Results 141 to 150 of about 55,792 (321)

Xanthurenic acid and its rôle in the trytophane metabolism of pyroxidine-deficient rats [PDF]

, 1943
In a previous publication (1) the isolation of a green pigment from the urine of pyridoxine-deficient rats was described. The green pigment was shown to be the product of a reaction between ferric ammonium sulfate or other ferric salts and a compound ...
Haagen-Smit, A. J., Lepkovsky, Samuel, Roboz, Elizabeth   +2 more
core  

Harmonizing NAD+ metabolism with CeMOF nanozyme to orchestrate intraocular pressure modulation for glaucoma treatment

VIEW, EarlyView.
Our findings demonstrate that NAD+ metabolism dysregulation contributes to elevated intraocular pressure in glaucoma. Supplementation with NAD+ precursors reduces IOP by alleviating oxidative stress, cellular senescence, and extracellular matrix deposition.
Youjia Zhang, Ming Chen, Yi Tian, Bo Qin, Xiaoxiao Chen, Yiwen Zhou, Jinhai Huang, Mei Yang, Xinghuai Sun, Yuan Lei, Yuhong Chen   +10 more
wiley   +1 more source

Metabolite changes in blood predict the onset of tuberculosis

, 2018
Immunogenetics and cellular immunology of bacterial infectious ...
Boom, W.H., Dockrell, H.M., Duffy, F.J., GC6-74 Consortium, Hanekom, W.A., Howe, R., Kaufmann, S.H.E., Maertzdorf, J., Mayanja-Kizza, H., McEwen, G., Mohney, R.P., Ottenhoff, T.H.M., Parida, S.K., Scriba, T.J., Suliman, S., Sutherland, J.S., Thiel, B., Thompson, E., Walzl, G., Weiner, J., Zak, D.E., Zyla, J.   +21 more
core   +1 more source

L‐Tryptophan Produced by Bifidobacterium pseudocatenulatum NCU‐08 Delays Aging in SAMP8 Mice by Activating the Sirt1/P53/P21/Rb Signaling Pathway

Aging Cell, EarlyView.
Bifidobacterium pseudocatenulatum NCU‐08, isolated from the feces of centenarians, facilitated the entry of L‐tryptophan into hippocampal neurons of SAMP8 mice, where it was metabolized into NAD+. The increased NAD+ levels activated Sirt1 protein, thereby suppressing the expression of senescence‐associated proteins P53, P21, and Rb, ultimately delaying
Tangchang Xu, Xiaoyun Wu, Yifei Zhang, Yujie Cai, Xinfeng Zhang, Qingwei Zeng, Jie Luo, Jing Wei, Tingtao Chen   +8 more
wiley   +1 more source

Identification of biomarkers of colitis to monitor effects of dietary omega-3 polyunsaturated fatty acids in the interleukin-10 gene-deficient mouse model of inflammatory bowel diseases : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Manawatū, New Zealand [PDF]

, 2016
Inflammatory bowel diseases (IBD) are characterised by chronic inflammation of the gastrointestinal tract including the colon (colitis). Increased dietary intake of salmon, which is rich in eicosapentaenoic acid (EPA), was well tolerated by IBD patients,
Berger, Nadja
core  

MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer

Genes & Development, 2019
In this study, Venkateswaran et al. investigated how the proto-oncogene MYC regulates the metabolism of amino acids other than glutamine in cancer.
Niranjan Venkateswaran, M. Lafita-Navarro, Yi‐Heng Hao, Jessica A. Kilgore, Lizbeth Perez-Castro, Jonathan Braverman, N. Borenstein-Auerbach, Min Kim, Nicholas P. Lesner, Prashant Mishra, T. Brabletz, J. Shay, R. Deberardinis, R. Deberardinis, N. Williams, Ömer H. Yilmaz, Ömer H. Yilmaz, Maralice Conacci-Sorrell   +17 more
semanticscholar   +1 more source

The kynurenine and serotonin pathway, neopterin and biopterin in depressed children and adolescents: an impact of omega-3 fatty acids, and association with markers related to depressive disorder. A randomized, blinded, prospective study

Frontiers in Psychiatry
Depressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská, Marcela Morvová, Zuzana Paduchová, Jana Muchová, Iveta Garaiova, Zdenka Ďuračková, Libuša Šikurová, Jana Trebatická   +7 more
doaj   +1 more source

Reimagining IDO Pathway Inhibition in Cancer Immunotherapy via Downstream Focus on the Tryptophan–Kynurenine–Aryl Hydrocarbon Axis

Clinical Cancer Research, 2018
Significant progress has been made in cancer immunotherapy with checkpoint inhibitors targeting programmed cell death protein 1 (PD-1)–programmed death-ligand 1 signaling pathways.
Brian W. Labadie, R. Bao, J. Luke
semanticscholar   +1 more source

Multi‐Omics Reveal the Metabolic Changes in Cumulus Cells During Aging

Cell Proliferation, EarlyView.
Fatty acid β‐oxidation was elevated in cumulus cells from older mice. Tryptophan metabolism in aged cumulus cells was active. Supplementing with 5‐HT could mitigate aging damage in oocytes. ABSTRACT Maternal age has been reported to impair oocyte quality.
Liangyue Shi, Hengjie Wang, Shuai Zhu, Minjian Chen, Xuejiang Guo, Qiang Wang, Ling Gu   +6 more
wiley   +1 more source

Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity

European Pharmaceutical Journal, 2016
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Slovák L., Poništ S., Kuncírová V., Mihalová D., Fedorova T., Bauerová K.   +5 more
doaj   +1 more source