Results 111 to 120 of about 5,018,081 (294)

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations. [PDF]

PLoS ONE, 2011
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast
Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw   +7 more
doaj   +1 more source

Neuroimmune pathophysiology of long COVID

Psychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen, Christopher A. Baker, Akiko Iwasaki   +2 more
wiley   +1 more source

elPBN neurons regulate rVLM activity through elPBN-rVLM projections during activation of cardiac sympathetic afferent nerves. [PDF]

, 2016
The external lateral parabrachial nucleus (elPBN) within the pons and rostral ventrolateral medulla (rVLM) contributes to central processing of excitatory cardiovascular reflexes during stimulation of cardiac sympathetic afferent nerves (CSAN).
Fu, Liang-Wu, Guo, Zhi-Ling, Longhurst, John C, Tjen-A-Looi, Stephanie C   +3 more
core   +1 more source

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short‐term plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Neurotransmitter release was characterized at post‐hearing rat calyx of Held synapses, before and after pharmacologically augmenting synaptic strength, by recording unitary EPSCs, or capacitance changes in response to presynaptic step depolarizations.
Kun‐Han Lin, Mrinalini Ranjan, Noa Lipstein, Nils Brose, Erwin Neher, Holger Taschenberger   +5 more
wiley   +1 more source

Brain‐Specific Modulation of Kynurenic Acid Synthesis in the Rat [PDF]

Journal of Neurochemistry, 1997
Abstract: This study was designed to investigate modulatory mechanisms that control the synthesis of the neuroprotective endogenous excitatory amino acid receptor antagonist kynurenate. De novo kynurenate formation was examined in vitro using tissue slices from rat brain, liver, and kidney. In slices from adult cerebral cortex, veratridine, quisqualate,
Gramsbergen, J B, Hodgkins, P S, Rassoulpour, A, Turski, W A, Guidetti, P, Schwarcz, R   +5 more
openaire   +4 more sources

Fighting obesity by targeting factors regulating beige adipocytes. [PDF]

, 2018
Purpose of reviewThe current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.Recent findingsWe outline recent studies ...
Koliwad, Suneil K, McQueen, Allison E, Wang, Jen-Chywan   +2 more
core   +1 more source

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. [PDF]

, 2009
A principal objective of spinal cord injury (SCI) research is the restoration of axonal connectivity to denervated targets. We tested the hypothesis that chemotropic mechanisms would guide regenerating spinal cord axons to appropriate brainstem targets ...
Alto, Laura Taylor, Blesch, Armin, Conner, James M, Havton, Leif A, Hollis, Edmund R, Tuszynski, Mark H   +5 more
core   +2 more sources

Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex

The Journal of Physiology, EarlyView.
Abstract figure legend Basket cells represent critical building blocks of neuronal circuits in cortical regions by providing GABAergic innervation to the perisomatic region of their postsynaptic partners. In the mouse prelimbic cortex, the two basket cell types expressing parvalbumin or cholecystokinin/type I cannabinoid receptor receive unitary ...
Zsuzsanna Fekete, Filippo Weisz, Mária Rita Karlócai, Judit M. Veres, Tibor Andrási, Norbert Hájos   +5 more
wiley   +1 more source

Photochemistry of aqueous solutions of kynurenic acid and kynurenine yellow [PDF]

Photochemical & Photobiological Sciences, 2013
The photophysics and photochemistry of kynurenic acid (KNA) and kynurenine yellow (KNY) in neutral aqueous solutions were investigated using time-resolved optical spectroscopy. Both molecules have similar quinoline-like structures, the only difference being the absence of conjugation in the nitrogen containing cycle in KNY.
Robert Kaptein, Robert Kaptein, Yuri P. Tsentalovich, Eric Vauthey, Olga A. Snytnikova, Peter S. Sherin, Ekaterina A. Zelentsova   +6 more
openaire   +4 more sources

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source