Comparison of the effect of the aerobic glycolysis inhibitor dichloroacetate and of the Krebs cycle inhibitor LW6 on cellular and humoral alloimmunity. [PDF]
Biomed Rep, 2017 Eleftheriadis T +4 more
europepmc +3 more sources
Nature Communications, 2023 Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular at the organism level.
Eunah Kim +13 more
doaj +1 more source
The role of itaconate in host defense and inflammation
The Journal of Clinical Investigation, 2022 Macrophages exposed to inflammatory stimuli including LPS undergo metabolic reprogramming to facilitate macrophage effector function. This metabolic reprogramming supports phagocytic function, cytokine release, and ROS production that are critical to ...
Christian G. Peace, Luke A.J. O’Neill
doaj +1 more source
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]
, 2005 Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap.
Forni, L.G. +5 more
core +2 more sources
Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage [PDF]
International Journal of Rheumatology, 2016 This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage.
Elena V. Tchetina +6 more
openalex +2 more sources
Fluxomics of the Eastern Oyster for Environmental Stress Studies
Metabolites, 2014 The metabolism of 2-13C/15N-glycine and U-13C-glucose was determined in four tissue blocks (adductor muscle, stomach and digestive gland, mantle, and gills) of the Eastern oyster (Crassostrea virginica) using proton (1H) and carbon-13 (13C) nuclear ...
Andrey P. Tikunov +2 more
doaj +1 more source
Frontiers in Plant Science, 2014 Environmental changes such as early spring and warm spells induce bud burst and photosynthetic processes in cold-acclimated coniferous trees and consequently, cellular metabolism in overwintering needles and buds.
Priyanka eDhuli +2 more
doaj +1 more source
Minimizing acetate formation in E. coli fermentations [PDF]
, 2007 Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie +3 more
core +2 more sources
Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity [PDF]
, 2011 The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) enhances oxidative metabolism in skeletal muscle. Excessive lipid oxidation and electron transport chain activity can, however, lead to the accumulation of harmful metabolites and ...
Handschin, C. +3 more
core +1 more source
Acta Scientiarum: Biological Sciences, 2012 The southern State of Rio Grande do Sul (RS) is the main rice producer in Brazil with a 60% participation of the national production and 86% participation of the region. Rice culture irrigation system is done by flooding, which leads to soil salinization,
Maria da Graça de Souza Lima +5 more
doaj +1 more source