Results 101 to 110 of about 48,449 (279)

Tryptophan regulates the expression of IGFBP1 in bovine endometrial epithelial cells in vitro via the TDO2-AHR pathway

open access: yesBMC Veterinary Research
Background This study aimed to identify the roles of L-tryptophan (Trp) and its rate-limiting enzymes on the receptivity of bovine endometrial epithelial cells. Real-time PCR was conducted to analyze the differential expression of genes between different
Peng-Chao Wang   +8 more
doaj   +1 more source

Metabolite changes in blood predict the onset of tuberculosis

open access: yes, 2018
Immunogenetics and cellular immunology of bacterial infectious ...
Boom, W.H.   +21 more
core   +1 more source

Metabolomic Profiling of Probiotic Lactobacillus acidophilus Strain LA01 on Bovine Bone Powder Fermentation

open access: yesFood Chemistry International, EarlyView.
Probiotic Lactobacillus acidophilus strain LA01 was applied to bone powder fermentation. The adsorbable calcium, small peptides, and compounds with lipid‐lowering and antioxidant properties were greatly enriched. This study provided insights into the metabolism of probiotic fermentation and laid the scientific basis for development of value‐added ...
Ruijie Zhang   +3 more
wiley   +1 more source

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

open access: yesEuropean Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Slovák L.   +5 more
doaj   +1 more source

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target [PDF]

open access: yes, 2018
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years.
Abdel-Aziz   +431 more
core   +2 more sources

Renoprotective Effect of Coix lachryma‐jobi L. Seed Polysaccharides in Adenine‐Induced Chronic Renal Failure by Blocking Gut Urea Metabolism

open access: yesFood Frontiers, EarlyView.
ABSTRACT Dietary soluble fiber may alleviate renal damage in chronic kidney disease (CKD) by promoting intestinal urea excretion, though the underlying mechanisms remain unclear. This study investigated the digestion, fermentation, and renoprotective effects of Coix lachryma‐jobi L.
Hongmei Yin   +9 more
wiley   +1 more source

Stimulatory effect of repeated treatment with lipopolysaccharide on a key enzyme of the kynurenine pathway in both genders in rats

open access: yesEuropean Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj   +1 more source

Kynurenine pathway metabolites and suicidality

open access: yesNeuropharmacology, 2017
Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood.
Lena Brundin, Elena Y. Bryleva
openaire   +3 more sources

Deamidation at Asparagine and Glutamine As a Major Modification upon Deterioration/Aging of Proteinaceous Binders in MuralPaintings [PDF]

open access: yes, 2011
Proteomic strategies are herein proved to be a complementary approach to the well established amino acid composition analysis for the characterization of the aging and deterioration phenomena occurring to proteinaceous materials in works-of-art.
A. Andreotti   +6 more
core   +1 more source

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure

open access: yesiMetaOmics, EarlyView.
Microplastic‐induced gut microbial enrichment was dominated by bacteria within Eubacteriales, correlated with the virome, and accompanied by colitis. The polyamine synthetic pathway was activated to maintain glutathionylspermidine homeostasis, concurrent with decreases in pathways involved in the production of energy and reactive oxygen species under ...
Guozhu Ye   +6 more
wiley   +1 more source

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