Results 1 to 10 of about 19,477 (272)

Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]

Biomolecules
In this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran, Marcelin Jan Pietryja, Berthold Kepplinger   +2 more
doaj   +2 more sources

Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis [PDF]

Scientific Reports, 2020
Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired.
Hisayuki Erabi, Go Okada, Chiyo Shibasaki, Daiki Setoyama, Dongchon Kang, Masahiro Takamura, Atsuo Yoshino, Manabu Fuchikami, Akiko Kurata, Takahiro A. Kato, Shigeto Yamawaki, Yasumasa Okamoto   +11 more
doaj   +2 more sources

Effects of kynurenic acid on cardiovascular system

Journal of Education, Health and Sport, 2017
Kynurenic Acid (KYNA) is an endogenous metabolite of tryptophan (TRP) which is produced by aminotransferase KAT I and KAT II in the central nervous system and peripheral tissues. Moreover it has been shown that it can be supplied with food.
Piotr Kozłowski, Magdalena Kozłowska, Karolina Kozłowska   +2 more
doaj   +4 more sources

Novel Activity of Oral Hypoglycemic Agents Linked with Decreased Formation of Tryptophan Metabolite, Kynurenic Acid [PDF]

Life
Kynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz, Kamila Kozieł, Ewa M. Urbańska   +2 more
doaj   +2 more sources

Selective heterofunctionalization of kynurenic acid derivatives. [PDF]

RSC Adv
The current study presents selective halogenation of kynurenic acid analogues and further transformation thereof.
Törteli L, Simon P, Berkecz R, Szatmári I.   +3 more
europepmc   +2 more sources

Cytotoxic Effects of Kynurenic Acid and Quinaldic Acid in Hepatocellular Carcinoma (HepG2) Cell Line [PDF]

Proceedings, 2017
Kynurenic acid (KYNA), tryptophan metabolite synthesized in the kynurenine pathway, is present in human body fluids as well as in variety of foods, herbal medicines and honeybee derived foodstuffs.
Pınar Atalay Dündar, N. Nalan İmamoğlu   +1 more
doaj   +2 more sources

Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]

Molecules
Kynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz   +5 more
doaj   +2 more sources

The Metabolism of Kynurenic Acid

Journal of Biological Chemistry, 1961
Kengo Horibata, Hiroshi Taniuchi, Minoru Tashiro, Sigeru Kuno, Osamu Hayaishi   +4 more
openalex   +4 more sources

The Metabolism of Quinaldic Acid, Kynurenic Acid, and Xanthurenic Acid in the Rabbit

Journal of Biological Chemistry, 1962
Masako Kaihara, J. M. Price
openalex   +3 more sources

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier

Pharmaceutics, 2021
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár, Bálint Lőrinczi, Csilla Fazakas, István Szatmári, Ferenc Fülöp, Noémi Kmetykó, Róbert Berkecz, István Ilisz, István A. Krizbai, Imola Wilhelm, László Vécsei   +10 more
doaj   +1 more source