Results 161 to 170 of about 55,792 (321)

Compositional and Metabolomic Shifts of the Gut Microbiome in Alcohol‐Related Liver Disease

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Alcohol‐related liver disease (ALD) is a major global health concern characterized by steatosis and liver inflammation due to chronic alcohol consumption. Emerging evidence suggests that ALD is not solely a liver pathology but also involves dysfunction of the gut‐liver axis, where alterations in the gut microbiota play a significant role ...
Cheng‐Hao Kuo, Emad El‐Omar, Cheng‐Yen Kao, Jaw‐Town Lin, Chun‐Ying Wu   +4 more
wiley   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, EarlyView.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Urinary kynurenine,tryptophan, and neopterin concentrations during physiological pregnancy

Scientific Reports
During pregnancy the alterations of kynurenine and tryptophan metabolism play an important role in local signalling and the prevention of fetal rejection.
Lenka Kujovská Krčmová, Kateřina Matoušová, Lenka Javorská, Kristýna Mrštná, Nikola Přívratská, Chaweewan Suwanvecho, Dorota Turoňová, Mohamed Farrag, Marian Kacerovský, Bohuslav Melichar   +9 more
doaj   +1 more source

Neuroimmune pathophysiology of long COVID

Psychiatry and Clinical Neurosciences, EarlyView.
Although COVID‐19 was originally considered a respiratory illness, it is now well established that SARS‐CoV‐2 infection can have far‐reaching impacts on the nervous system. Neurological symptoms such as chemosensory dysfunction are frequently observed during acute infection and approximately 10% of COVID‐19 cases will go on to develop new or persistent
Janna K. Moen, Christopher A. Baker, Akiko Iwasaki   +2 more
wiley   +1 more source

The use of isotopic carbon in a study of the metabolism of anthanilic acid in Neurospora [PDF]

, 1949
The finding by Tatum, Banner, and Beadle (l), that the tryptophanless Neurospora mutant strain 10575 accumulates anthranilic acid, which in turn can be utilized for growth of strain 40008, has provided evidence that anthranilic acid is a biochemical ...
Langham, Wright H., Leifer, Edgar, Mitchell, Herschel K., Nyc, Joseph F.   +3 more
core  

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.

Molecules and Cells, 2022
Alessandra Fiore, Leonie Zeitler, Marion Russier, A. Gross, Maria-Kathrin Hiller, J. L. Parker, Luca Stier, T. Köcher, S. Newstead, P. Murray   +9 more
semanticscholar   +1 more source

Exhaustive exercise abolishes REV‐ERB‐α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Acute exhaustive exercise (EE) reduces REV‐ERB‐α protein levels in skeletal muscle, which impairs its transcriptional repression of kynurenine (KYN) 3‐monooxygenase (KMO), a key enzyme in the KYN pathway that converts KYN into potentially neurotoxic metabolites, collectively referred to as ‘kynurenines’. This study identifies KMO
Alisson Luiz da Rocha, Ana Paula Pinto, Ivo Vieira de Sousa Neto, Vitor Rosetto Muñoz, Bruno Brieda Marafon, Lilian Eslaine Costa Mendes da Silva, José Rodrigo Pauli, Dennys Esper Cintra, Eduardo Rochete Ropelle, Fernando Moreira Simabuco, Leandro Pereira de Moura, Ellen Cristini de Freitas, Donato Americo Rivas, Adelino Sanchez Ramos da Silva   +13 more
wiley   +1 more source

Urinary Metabolic Biomarkers of Attentional Control in Children With Attention‐Deficit/Hyperactivity Disorder: A Dimensional Approach Through 1H NMR‐Based Metabolomics

NMR in Biomedicine, Volume 38, Issue 8, August 2025.
This study identified five attentional control subgroups in school‐aged children, with and without ADHD, using VR‐based behavioral tests. NMR metabolomics revealed subgroup‐specific urinary metabolic profiles linked to energy and amino acid metabolism.
Ana del Mar Salmerón, Pilar Fernández‐Martín, Rocío Rodríguez‐Herrera, Francisco Manuel Arrabal‐Campos, Ana Cristina Abreu, Ignacio Fernández, Pilar Flores   +6 more
wiley   +1 more source

Kynurenine pathway and human systems

Experimental Gerontology, 2020
The essential amino acid L-tryptophan (Trp) appears to play an important role in aging by acting as a general regulator of protein homeostasis. The major route of Trp degradation, the kynurenine pathway (KP), produces a range of biologically active metabolites that can impact or be impacted by a variety of body systems, including the endocrine ...
openaire   +3 more sources

INTRACELLULAR LOCALIZATION OF KYNURENINE IN THE FATBODY OF DROSOPHILA [PDF]

, 1961
M. T. M. Rizki
openalex   +1 more source