Results 31 to 40 of about 55,792 (321)

Antibiotic-Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa. [PDF]

Immunology
Antibiotic‐induced dysbiosis of the gut microbiota shifts host tryptophan metabolism and impairs the innate immune response during Pseudomonas aeruginosa pulmonary infection. (A) Eubiosis: During eubiosis, the intestinal microbiota metabolises tryptophan into indole metabolites, which keeps tryptophan levels within normal serum concentrations. However,
de Brito CB, do Nascimento Arifa RD, de Oliveira Bezerra R, Dias Igídio CE, de Amorim-Santos BM, de Menezes Santos ACP, Barbosa LM, Barbosa JPP, Cassiano LMG, Kohlhoff M, Fagundes M, Batista RRÁ, Queiroz-Junior CM, Saliba AM, Raposo JDA, Braga FC, Coimbra RS, Teixeira MM, Fagundes CT, Souza DG.   +19 more
europepmc   +2 more sources

Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial

Journal of Neuroinflammation, 2021
Background Administration of lipopolysaccharide (LPS) from Gram-negative bacteria, also known as the human endotoxemia model, is a standardized and safe model of human inflammation. Experimental studies have revealed that peripheral administration of LPS
Vincent Millischer, Matthias Heinzl, Anthi Faka, Michael Resl, Ada Trepci, Carmen Klammer, Margot Egger, Benjamin Dieplinger, Martin Clodi, Lilly Schwieler   +9 more
doaj   +1 more source

Fathoming the kynurenine pathway in migraine: why understanding the enzymatic cascades is still critically important [PDF]

, 2015
Kynurenine pathway, the quantitatively main branch of tryptophan metabolism, has been long been considered a source of nicotinamide adenine dinucleotide, although several of its products, the so-called kynurenines, are endowed with the capacity to ...
CURTO, MARTINA, FAZIO, FRANCESCO, Lionetto, L, MARTELLETTI, Paolo, Mitsikostas, Dd   +4 more
core   +1 more source

Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism [PDF]

Molecules, 2020
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive and social functions, progressing severely enough to interfere with daily life. Alzheimer’s disease (AD) accounts for most of the dementia cases. Pathological and clinical findings have led to proposing several hypotheses of AD pathogenesis, finding a presence of
Masaru Tanaka, Zsuzsanna Bohár, László Vécsei   +2 more
openaire   +5 more sources

A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases

Frontiers in Immunology, 2023
There is an increasing interest in the pathophysiological role of the kynurenine pathway of tryptophan metabolism in the regulation of immune function and inflammation.
Arduino A. Mangoni, Arduino A. Mangoni, Angelo Zinellu   +2 more
doaj   +1 more source

Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine [PDF]

, 2015
Glutamate receptors sensitive to N-methyl-d-aspartate (NMDA) are involved in embryonic brain development but their activity may be modulated by the kynurenine pathway of tryptophan metabolism which includes an agonist (quinolinic acid) and an antagonist (
Darlington, L.G., Forrest, C.M., Khalil, O.S., Mcnair, K., Pisar, M., Stone, T.W.   +5 more
core   +1 more source

Functional Impairments in Learning and Signal Propagation Following Prenatal Kynurenine Treatment in Mice. [PDF]

Eur J Neurosci
ABSTRACT The levels of kynurenic acid (KYNA), a metabolite of the kynurenine pathway (KP) of tryptophan degradation, are elevated in the brain of persons with schizophrenia (SZ) and may be linked to cognitive dysfunctions in the disease. Studies in rats indicate that abnormally high fetal brain KYNA may play a pathophysiologically significant role in ...
Beggiato S, Brown PL, Milosavljevic S, Thomas MAR, Piroli MV, Sathyasaikumar KV, Notarangelo FM, Schwarcz R, Pocivavsek A.   +8 more
europepmc   +2 more sources

The kynurenine pathway and the brain: challenges, controversies and promises [PDF]

, 2017
Research on the neurobiology of the kynurenine pathway has suffered years of relative obscurity because tryptophan degradation, and its involvement in both physiology and major brain diseases, was viewed almost exclusively through the lens of the well ...
Schwarcz, Robert, Stone, Trevor W.
core   +1 more source

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

Nature Communications, 2020
Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2 (IDO/TDO) promotes immunosuppression across different cancer types.
L. F. Campesato, S. Budhu, J. Tchaicha, Chien-Huan Weng, M. Gigoux, Ivan J. Cohen, D. Redmond, L. Mangarin, S. Pourpe, Cailian Liu, R. Zappasodi, D. Zamarin, Jillian D. Cavanaugh, Alfredo C Castro, M. Manfredi, Karen McGovern, T. Merghoub, J. Wolchok   +17 more
semanticscholar   +1 more source

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Journal of Neuroinflammation, 2021
Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools.
Li-ming Chen, Chunhui Bao, Yu Wu, Shiwei Liang, Di Wang, Luyi Wu, Yan Huang, Hui-rong Liu, Huan-gan Wu   +8 more
semanticscholar   +1 more source