Results 161 to 170 of about 40,027 (305)

Immunostimulatory and Immunodynamic Modeling Analysis to Determine a Plausible Starting Dose of mRNA‐4359 for Use in First‐In‐Human Trials

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT The investigational antigen‐specific immunotherapy mRNA‐4359 is a lipid nanoparticle–encapsulated mRNA‐based immunotherapy that encodes for the immunogenic indoleamine 2,3‐dioxygenase (IDO) and programmed death‐ligand 1 (PD‐L1) antigens.
Stephen A. Greene, Madhav Channavazzala, Bhairav Paleja, Harshbir Singh Sandhu, Rukmini Kumar, Husain Attarwala, Linh Van, Min Liang   +7 more
wiley   +1 more source

Exploring the Neurobiological Roots of Emotional Behavior in Tryptophan Metabolism: Insights from Novel Kynurenine Aminotransferase Knockout Mice

, 2023
Ágnes Szabó, Eleonóra Spekker, Mónika Szűcs, Keiko Takeda, Kinuyo Ozaki, Hiromi Inoue, Sayo Yamamoto, József Toldi, Etsuro Ono, László Vécsei, Masaru Tanaka   +10 more
openalex   +2 more sources

Association Between Metabolic Syndrome, Obesity, and Cognitive Performances in Individuals With Bipolar Disorders: Cross‐Sectional and Longitudinal Analyses in the FACE‐BD Cohort

Acta Psychiatrica Scandinavica, Volume 153, Issue 2, Page 108-121, February 2026.
ABSTRACT Introduction Metabolic syndrome (MetS) has been suggested to be associated with cognitive impairments in bipolar disorder (BD); however, studies are limited by small sample sizes or cross‐sectional design. Our objective is to evaluate the cross‐sectional and longitudinal associations between MetS and cognitive performances in a large cohort of
I. Palimaru, B. Etain, M. Leboyer, Y. Dansou, P. Favre, S. Gard, V. Aubin, F. Bellivier, R. Belzeaux, P. Courtet, C. Dubertret, E. Haffen, A. Lefrere, P. M. Llorca, E. Olié, M. Polosan, L. Samalin, R. Schwan, the FondaMental Academic Centers of Expertise in Bipolar Disorders (FACE‐BD) Collaborators, B. Etain, E. Olié, M. Leboyer, E. Haffen, P. M. Llorca, V. Barteau, S. Bensalem, O. Godin, H. Laouamri, K. Souryis, S. Hotier, A. Pelletier, F. Hergeta, J. Petrucci, L. Willaume, F. Bellivier, B. Etain, V. Hennion, E. Marlinge, J. Meheust, A. Richard, M. Carminati, H. Francisque, S. Gard, K. M’Bailara, C. Elkael, F. Hoorelbeke, I. Minois, J. Sportich, N. Da Ros, C. Dubertret, N. Mazer, C. Portalier, C. Scognamiglio, A. Bing, P. Laurent, L. Boukhobza, P. Courtet, S. Denat, B. Deffinis, D. Ducasse, M. Gachet, A. Lengvenyté, F. Molière, L. Nass, E. Olié, G. Tarquini, A. Lefrere, E. Moreau, J. Pastol, F. Groppi, H. Polomeni, J. Bauberg, L. Lescalier, I. Muraccioli, A. Suray, R. Cohen, J. P. Kahn, M. Milazzo, O. Wajsbrot‐Elgrabli, T. Bougerol, A. Pouchon, A. Bertrand, B. Fredembach, A. Suisse, Q. Denoual, M. Polosan, A. M. Galliot, L. Brehon, G. Bonny, L. Durand, V. Feuga, N. Kayser, P. Roux, V. Aubin, I. Cussac, M. A. Dupont, J. Loftus, I. Medecin, C. Dubertret, N. Mazer, P. Laurent, L. Samalin, P. M. Llorca, M. Mennetrier, T. Bonnet, D. Lacelle, M. Vayssié, C. Beal, O. Blanc, P. Roux, O. Godin   +110 more
wiley   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

The Role of Kynurenines Produced by Indolamine-2,3-Dioxygenase 1 in Sepsis [PDF]

, 2022
Simon Lerch, Joerg C. Schefold, Thibaud Spinetti   +2 more
openalex   +1 more source

Peripheral and central kynurenine pathway abnormalities in major depression

Brain, behavior, and immunity, 2022
Elisabeth R Paul, L. Schwieler, S. Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, A. Asratian, Lovisa Holm, A. Yngve, R. Dantzer, M. Heilig, J. P. Hamilton, M. Samuelsson   +12 more
semanticscholar   +1 more source

Transcriptomic, proteomic and biochemical comparison of luminescent and non‐luminescent Keroplatinae larvae (Diptera: Keroplatidae)

Insect Molecular Biology, Volume 35, Issue 1, Page 34-47, February 2026.
Transcriptomic and proteomic comparison of luminescent O. fultoni and non‐luminescent Neoditomyia sp show that the substrate binding fraction (SBF) has a similar abundance of hexamerins and the presence of flavin‐dependent reductases. In addition to the high content of keroplatin, SBF also contains considerable amounts of riboflavin and displays ...
Jaqueline R. Silva, Gabriel F. Pelentir, Danilo T. Amaral, Cassius Stevani, Vadim R. Viviani   +4 more
wiley   +1 more source

Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder [PDF]

, 2023
Veli Yıldırım, Şeref Şimşek, İhsan Çetin, Recep Dokuyucu   +3 more
openalex   +1 more source

A novel mechanism of auxin habituation: upregulation of auxin receptor TRANSPORT INHIBITOR RESPONSE 1 allows cell proliferation independent of external auxin

New Phytologist, Volume 249, Issue 3, Page 1268-1282, February 2026.
Summary Exogenously applied auxins are essential for establishing cell lines in tissue cultures and maintaining their proliferation. Cell lines may develop the ability to proliferate even in media lacking auxin, they may become auxin‐habituated. This study investigated the mechanisms underlying this process.
Pavel Jelínek, Karel Müller, Eliška Kobercová, Adéla Přibylová, Milada Čovanová, Petre I. Dobrev, Roberta Vaculíková, Zuzana Vondráková, Lenka Helusová, Anita Bírošíková, Lukáš Fischer, Jan Petrášek   +11 more
wiley   +1 more source

KYNURENINES IN PATHOGENESIS OF ENDOGENOUS PSYCHIATRIC DISORDERS

, 2013
Yuri Shilov, Bezrukov Mv
openalex   +2 more sources