Results 121 to 130 of about 40,027 (305)

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

Genes & Development, 2019
In this study, Venkateswaran et al. investigated how the proto-oncogene MYC regulates the metabolism of amino acids other than glutamine in cancer.
Niranjan Venkateswaran, M. Lafita-Navarro, Yi‐Heng Hao, Jessica A. Kilgore, Lizbeth Perez-Castro, Jonathan Braverman, N. Borenstein-Auerbach, Min Kim, Nicholas P. Lesner, Prashant Mishra, T. Brabletz, J. Shay, R. Deberardinis, R. Deberardinis, N. Williams, Ömer H. Yilmaz, Ömer H. Yilmaz, Maralice Conacci‐Sorrell   +17 more
semanticscholar   +1 more source

Discrimination of Tryptophan Enantiomers at Sub‐pm Level by Multiparametric Analysis of a Label‐Free Organic Immunosensor

Small Methods, EarlyView.
Multiparametric analysis is a crucial aspect for enhancing the final sensitivity of biosensors based on organic transistors. The traditional approaches to treat the experimental data are not always suitable to extract the correct response. In this work EGOT characteristics are processed to achieve enantiodiscrimination of free Tryptophan enantiomers ...
Matteo Genitoni, Pierpaolo Greco, Alessandro Paradisi, Matteo Sensi, Marcello Berto, Mauro Murgia, Michele Di Lauro, Carlo Augusto Bortolotti, Luciano Fadiga, Fabio Biscarini   +9 more
wiley   +1 more source

The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal

International Journal of Tryptophan Research, 2019
The plasma kynurenine to tryptophan ([Kyn]/[Trp]) ratio is frequently used to express or reflect the activity of the extrahepatic Trp-degrading enzyme indoleamine 2,3-dioxygenase (IDO).
A. Badawy, G. Guillemin
semanticscholar   +1 more source

Kynurenine pathway and human systems

Experimental Gerontology, 2020
The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis. The major route of Trp degradation, the kynurenine pathway (KP), produces a range of biologically active metabolites that can impact or be impacted by a variety of body systems, including the endocrine ...
openaire   +2 more sources

Exploring the impact of microbial dysbiosis on ovarian cancer and the therapeutic potential of probiotics

VIEW, EarlyView.
Ovarian cancer has been linked to the microbiome as a potential environmental contributor, but how this association relates to tumor progression remains unclear. By comparing tumor and nontumor tissues, we identified a severity‐associated microbial and metabolic signature and showed that probiotics can partially restore immune balance and slow tumor ...
Chanyuan Li, Nalan Tu, Xin Ning, Yunyan Cong, Fei Wu, Xiuli Zhang, Runrong Li, Yue Xu, Binqiao Wang, Liqin Jin, Yuanming Shen, Jihong Liu   +11 more
wiley   +1 more source

Pathogenesis of Vitiligo: Integrating Immune and Non‐Immune Cell Crosstalk

The Journal of Dermatology, EarlyView.
ABSTRACT Vitiligo is an acquired autoimmune disease characterized by depigmented macules resulting from melanocyte loss. It is a complex multifactorial disorder in which genetic predisposition is combined with environmental factors; however, its detailed etiology remains unclear.
Shintaro Inoue
wiley   +1 more source

Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study [PDF]

, 2022
Lucette A. Cysique, David Jakabek, Sophia G. Bracken, Yasmin Allen‐Davidian, Benjamin Heng, Sharron Chow, Mona Dehhaghi, Ananda Staats Pires, D.R. Darley, Anthony Byrne, Chansavath Phetsouphanh, Anthony D. Kelleher, Gregory J. Dore, Gail Matthews, Gilles J. Guillemin, Bruce J. Brew   +15 more
openalex   +1 more source

Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation

Allergy, EarlyView.
Integrating skin barrier measurements with omics and machine learning, we found that postbiotics and NAM regulate skin homeostasis through distinct, strain‐ and dose‐dependent mechanisms. Postbiotics primarily modulate skin barrier function by promoting keratinocyte differentiation and suppressing inflammation.
Yagiz Pat, Duygu Yazici, Huseyn Babayev, Sena Ardicli, Xiangting Bu, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Patrick Westermann, Asuncion Garcia‐Sanchez, Manru Li, Ozge Ardicli, Can Zeyneloglu, Marco Pane, Angela Amoruso, Christoph Messner, Ismail Ogulur, Yasutaka Mitamura, Mubeccel Akdis, Cezmi A. Akdis   +21 more
wiley   +1 more source

Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases

Respiratory Research
Background Drug-induced interstitial lung disease (DILD) is a lung injury caused by various types of drugs and is a serious problem in both clinical practice and drug development.
Yuchen Sun, Kosuke Saito, Atsuhito Ushiki, Mitsuhiro Abe, Yoshinobu Saito, Takeru Kashiwada, Yasushi Horimasu, Akihiko Gemma, Koichiro Tatsumi, Noboru Hattori, Kenji Tsushima, Kazuhisa Takemoto, Rika Ishikawa, Toshiko Momiyama, Shin-ichiro Matsuyama, Noriaki Arakawa, Hirotoshi Akane, Takeshi Toyoda, Kumiko Ogawa, Motonobu Sato, Kazuhiko Takamatsu, Kazuhiko Mori, Takayoshi Nishiya, Takashi Izumi, Yasuo Ohno, Yoshiro Saito, Masayuki Hanaoka   +26 more
doaj   +1 more source

Kynurenine monooxygenase BcKMOL: a key regulator of growth, pathogenicity, and disease control in Botrytis cinerea

Frontiers in Microbiology
Kynurenine monooxygenase, a vital rate-limiting enzyme in the kynurenine pathway metabolic branch, has shown promise as a drug target for treating human neurodegenerative diseases.
Bai Li, Bai Li, Xiaoying Liu, Jinping Zang, Hongzhe Cao, Helong Si, Kang Zhang, Kang Zhang, Jihong Xing, Jihong Xing, Jingao Dong, Jingao Dong   +11 more
doaj   +1 more source