Results 131 to 140 of about 55,792 (321)
Obesity, EarlyView.Abstract Objective Fat taste sensitivity has been implicated in long‐term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients. Methods Obesity‐induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform ...
Arnaud Bernard +5 more
wiley +1 more source
Kynurenine pathway metabolites and suicidality
Neuropharmacology, 2017 Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood.
Lena Brundin, Elena Y. Bryleva
openaire +3 more sources
Small, EarlyView.Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti +5 more
wiley +1 more source
Exercise and the microbiota [PDF]
, 2015 The authors are supported in part by research grants from Science Foundation Ireland including a centre grant (Alimentary Pharmabiotic Centre; Grant Numbers SFI/12/RC/2273 and 12/RC/2273). Dr. Orla O’Sullivan is funded by a Starting Investigator Research
Clarke, Siobhan F. +6 more
core +1 more source
Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
TIPS - Trends in Pharmacological Sciences, 2023 T. Stone, Richard O. Williams
semanticscholar +1 more source
Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease
United European Gastroenterology Journal, EarlyView.ABSTRACT Intestinal stricture remains one of the most challenging complications in Crohn's disease, and its underlying mechanisms are poorly understood. Accumulating evidence suggests that gut microbiota is significantly altered in stenotic intestines and may play a key role in the development of fibrogenesis in Crohn's disease.
Caiguang Liu +14 more
wiley +1 more source
Kynurenine metabolism in health and disease
Amino Acids, 2010 Kynurenine is a small molecule derived from tryptophan when this amino acid is metabolised via the kynurenine pathway. The biological activity of kynurenine and its metabolites (kynurenines) is well recognised. Therefore, understanding the regulation of the subsequent biochemical reactions is essential for the design of therapeutic strategies which aim
Kolodziej, L, Paleolog, E, Williams, R
openaire +4 more sources
International Journal of Tryptophan Research, 2019 The kynurenine pathway is important in cellular energy generation and limiting cellular ageing as it degrades about 90% of dietary tryptophan into the essential co-factor NAD+ (nicotinamide adenine dinucleotide).
M. Dehhaghi +2 more
semanticscholar +1 more source
United European Gastroenterology Journal, EarlyView.ABSTRACT Crohn's disease (CD), a type of inflammatory bowel disease (IBD), is a chronic disorder involving any part of the gastrointestinal tract. Ileocecal resection may serve as a more effective treatment option for early CD. However, the potential relationship and mechanisms between the ileocecum and remission induction of CD are still elusive.
Kai Xia +15 more
wiley +1 more source