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Novel Activity of Oral Hypoglycemic Agents Linked with Decreased Formation of Tryptophan Metabolite, Kynurenic Acid [PDF]

open access: yesLife
Kynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz   +2 more
doaj   +3 more sources

Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis [PDF]

open access: goldScientific Reports, 2020
Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired.
Hisayuki Erabi   +11 more
doaj   +3 more sources

The microbial production of kynurenic acid using Yarrowia lipolytica yeast growing on crude glycerol and soybean molasses

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Yarrowia lipolytica yeast are able to produce kynurenic acid—a very valuable compound acting as a neuroprotective and antioxidant agent in humans. The recent data proved the existence of the kynurenine biosynthesis pathway in this yeast cells.
Magdalena Rakicka-Pustułka   +5 more
doaj   +2 more sources

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier

open access: yesPharmaceutics, 2021
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár   +10 more
doaj   +2 more sources

Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

open access: yesThe Journal of Headache and Pain, 2021
Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker   +7 more
doaj   +2 more sources

A Review of the Health Benefits of Food Enriched with Kynurenic Acid. [PDF]

open access: yesNutrients, 2022
Kynurenic acid (KYNA), a metabolite of tryptophan, is an endogenous substance produced intracellularly by various human cells. In addition, KYNA can be synthesized by the gut microbiome and delivered in food.
Turska M   +3 more
europepmc   +2 more sources

Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]

open access: yesBiomolecules
In this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran   +2 more
doaj   +2 more sources

Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients [PDF]

open access: goldBiomolecules, 2020
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD).
Marta González‐Sánchez   +15 more
openalex   +2 more sources

Albumin-bound kynurenic acid is an appropriate endogenous biomarker for assessment of the renal tubular OATs-MRP4 channel [PDF]

open access: yesJournal of Pharmaceutical Analysis, 2023
Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug and toxin excretion. Unfortunately, there are no biomarkers to evaluate their function.
Yanrong Ma   +5 more
doaj   +2 more sources

Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation Is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104 [PDF]

open access: goldInternational Journal of Molecular Sciences, 2020
Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system. Since glutamate and microglia are important in the pathogenesis of epilepsy, we investigated the possible action of the synthetic kynurenic
Noémi Lajkó   +9 more
openalex   +2 more sources

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