Results 31 to 40 of about 40,027 (305)

Dietary Kynurenine Pathway Metabolites—Source, Fate, and Chromatographic Determinations

International Journal of Molecular Sciences, 2023
Tryptophan metabolism plays an essential role in human health. In mammals, about 95% of dietary tryptophan is metabolized through the kynurenine pathway, which is associated with the development of several pathologies, including neurodegeneration.
I. Sadok, Katarzyna Jędruchniewicz
semanticscholar   +1 more source

Cluster headache and kynurenines

The Journal of Headache and Pain, 2023
Abstract Background The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutamatergic processes, but ...
Tuka Bernadett, Körtési Tamás, Nánási Nikolett, Tömösi Ferenc, Janáky Tamás, Veréb Dániel, Szok Délia, Tajti János, Vécsei László   +8 more
openaire   +4 more sources

Effects of inflammation on the kynurenine pathway in schizophrenia — a systematic review

Journal of Neuroinflammation, 2020
Background In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia.
Bruno Pedraz-Petrozzi, Osama Elyamany, Christoph Rummel, Christoph Mulert   +3 more
doaj   +1 more source

Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis. [PDF]

PLoS ONE, 2016
BACKGROUND:An increase of plasma kynurenine concentrations, potentially bioactive metabolites of tryptophan, was found in subjects with obesity, resulting from low-grade inflammation of the white adipose tissue.
Marie Favennec, Benjamin Hennart, Marie Verbanck, Marie Pigeyre, Robert Caiazzo, Violeta Raverdy, Hélène Verkindt, Audrey Leloire, Gilles J Guillemin, Loïc Yengo, Delphine Allorge, Philippe Froguel, François Pattou, Odile Poulain-Godefroy   +13 more
doaj   +1 more source

Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis

Journal of Cachexia, Sarcopenia and Muscle, 2023
Inflammatory cytokine interleukin‐6 (IL‐6) plays a pivotal role in skeletal muscle degradation after intra‐abdominal sepsis (IAS), with mechanism remained to be elucidated. Indoleamine 2,3‐dioxygenase 1 (IDO‐1), a key enzyme in converting tryptophan into
Tingbin Xie, T. Lv, Tenghui Zhang, D. Feng, Feng Zhu, Yi Xu, Liang Zhang, L. Gu, Zhen Guo, Chao Ding, J. Gong   +10 more
semanticscholar   +1 more source

Linking major depressive disorder pathogenesis with kynurenine pathway - a literature review

Journal of Education, Health and Sport, 2023
Introduction: Depressive disorders are a significant problem. They lead to suffering, loss of interest and may contribute to suicide attempts. Despite the large number of available medications, 10-35% of patients fail to achieve remission.
Dominik Szawica, Aleksandra Kuźniar, Kamila Fularska, Michał Oleszko, Edward Wąsiewicz   +4 more
doaj   +1 more source

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications

Cells, 2021
Diseases of the central nervous system (CNS) remain a significant health, social and economic problem around the globe. The development of therapeutic strategies for CNS conditions has suffered due to a poor understanding of the underlying pathologies ...
Mustafa N. Mithaiwala, D. Santana-Coelho, Grace A. Porter, J. O'Connor   +3 more
semanticscholar   +1 more source

Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy

Journal of Translational Medicine, 2019
Background Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation.
Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours, Guy Jerusalem   +5 more
doaj   +1 more source

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

Pharmaceuticals, 2023
Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with a substantial percentage of patients displaying a mixed disease ...
Annelies Heylen, Yannick Vermeiren, Ido P. Kema, Martijn van Faassen, Claude van der Ley, Debby Van Dam, Peter P. De Deyn   +6 more
doaj   +1 more source

Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

International Journal of Tryptophan Research, 2017
Regulatory and functional aspects of the kynurenine (K) pathway (KP) of tryptophan (Trp) degradation are reviewed. The KP accounts for ~95% of dietary Trp degradation, of which 90% is attributed to the hepatic KP.
A. Badawy
semanticscholar   +1 more source