Results 61 to 70 of about 55,792 (321)
Obesity and cancer: existing and new hypotheses for a causal connection [PDF]
, 2018 Existing explanations of obesity-associated cancer emphasise direct mutagenic effects of dietary components or hormonal imbalance. Some of these hypotheses are reviewed briefly, but recent evidence suggests a major role for chronic inflammation in cancer
Darlington, L. Gail +2 more
core +2 more sources
The Footprint of Kynurenine Pathway in Cardiovascular Diseases
International Journal of Tryptophan Research, 2022 Kynurenine pathway is the main route of tryptophan metabolism and produces several metabolites with various biologic properties. It has been uncovered that several cardiovascular diseases are associated with the overactivation of kynurenine pathway and ...
Moein Ala, S. P. Eftekhar
semanticscholar +1 more source
Supersulfide biology and translational medicine for disease control
British Journal of Pharmacology, EarlyView., 2023 Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu +5 more
wiley +1 more source
Kynurenines in CNS disease: regulation by inflammatory cytokines
Frontiers in Neuroscience, 2014 The kynurenine pathway metabolizes the essential amino acid tryptophan and generates a number of neuroactive metabolites collectively called the kynurenines.
Brian M Campbell +3 more
doaj +1 more source
Vagus Nerve Stimulation in Refractory Epilepsy: Effects on Pro- and Anti-Inflammatory Cytokines in Peripheral Blood [PDF]
, 2010 Objective: The vagus nerve has important immunological functions that may be relevant for its anticonvulsive action. We postulate that this anticonvulsive action is activated by a shift in the immune system resulting in a reduction of neurotoxic and an ...
Berfelo, M. W. +6 more
core +2 more sources
Kynurenine Acid - Metabolism And Regulation Of Kynurenine Pathway
Journal of Education, Health and Sport, 2017 Kozłowska Magdalena, Kozłowski Piotr. Kynurenine acid - metabolism and regulation of kynurenine pathway. Journal of Education, Health and Sport. 2017;7(7):888-895. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.891286 http://ojs.ukw.edu.pl/index.php/johs/article/view/4815 The journal has had 7 points in Ministry of Science ...
Piotr Kozłowski, Magdalena Kozlowska
openaire +3 more sources
Journal of Pharmacological Sciences, 2015 Kynurenine is a potential contributor to hypotension in animal and human sepsis. The present study was designed to examine whether the voltage-dependent K+ channels encoded by the KCNQ gene family (Kv7 channels) mediate vasodilator effects of kynurenine ...
Kensuke Sakakibara +8 more
doaj +1 more source
Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]
, 2016 Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran +13 more
core +2 more sources
The Kynurenine Pathway: A Finger in Every Pie
Molecular Psychiatry, 2019 The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially increased during an immune response, the KP is a key regulator of the ...
J. Savitz
semanticscholar +1 more source
Malaria Journal, 2017 Background One-fourth of children with cerebral malaria (CM) retain cognitive sequelae up to 2 years after acute disease. The kynurenine pathway of the brain, forming neuroactive metabolites, e.g.
Dag Holmberg +10 more
doaj +1 more source