Results 111 to 120 of about 55,792 (321)

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

Kynurenines, neurodegeneration and Alzheimer’s disease [PDF]

Journal of Cellular and Molecular Medicine, 2010
Abstract Alzheimer’s disease The kynurenine pathway Relations of kynurenines to the pathomechanism of AD A future therapeutic approach: modulating the kynurenine pathway Concluding remarks Alzheimer’s disease (AD) is one of the major causes of dementia. The pathogenesis of the disease is not entirely understood, but the amyloid β peptide (Aβ) and the
Kincses Zsigmond Tamás, Toldi József, Vécsei László   +2 more
openaire   +4 more sources

The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy
Introduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili, Alina Seryogina, Mira Beisembayeva, Shynar Muratbekova, Ivan Turkevich, Yelena Shayakhmetova   +5 more
doaj   +1 more source

Plant Hormones Differentially Control the Sub-Cellular Localization of Plasma Membrane Microdomains during the Early Stage of Soybean Nodulation [PDF]

, 2019
Phytohormones regulate the mutualistic symbiotic interaction between legumes and rhizobia, nitrogen-fixing soil bacteria, notably by controlling the formation of the infection thread in the root hair (RH).
Libault, Marc, Qiao, Zhenzhen, Zogli, Prince   +2 more
core   +1 more source

Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma [PDF]

, 2020
Uveal melanoma (UM) is the most common primary eye malignancy in adults and up to 50% of patients subsequently develop systemic metastasis. Metastatic uveal melanoma (MUM) is highly resistant to immunotherapy.
Bhushan, Alok, Kaushal, Gagan, Lam, Bao, Link, Emma, Londin, Eric R, Orloff, Marlana, Rochani, Ankit, Sato, Takami, Terai, Mizue   +8 more
core   +1 more source

Metabolomics Identifies multiple candidate biomarkers to diagnose and stage human African trypanosomiasis [PDF]

, 2016
Treatment for human African trypanosomiasis is dependent on the species of trypanosome causing the disease and the stage of the disease (stage 1 defined by parasites being present in blood and lymphatics whilst for stage 2, parasites are found beyond the
Barrett, Michael P., Bisser, Sylvie, Biéler, Sylvain, Cattanach, Amy M., Courtioux, Bertrand, Daly, Rónán, Ndung’u, Joseph M., Vincent, Isabel M.   +7 more
core   +4 more sources

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

ESC Heart Failure, EarlyView.
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem, Teresa C. Leone, Christopher Petucci, Clarissa Shoffler, Ravindra C. Kodihalli, Tiffany Hidalgo, Cheryl Tow‐Keogh, Jessica Mancuso, Iphigenia Tzameli, Donald Bennett, John D. Groarke, Rachel J. Roth Flach, Daniel J. Rader, Daniel P. Kelly   +13 more
wiley   +1 more source

Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate‐mediated pathway

European Journal of Heart Failure, EarlyView.
Aims Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro.
David M. Kaye, Xiao Suo Wang, Yen Chin Koay, Mengbo Li, Bailey McIntosh, Yann Huey Ng, Michael Rahman, Yiyang Cao, Francine Z. Marques, Cassandra Malecki, Shane Nanayakkara, Justin Mariani, Bing Wang, Sean Lal, Giovanni Guglielmi, John F. O'Sullivan   +15 more
wiley   +1 more source

Serum levels and removal by haemodialysis and haemodiafiltration of tryptophan-derived uremic toxins in ESKD patients [PDF]

, 2020
Tryptophan is an essential dietary amino acid that originates uremic toxins that contribute to end-stage kidney disease (ESKD) patient outcomes.
Adoberg, A, Arduan Ortiz, A, Arund, J, Dhondt, Annemieke, Fernström, A, Fridolin, I, Glorieux, Griet, Gonzales-Parra, E, Leis, L, Luman, M, Paats, J, Perez-Gomez, VM, Pilt, K, Sanchez-Ospina, D, Segelmark, M, Uhlin, F   +15 more
core   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source