Results 1 to 10 of about 5,030,463 (208)

Novel Activity of Oral Hypoglycemic Agents Linked with Decreased Formation of Tryptophan Metabolite, Kynurenic Acid [PDF]

Life
Kynurenic acid is a tryptophan (Trp) metabolite formed along the kynurenine (KYN) pathway in the brain and in peripheral tissues. The disturbed formation of kynurenic acid, which targets glutamate-mediated neurotransmission, GPR35, and aryl hydrocarbon ...
Kinga Bednarz, Kamila Kozieł, Ewa M. Urbańska   +2 more
doaj   +3 more sources

The microbial production of kynurenic acid using Yarrowia lipolytica yeast growing on crude glycerol and soybean molasses

Frontiers in Bioengineering and Biotechnology, 2022
Yarrowia lipolytica yeast are able to produce kynurenic acid—a very valuable compound acting as a neuroprotective and antioxidant agent in humans. The recent data proved the existence of the kynurenine biosynthesis pathway in this yeast cells.
Magdalena Rakicka-Pustułka, Patrycja Ziuzia, Jan Pierwoła, Kacper Szymański, Magdalena Wróbel-Kwiatkowska, Zbigniew Lazar   +5 more
doaj   +2 more sources

SZR-104, a Novel Kynurenic Acid Analogue with High Permeability through the Blood–Brain Barrier

Pharmaceutics, 2021
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the ...
Kinga Molnár, Bálint Lőrinczi, Csilla Fazakas, István Szatmári, Ferenc Fülöp, Noémi Kmetykó, Róbert Berkecz, István Ilisz, István A. Krizbai, Imola Wilhelm, László Vécsei   +10 more
doaj   +2 more sources

Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid

The Journal of Headache and Pain, 2021
Background The topical inflammatory soup can model the inflammation of the dura mater causing hypersensitivity and activation of the trigeminal system, a phenomenon present in migraineurs.
Eleonóra Spekker, Klaudia Flóra Laborc, Zsuzsanna Bohár, Gábor Nagy-Grócz, Annamária Fejes-Szabó, Mónika Szűcs, László Vécsei, Árpád Párdutz   +7 more
doaj   +2 more sources

The Biology and Biochemistry of Kynurenic Acid, a Potential Nutraceutical with Multiple Biological Effects. [PDF]

Int J Mol Sci
Kynurenic acid (KYNA) is an antioxidant degradation product of tryptophan that has been shown to have a variety of cytoprotective, neuroprotective and neuronal signalling properties.
Alves LF, Moore JB, Kell DB.
europepmc   +2 more sources

Importance of Modulating Kynurenic Acid Metabolism—Approaches for the Treatment of Dementia [PDF]

Biomolecules
In this article, we focus on kynurenic acid metabolism in neuropsychiatric disorders and the biochemical processes involved in memory and cognitive impairment, followed by different approaches in the fight against dementia.
Halina Baran, Marcelin Jan Pietryja, Berthold Kepplinger   +2 more
doaj   +2 more sources

Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis

Scientific Reports, 2020
Since optimal treatment at an early stage leads to remission of symptoms and recovery of function, putative biomarkers leading to early diagnosis and prediction of therapeutic responses are desired.
Hisayuki Erabi, Go Okada, Chiyo Shibasaki, Daiki Setoyama, Dongchon Kang, Masahiro Takamura, Atsuo Yoshino, Manabu Fuchikami, Akiko Kurata, Takahiro A. Kato, Shigeto Yamawaki, Yasumasa Okamoto   +11 more
doaj   +2 more sources

Synthesis of New C-3 Substituted Kynurenic Acid Derivatives

Molecules, 2020
The application of kynurenic acid (KYNA) as an electron-rich aromatic system in the modified Mannich reaction has been examined. The extension possibility of the reaction was tested by using amines occurring in a number of bioactive products, such as ...
Bálint Lőrinczi, Antal Csámpai, Ferenc Fülöp, István Szatmári   +3 more
doaj   +2 more sources

Determination of Bioactive Compound Kynurenic Acid in Linum usitatissimum L. [PDF]

Molecules
Kynurenic acid (KYNA) is a bioactive compound exhibiting multiple actions and positive effects on human health due to its antioxidant, anti-inflammatory and neuroprotective properties.
Magdalena Wróbel-Kwiatkowska, Waldemar Turski, Grażyna Silska, Magdalena Rakicka-Pustułka, Lucyna Dymińska, Waldemar Rymowicz   +5 more
doaj   +2 more sources

Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease

Alzheimer's & Dementia, 2023
The kynurenine pathway's (KP) malfunction is closely related to Alzheimer's disease (AD), for antagonistic kynurenic acid (KA) and agonistic quinolinic acid act on the N‐methyl‐D‐aspartate receptor, a possible therapeutic target in treating AD.
Anne-Brita Knapskog, Mari Aksnes, T. H. Edwin, Per Magne Ueland, A. Ulvik, Evandro Fei Fang, R. Eldholm, N. Halaas, I. Saltvedt, Lasse M. Giil, L. Watne   +10 more
semanticscholar   +1 more source