Results 121 to 130 of about 48,449 (279)

Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review

The Chemical Record, EarlyView.
Indole and its derivatives represent a vital class of heterocycles with broad applications in pharmaceuticals, agrochemicals, and materials science. This review explores their applications, biosynthesis, key derivatives such as tryptophan, and presents an overview of both classical and modern synthetic methodologies, with a focus on sustainable ...
Raphael Silva Moratório de Moraes, Ana Beatriz Mestre Botelho, Gabriel Tavares de Almeida Pinto, Searitha Couto Rodrigues, Maria Tereza Miranda Martins, Deivid Lucas Alves Soares, Camille Cardoso Cruz, Aline de Almeida Pinto, Flaviana Rodrigues Fintelman Dias, Patricia Dias Fernandes, Anna Claudia Cunha   +10 more
wiley   +1 more source

The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study

Frontiers in Psychiatry
Depressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská, Marcela Morvová, Zuzana Paduchová, Jana Muchová, Iveta Garaiova, Zdenka Ďuračková, Libuša Šikurová, Jana Trebatická   +7 more
doaj   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, EarlyView.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

Characteristic Features of Kynurenine Aminotransferase Allosterically Regulated by (Alpha)-Ketoglutarate in Cooperation with Kynurenine

PLoS ONE, 2012
Kynurenine aminotransferase from Pyrococcus horikoshii OT3 (PhKAT), which is a homodimeric protein, catalyzes the conversion of kynurenine (KYN) to kynurenic acid (KYNA). We analyzed the transaminase reaction mechanisms of this protein with pyridoxal-5'-phosphate (PLP), KYN and α-ketoglutaric acid (2OG) or oxaloacetic acid (OXA).
Kazufumi Takano, Ken Okada, Yuichi Koga, Clement Angkawidjaja, Shigenori Kanaya   +4 more
openaire   +4 more sources

Quantitative Determination of Tryptophan Metabolites (via Kynurenine) in Biologic Fluids [PDF]

, 1959
Dino Coppini, Carlo Benassi, Marco Montorsi   +2 more
openalex   +1 more source

Microbial and Metabolic Disorders in Cervical Cancer: Structural Insights, Biomarkers, Mechanisms, and Therapeutic Strategies

Cancer Science, EarlyView.
We unravel synergistic mechanisms by which microbial‐host metabolic networks regulate the tumor immune microenvironment and therapy resistance, bridging gaps between microbiota research and cancer metabolism. Identified biomarkers (e.g., Lactobacillus, C8‐ceramide‐1‐phosphate) and therapeutic approaches (e.g., FMT combined with immune checkpoint ...
Hong Tao, Luyu Wang, Yi Ding, Lixian Yi, Mutian Han, Mengmeng Gu, Jian Wu   +6 more
wiley   +1 more source

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source

Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases

Respiratory Research
Background Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development.
Yuchen Sun, Kosuke Saito, Atsuhito Ushiki, Mitsuhiro Abe, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Kenji Tsushima, Kazuhisa Takemoto, Rika Ishikawa, Toshiko Momiyama, Shin-ichiro Matsuyama, Noriaki Arakawa, Hirotoshi Akane, Takeshi Toyoda, Kumiko Ogawa, Motonobu Sato, Kazuhiko Takamatsu, Kazuhiko Mori, Takayoshi Nishiya, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Masayuki Hanaoka   +26 more
doaj   +1 more source

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

ForePass outperforms Semaglutide in weight control, glucose metabolism, and gut microbiota in swine

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims This study evaluated the metabolic efficacy of ForePass—a novel, incision‐free, reversible, endoscopically delivered device that mimics biliopancreatic diversion—in growing pigs. The primary aim was the superiority of ForePass over Semaglutide in improving insulin sensitivity (SI).
Sara Russo, Luca Proto, Manoel Galvao Neto, Giulia Angelini, Samantha Pezzica, Fabrizia Carli, Elena Previti, Maria Emiliana Caristo, Vincenzo Bove, Rima Chakaroun, Sara Roggiani, Valentina Tremaroli, Carel W. Le Roux, Stefan R. Bornstein, Amalia Gastaldelli, Ivo Boskoski, Geltrude Mingrone   +16 more
wiley   +1 more source