Results 111 to 120 of about 48,449 (279)

Kynurenine metabolism in health and disease

Amino Acids, 2010
Kynurenine is a small molecule derived from tryptophan when this amino acid is metabolised via the kynurenine pathway. The biological activity of kynurenine and its metabolites (kynurenines) is well recognised. Therefore, understanding the regulation of the subsequent biochemical reactions is essential for the design of therapeutic strategies which aim
Kolodziej, L, Paleolog, E, Williams, R
openaire   +4 more sources

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents : a cross-sectional analysis of two cohorts [PDF]

, 2018
Background: Tryptophan breakdown is an important mechanism in several diseases e.g. inflammation and stress induced inflammation have been associated with the development of depression via enhanced tryptophan breakdown.
Carvalho, Livia A, Clarke, Gerard, Díaz, Ligia Esperanza, Gómez-Martínez, Sonia, Marcos, Ascensión, Michels, Nathalie, Olavarria-Ramirez, Loreto, Widhalm, Kurt   +7 more
core   +2 more sources

Synergistic effects of Bifidobacterium longum subsp. infantis B8762 and milk‐derived osteopontin on male reproductive health in mice

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Male reproductive health is intricately linked to dietary components and gut microbiota balance. Osteopontin (OPN) deficiency and gut dysbiosis are associated with impaired spermatogenesis, yet the synergistic effects of probiotics and OPN remain unexplored.
Chunyan Zhao, Guangqi Gao, Tao Zhang, Na Li, Yue Zhao, Zerong Lu, Yong Zhang, Zhihong Sun   +7 more
wiley   +1 more source

The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway [PDF]

, 2013
Gut granules are lysosome-like organelles with acidic interiors that are found in large numbers within the intestine of the nematode Caenorhabditis elegans.
Coburn, C, Gems, D
core   +2 more sources

Systematic Review with Meta‐Analysis of Biofluid Markers for Huntington's Disease

Movement Disorders, EarlyView.
Eight Huntington's Disease Biofluid Markers show Meta‐Analytic Significance Across HD‐ISS Stages. Meta‐analyses were conducted for two types of biomarkers: Different from demographically‐matched healthy controls and *Showing change over time. Abstract Primary therapeutic objectives for Huntington's disease (HD) necessitate continued therapy for a long ...
Jane S. Paulsen, Natalie A. Bovin, Jordan D. Clemsen, Alexander Weiss, Abigail M. Key, Monica L. Janz, Alex Pinto, Deven K. Burks, Henrik Zetterberg, Kathleen M. Shannon   +9 more
wiley   +1 more source

Plant Hormones Differentially Control the Sub-Cellular Localization of Plasma Membrane Microdomains during the Early Stage of Soybean Nodulation [PDF]

, 2019
Phytohormones regulate the mutualistic symbiotic interaction between legumes and rhizobia, nitrogen-fixing soil bacteria, notably by controlling the formation of the infection thread in the root hair (RH).
Libault, Marc, Qiao, Zhenzhen, Zogli, Prince   +2 more
core   +1 more source

A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming

Molecular Nutrition &Food Research, EarlyView.
Metabolic syndrome (MetS)‐related conditions are key factors in liver damage. A Mediterranean lifestyle shows promise in managing MetS, though its mechanisms remain unclear. This study tested a lab‐designed food mix mimicking the 1960s Mediterranean Diet (MD) on obese and diabetic mice; it prevented hyperlipidemia and reduced oxidative liver damage ...
Giovanna Mercurio, Antonia Giacco, Antonio Dario Troise, Moira Ledbetter, Sabrina De Pascale, Nicla Scopigno, Michela Vigliotti, Matteo Mazzola, Giuseppe Riccio, Andrea Scaloni, Maria Moreno, Alberto Fiore, Federica Cioffi, Elena Silvestri   +13 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Discrimination of Tryptophan Enantiomers at Sub‐pm Level by Multiparametric Analysis of a Label‐Free Organic Immunosensor

Small Methods, EarlyView.
Multiparametric analysis is a crucial aspect for enhancing the final sensitivity of biosensors based on organic transistors. The traditional approaches to treat the experimental data are not always suitable to extract the correct response. In this work EGOT characteristics are processed to achieve enantiodiscrimination of free Tryptophan enantiomers ...
Matteo Genitoni, Pierpaolo Greco, Alessandro Paradisi, Matteo Sensi, Marcello Berto, Mauro Murgia, Michele Di Lauro, Carlo Augusto Bortolotti, Luciano Fadiga, Fabio Biscarini   +9 more
wiley   +1 more source