididymal fat pads
Journal of Lipid Research, 1964 The incorporation of the C14 of glutamate-2-C14 and glutamate-5-C14 into fatty acids by epididymal fat pads and liver slices suggests the operation of the following metabolic pathway: α-ketoglutarate → isocitrate → cis-aconitate → citrate → acetyl CoA ...
J. Madsen, S. Abraham, I.L. Chaikoff
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Illuminating mitochondrial metabolism with genetically encoded fluorescent indicators
Biosensors and Bioelectronics: XMitochondria are recognized as dynamic metabolic hubs that integrate bioenergetic, biosynthetic and signaling functions well beyond ATP production. Their matrix hosts the Krebs cycle, fatty acid β-oxidation, and key branches of amino-acid metabolism ...
C. Aburto +3 more
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