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Immunology, Volume 175, Issue 4, Page 453-466, August 2025.Antibiotic‐induced dysbiosis of the gut microbiota shifts host tryptophan metabolism and impairs the innate immune response during Pseudomonas aeruginosa pulmonary infection. (A) Eubiosis: During eubiosis, the intestinal microbiota metabolises tryptophan into indole metabolites, which keeps tryptophan levels within normal serum concentrations. However,
Camila Bernardo de Brito +19 more
wiley +1 more source
Kynurenine 3-Monooxygenase: An Influential Mediator of Neuropathology [PDF]
, 2015 Mounting evidence demonstrates that kynurenine metabolism may play an important pathogenic role in the development of multiple neurological and neuropsychiatric disorders.
Jason C. O’Connor, Jennifer M. Parrott
core +5 more sources
Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
Oxidative Medicine and Cellular Longevity, 2018 The catabolism of tryptophan has gained great importance in recent years due to the fact that the metabolites produced during this process, with neuroactive and redox properties, are involved in physiological and pathological events.
L. A. Ramos-Chávez +8 more
semanticscholar +1 more source
Food Science &Nutrition, Volume 13, Issue 7, July 2025.Complex interventions significantly prevent the depression‐like behaviors. Nutrient‐synbiotic complex presents the more beneficial effects. Nutrient‐synbiotic complex modifies the composition of gut microbial community. Nutrient‐synbiotic complex improves the tryptophan metabolic homeostasis.
Zhipeng Liu +7 more
wiley +1 more source
The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice [PDF]
, 2018 BACKGROUND: The orphan receptor G protein–coupled receptor 35 (GPR35) has been associated with a range of diseases, including cancer, inflammatory bowel disease, diabetes, hypertension, and heart failure.
Divorty, Nina +3 more
core +1 more source
Kynurenic acid as the neglected ingredient of commercial baby formulas
Scientific Reports, 2019 The global increase in resorting to artificial nutritional formulas replacing breastfeeding has been identified among the complex causes of the obesity epidemic in infants and children.
P. Milart +12 more
semanticscholar +1 more source
p‐Cresol and p‐Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.ABSTRACT Recent studies have emphasized the significant role of p‐cresol and its conjugated form, p‐cresyl sulphate (PCS), in enhancing oxidative stress, leading to potential detrimental effects on various biological systems. Both p‐cresol and PCS contribute to increased production of reactive oxygen species (ROS), which can result in tissue damage ...
Rinvil Renaldi +3 more
wiley +1 more source
Journal of Diabetes Research, 2019 Patients with diabetes mellitus (DM) type 1 and 2 are at a higher risk of cognitive decline and dementia; however, the underlying pathology is poorly understood.
Iwona Chmiel-Perzyńska +5 more
doaj +1 more source
Journal of Apicultural Science, 2020 The aim of this study was to determine the phytochemical content of Moroccan Jujube Honey and to establish the principal components of this staple Moroccan food, which contributes health benefit for the local population.
Khallouki Farid +4 more
doaj +1 more source
Role of pressor mechanisms from the NTS and CVLM in control of arterial pressure [PDF]
, 2005 In the present study, we investigated the effects of inhibition of the caudal ventrolateral medulla (CVLM) with the GABA(A) agonist muscimol combined with the blockade of glutamatergic mechanism in the nucleus of the solitary tract (NTS) with kynurenic ...
Colombari, Eduardo +4 more
core +1 more source