Results 171 to 180 of about 55,792 (321)

Cortisol, Anxiety, and TNFα Mediate the Relationship Between BMI and Executive Functions

Stress and Health, Volume 41, Issue 4, August 2025.
ABSTRACT Overweight and obesity are associated with poorer executive functions (EF). The underlying mechanisms contributing to this relationship are not yet conclusive, but cortisol, anxiety, and inflammation are likely among the contributing factors. Our objective was to evaluate whether fibrinogen, tumour necrosis factor alpha (TNFα), cortisol, and ...
Anna Prunell‐Castañé, María Ángeles Jurado, Xavier Caldú, María José Sender‐Palacios, Consuelo Sánchez Garre, Paloma Salas Gómez‐Pablos, Maite Garolera   +6 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Structural Basis of Regioselective Bromination of Tricyclic Tryptoline by the Tryptophan Halogenase Thal

ChemBioChem, Volume 26, Issue 13, July 11, 2025.
This study shows that the flavin‐dependent tryptophan halogenase Thal also regioselectively halogenates the tricyclic non‐native substrate tryptoline, a β‐carboline with various pharmacological activities. Interestingly, Thal brominates a different position of the shared pharmacophore indole in tryptoline than it does in tryptophan. A crystal structure
Simon Bork, Caroline Besse, Norbert Sewald, Hartmut H. Niemann   +3 more
wiley   +1 more source

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition. [PDF]

, 2015
For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types.
Battle, Stephanie L, Bielas, Jason H, Blau, C Anthony, Detraux, Damien, Devi, Arikketh, Ericson, Nolan G, Ferreccio, Amy, Fiehn, Oliver, Fischer, Karin A, Gu, Haiwei, Hawkins, R David, Hesson, Jennifer, Hockenbery, David, Margaretha, Lilyana, Margineantu, Daciana, Margolin, Adam A, Mathieu, Julie, Moon, Randall T, Raftery, Daniel, Robitaille, Aaron M, Ruohola-Baker, Hannele, Showalter, Megan, Sperber, Henrik, Valensisi, Cristina, Wang, Yuliang, Ware, Carol B, Xu, Zhuojin   +26 more
core  

Peripheral and central kynurenine pathway abnormalities in major depression

Brain, behavior, and immunity, 2022
Elisabeth R Paul, L. Schwieler, S. Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, A. Asratian, Lovisa Holm, A. Yngve, R. Dantzer, M. Heilig, J. P. Hamilton, M. Samuelsson   +12 more
semanticscholar   +1 more source

Muscle‐Derived Small Extracellular Vesicles Mediate Exercise‐Induced Cognitive Protection in Chronic Cerebral Hypoperfusion

Advanced Science, Volume 12, Issue 27, July 17, 2025.
sEVs have a critical role in orchestrating interorgan crosstalk and mediating exercise‐induced therapeutic effects. Lin et al. demonstrates that sEVs miR‐17/20a‐5p mediates the muscle‐brain crosstalk and emphasizes the central role of mTOR signaling in executing molecular programs that can protect brain health in response to exercise. Abstract Physical
Huawei Lin, Lianhua Yin, Weilin Liu, Rui Li, Tao Jiang, Minguang Yang, Yajun Cao, Sinuo Wang, Yan Yu, Cong Chen, Xiaoqin Guo, Wenju Wang, Huanhuan Liu, Yaling Dai, Jiamin Yan, Yanting Lin, Yanyi Ding, Chendong Ruan, Lei Yang, Tiecheng Wu, Jing Tao, Lidian Chen   +21 more
wiley   +1 more source

Biocatalytic reactions, crystal structures and mechanisms of kynurenine formamidases

Tetrahedron Chem
Kynurenine (Kyn) as a non-proteinogenic amino acid, is prevalent in various bioactive natural products, and plays a pivotal role in metabolism and related diseases.
Changmei Liu, Chengyue Miao, Xiaorui Chen, Yan Zhang, Yijian Rao, Zhenbo Yuan   +5 more
doaj  

First‐in‐human phase 1 study of KHK2455 monotherapy and in combination with mogamulizumab in patients with advanced solid tumors

Cancer, Volume 131, Issue 13, 1 July 2025.
Abstract Background Indoleamine 2,3‐dioxygenase 1 (IDO1) is a heme‐containing enzyme that degrades tryptophan (Trp) to kynurenine (Kyn), which suppresses effector T cells and reduces antitumor activity. KHK2455 is a long‐acting selective IDO1 inhibitor that blocks the heme component of the IDO holoenzyme.
Timothy A. Yap, Olivier Rixe, Capucine Baldini, Ursa Brown‐Glaberman, Sergey Efuni, David S. Hong, Christophe Massard, Jameel Muzaffar, Andreea Varga, Emrullah Yilmaz, Yuta Ikawa, Lisa H. Shiue, Yi Liu, Matthew W. Hruska, Henry Zhao, Akihiro Tokunaga, Solmaz Sahebjam   +16 more
wiley   +1 more source

THE KYNURENINE TRANSAMINASE OF RAT KIDNEY

, 1954
Merle Mason
openalex   +1 more source

Kynurenine Formamidase and Tetrahydrofolic Acid. [PDF]

, 1968
Risto Santti, Juhani T. Soini, Gunilla Carlsson, Olav Smidsrød   +3 more
openalex   +1 more source