Results 171 to 180 of about 40,027 (305)

Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects

, 2017
János Tajti, Délia Szok, Gábor Nagy-Grócz, Bernadett Tuka, Anna Petrovics-Balog, József Toldi, László Vécsei   +6 more
openalex   +1 more source

Kynurenin [PDF]

, 2017
openaire   +2 more sources

Kynurenine Measurement [PDF]

, 2020
openaire   +1 more source

Kynurenine Formamidase

Journal of Biological Chemistry, 1974
Cheryl B. Bailey, Conrad Wagner
openaire   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, Volume 16, Issue 1, Page 52-67, January 2026.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, Volume 13, Issue 5, 27 January 2026.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

The electrophilic metabolite of kynurenine, kynurenine-CKA, requires C151 in Keap1 to derepress Nrf2. [PDF]

Redox Biol
Feng J, Carreño M, Jung H, Dayalan Naidu S, Arroyo-Diaz N, Ang AD, Kulkarni B, Kisielewski D, Suzuki T, Yamamoto M, Hayes JD, Honda T, Wilson L, Leon-Ruiz B, Eggler AL, Vitturi DA, Dinkova-Kostova AT.   +16 more
europepmc   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source

Supplementary Figure 2 from Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

, 2023
Dan J.M. Nguyen, George Theodoropoulos, Yingying Li, Chunjing Wu, Wei Sha, Lynn G. Feun, Théodore J. Lampidis, Niramol Savaraj, Medhi Wangpaichitr   +8 more
openalex   +1 more source

UMI‐77 Ameliorates Lipopolysaccharide‐Induced Sepsis‐Associated Encephalopathy by Modulating the Brain‐Gut Axis

Brain and Behavior, Volume 16, Issue 1, January 2026.
Metabolomics‐based analysis of SAE mice by brain‐gut axis found that metabolic pathway analysis indicates that these differential metabolites are mainly involved in the metabolism of linoleic acid, biosynthesis of phenylalanine, tyrosine, and tryptophan, and phenylalanine metabolism in the brain.
Yu Ke, Cuicui Dong, Chang Liu, Menglu Ni, Yuting Chen, Yurou Zhang, Yingyue Wang, Yubin Xu, Guirong Chen   +8 more
wiley   +1 more source