European Pharmaceutical Journal, 2016 The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO).
Csanova A., Jezova D.
doaj +1 more source
The Role of Activation of the Tryptophan-Kynurenine Axis in the Pathogenesis of Acute Cerebrovascular Diseases: A Literature Review [PDF]
Ķazaķstannyṇ Klinikalyķ MedicinasyIntroduction: Acute cerebrovascular disorders are a major contributor to adult disability. The underlying processes that contribute to their development include inflammation, excitotoxicity, oxidative stress, and dysregulation of the tryptophan ...
Marina Grigolashvili +5 more
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Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]
, 2014 Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona +6 more
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A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
Xanthurenic acid and its rôle in the trytophane metabolism of pyroxidine-deficient rats [PDF]
, 1943 In a previous publication (1) the isolation of a green pigment from the urine of pyridoxine-deficient rats was described. The green pigment was shown to be the product of a reaction between ferric ammonium sulfate or other ferric salts and a compound ...
Haagen-Smit, A. J. +2 more
core
Exercise and the microbiota [PDF]
, 2015 The authors are supported in part by research grants from Science Foundation Ireland including a centre grant (Alimentary Pharmabiotic Centre; Grant Numbers SFI/12/RC/2273 and 12/RC/2273). Dr. Orla O’Sullivan is funded by a Starting Investigator Research
Clarke, Siobhan F. +6 more
core +1 more source
Translating Metabolic Reprogramming into New Targets for Kidney Cancer. [PDF]
, 2017 In the age of bioinformatics and with the advent of high-powered computation over the past decade or so the landscape of biomedical research has become radically altered.
Abu Aboud, Omran, Weiss, Robert H
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Frontiers in PsychiatryDepressive disorder is a severe mental condition. In addition to genetic factors, immunological-inflammatory factors, oxidative stress, and disturbances in neurotransmitter metabolism, kynurenine and serotonin pathways may play a role.
Lucia Ilavská +7 more
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The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
Frontiers in Neurology, 2017 The primary headache disorders include migraine, which is one of the most frequent neurological disorders, which influences more than 14% of the whole population.
Gábor Nagy-Grócz +12 more
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Dynamic factor analysis for sparse and irregular longitudinal data: an application to metabolite measurements in a COVID-19 study [PDF]
arXivIt is of scientific interest to identify essential biomarkers in biological processes underlying diseases to facilitate precision medicine. Factor analysis (FA) has long been used to address this goal: by assuming latent biological pathways drive the activity of measurable biomarkers, a biomarker is more influential if its absolute factor loading is ...
arxiv