Results 121 to 130 of about 55,792 (321)
Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]
, 2005 Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Baran, H +5 more
core
Molecular Psychiatry, 2019 The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is increased in the brains of people with schizophrenia. We tested the extent to which: (1)
J. Kindler +12 more
semanticscholar +1 more source
iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
BMC Veterinary ResearchBackground This study aimed to identify the roles of L-tryptophan (Trp) and its rate-limiting enzymes on the receptivity of bovine endometrial epithelial cells. Real-time PCR was conducted to analyze the differential expression of genes between different
Peng-Chao Wang +8 more
doaj +1 more source
Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]
, 2014 Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona +6 more
core +3 more sources
Interdisciplinary Medicine, EarlyView.This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang +4 more
wiley +1 more source
Kynurenine pathway metabolites in migraine [PDF]
The Journal of Headache and Pain, 2015 Kynurenine pathway (KP), the quantitatively main branch of tryptophan metabolism, has long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to activate glutamate receptors, thus potentially influencing a large group of functions in the central ...
openaire +3 more sources
International Journal of Molecular Sciences, 2020 Neurodegenerative diseases are multifactorial, initiated by a series of the causative complex which develops into a certain clinical picture. The pathogenesis and disease course vary from patient to patient.
N. Török, Masaru Tanaka, L. Vécsei
semanticscholar +1 more source
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
core +1 more source