Results 61 to 70 of about 48,449 (279)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during chemoradiation in patients with cervical carcinoma

Pteridines, 2021
The aim of this study was to investigate the changes in circulating concentrations of citrulline, neopterin, kynurenine, and tryptophan during the course of chemoradiation in patients with cervical cancer.
Pospíšková Markéta, Strouhal Ondřej, Hlídková Eva, Vlachová Zuzana, Melichar Bohuslav, Doležel Martin   +5 more
doaj   +1 more source

Paliperidone Reversion of Maternal Immune Activation-Induced Changes on Brain Serotonin and Kynurenine Pathways

Frontiers in Pharmacology, 2021
Emerging evidence indicates that early-life exposure to environmental factors may increase the risk for schizophrenia via inflammatory mechanisms. Inflammation can alter the metabolism of tryptophan through the oxidative kynurenine pathway to compounds ...
Karina S. MacDowell, Karina S. MacDowell, Karina S. MacDowell, Eva Munarriz-Cuezva, Eva Munarriz-Cuezva, J. Javier Meana, J. Javier Meana, J. Javier Meana, Juan C. Leza, Juan C. Leza, Juan C. Leza, Jorge E. Ortega, Jorge E. Ortega, Jorge E. Ortega   +13 more
doaj   +1 more source

The Kynurenine Pathway

, 2012
The kynurenine pathway represents a major route for the catabolism of tryptophan (TRP). In the body, TRP is transported around the periphery either bound to albumin (90%) or in free form (10%), the two states existing in equilibrium (McMenamy 1965). However, only free form TRP can be transported across the blood-brain barrier (BBB) by the competitive ...
Gilles J. Guillemin, Yiquan Chen
openaire   +3 more sources

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Age-related increase of kynurenic acid in human cerebrospinal fluid-IgG and beta(2)-microglobulin changes [PDF]

, 2005
Kynurenic acid (KYNA) is an endogenous metabolite in the kynurenine pathway of tryptophan degradation and is an antagonist at the glycine site of the N-methyl-D-aspartate as well as at the alpha 7 nicotinic cholinergic receptors. In the brain tissue KYNA
Baran, H, Ferraz-Leite, H, Kainz, A, Kalina, P, Kepplinger, B, Newcombe, J   +5 more
core  

Differential Phase Contrast Imaging to Predict MSC Immune Function

Advanced Healthcare Materials, EarlyView.
This work employs quantitative differential phase contrast (qDPC) imaging technique to non‐invasively extract morphological features from live Mesenchymal Stromal Cells (MSCs) for single cell prediction on cell immunomodulatory capacity. This work establishes a foundation for scalable, non‐destructive monitoring of MSCs immunomodulatory capacity ...
Kejie Rui, Priyanka Priyadarshani, Adrian Ross Liversage, Carlos Munoz, Steven Stice, Luke J. Mortensen   +5 more
wiley   +1 more source

IFNγ-INDUCED KINURENINE PRODUCTION AND INDOLAMINE 2,3-DIOXYGENASE GENE EXPRESSION IN PSORIASIS

Медицинская иммунология, 2014
. An alternative pathway of L-tryptophan biotransformation is provided by the indolamine 2,3-dioxygenase (INDO), and it results into synthesis of kynurenine and other «distal» metabolites, playing a pivotal role in immunoregulation and down-regulation of
D. A. Kaut, R. S. Yamidanov, S. V. Sadovnikov, O. M. Kapuler, V. A. Vakhitov, S. V. Sibiryak   +5 more
doaj   +1 more source

Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Brain injury and neurological deficit are consequences of cardiac arrest (CA), leading to high morbidity and mortality. Peripheral activation of the kynurenine pathway (KP), the main catabolic route of tryptophan metabolized at first into ...
Jacopo Lucchetti, Francesca Fumagalli, Davide Olivari, Roberta Affatato, Claudia Fracasso, Daria De Giorgio, Carlo Perego, Francesca Motta, Alice Passoni, Lidia Staszewsky, Deborah Novelli, Aurora Magliocca, Silvio Garattini, Roberto Latini, Giuseppe Ristagno, Marco Gobbi   +15 more
doaj   +1 more source

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis [PDF]

, 2009
Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasites <i>Trypanosoma brucei rhodesiense</i> or <i>Trypanosoma brucei gambiense</i>, and is a major cause of systemic and neurological disability ...
Adams, B. Bradley, Clark, Eastman, Eastman, Giles, Gonzalez, Guidetti, Hirumi, J. Rodgers, Jennings, Jennings, Jhamandas, Kamleh, Kennedy, Kennedy, Kennedy, Kennedy, M. P. Barrett, Moffett, Okuda, Okuda, P. G. E. Kennedy, Pepin, Perkins, Pfefferkorn, P  pin, R  z, Sanni, Schroten, Schwarcz, Smith, Sternberg, Stone, Stone, Stone, T. W. Stone, Vincendeau   +37 more
core   +2 more sources