Results 101 to 110 of about 40,027 (305)

Searching for Peripheral Biomarkers in Neurodegenerative Diseases: The Tryptophan-Kynurenine Metabolic Pathway

International Journal of Molecular Sciences, 2020
Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex which develops into a certain clinical picture. The pathogenesis and disease course vary from patient to patient.
N. Török, Masaru Tanaka, L. Vécsei
semanticscholar   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +1 more source

Peer Review #2 of "Targeted metabolomics suggests a probable role of the FTO gene in the kynurenine pathway in prediabetes (v0.1)"

, 2022

openalex   +1 more source

THE KYNURENINE PATHWAY AND ITS ROLE IN GLIOBLASTOMA CELL MIGRATION [PDF]

, 2023
Diana Sirnikova, Jóhannes Reynisson, Anke Brüning‐Richardson, Catherine Kirby   +3 more
openalex   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Involvement of Kynurenine Pathway Between Inflammation and Glutamate in the Underlying Etiopathology of CUMS-Induced Depression Mouse Model [PDF]

, 2022
Xingying Wu, Bowen Chen, Di Zhong, Shuo Jiang, Haipeng Xu, Mengting Shi, Rong Hu, Shaopeng Sun, Zhujin Song, Jiapeng Liu, Ruijie Ma, Qin Guo   +11 more
openalex   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

Deep Learning Model Enables the Discovery of a Novel Immunotherapeutic Agent Regulating the Kynurenine Pathway [PDF]

, 2021
Jeong Hun Kim, Won Suk Lee, Hye Jin Lee, Hannah Yang, Seung Joon Lee, So Jung Kong, Soyeon Je, Hyun‐Jin Yang, Jongsun Jung, Jae Kyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim   +12 more
openalex   +1 more source

The role of kynurenine and kynurenine metabolites in psoriasis

Turkish Journal of Biochemistry
Abstract Objectives Psoriasis is a widespread immunological disease characterised by inflammation and primarily associated with skin and joint symptoms. The kynurenine pathway significantly influences inflammation and immune system activity.
Fikret Akyurek, Fatma Tuncez-Akyurek, Fatma Sengul   +2 more
openaire   +2 more sources