Results 171 to 180 of about 26,944 (259)

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Diurnal and Daily Changes in the Levels of Sesquiterpene Lactone and Other Components in Lettuce Post-Harvest. [PDF]

Molecules
Kamata K, Okada H, Ohta Y.
europepmc   +1 more source

Rosemary metabolite carnosic acid opens Kv1.1 via its voltage sensor and corrects Kv1.1‐linked episodic ataxia in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Episodic ataxia type 1 (EA1) is an autosomal dominant neurological disorder caused primarily by loss‐of‐function mutations in the voltage‐gated potassium channel Kv1.1 (KCNA1). Small molecules that restore Kv1.1 activity hold promise as targeted therapies for EA1, yet current pharmacological strategies remain limited ...
Rían W. Manville, Ryan F. Yoshimura, Hanh A. Nguyen, Ruiming Zhao, Derk J. Hogenkamp, Steve A. N. Goldstein, Geoffrey W. Abbott   +6 more
wiley   +1 more source

Solventless, ambient-pressure production of bio-based lactones over earth-abundant, mixed metal oxide catalysts for circular polyesters. [PDF]

Nat Commun
Kiani D, Rosetto G, Ibrahim F, Bozkurt OD, Pal A, Van Roijen EC, DesVeaux JS, Bare SR, Hermans I, Beckham GT.   +9 more
europepmc   +1 more source

Spray-dried microencapsulation enhances the antioxidant efficacy of <i>Artemisia herba-alba</i> extract in butter: insights from volatile profiling and multivariate analysis. [PDF]

Food Chem X
Lemmadi S, Adoui F, Descours E, Chalut P, Santerre C, Gharsallaoui A.   +5 more
europepmc   +1 more source

A Fly in the Ointment? Non‐Target Fly Pest Benefits From Reduction in Ivermectin During Targeted Selective Treatment

Entomologia Experimentalis et Applicata, EarlyView.
Targeted Selective Treatment (TST) can reduce the rate of resistance development in livestock gastrointestinal nematodes but can also reduce the effects of anthelmintics on non‐target organisms. Most studies of non‐target anthelmintic effects focus on beneficial species.
Megan J. Lewis, Raphael K. Didham, Jacob D. Berson, Theodore A. Evans   +3 more
wiley   +1 more source

Synthesis and characterization of γ-acyloxyl-ε-caprolactones. [PDF]

iScience
Greischar G, Gono Phiri T, Haljun E, Ray J, Ourgessa M, Thesing G, Lofving L, Clarkson A, Bator S, Jno Baptise D, Cole W, Itschner M, Getzler YDYL.   +12 more
europepmc   +1 more source

Sustainable control of cyathostomin infections in practice

Equine Veterinary Education, EarlyView.
Summary Cyathostomins are the most prevalent helminths in horses and are found in nearly all grazing groups. These parasites have been shown to exhibit widespread anthelmintic resistance and can cause clinical disease, so they are a growing concern.
J. B. Matthews, T. S. Mair
wiley   +1 more source

Integrative Phytochemical and Transcriptomic Analysis Reveals Genes Regulating 14-Deoxyandrographolide in Thai <i>Andrographis paniculata</i>. [PDF]

ACS Omega
Thongkan N, Thitikornpong W, Muangprom A, Thongphichai W, Sangarwut N, Chakhonkaen S, Tongmark K, Rattanakitti A, Kaewmungkun K, Chuanasa T, Sukrong S.   +10 more
europepmc   +1 more source

Tapeworm testing: Coprological and antibody‐based approaches across colic types in a German equine hospital population

Equine Veterinary Education, EarlyView.
Summary Background The association between tapeworm infection and equine colic is established, but gaps remain regarding specific colic types. Objectives To assess the relationship between tapeworm test results and equine colic types: The study aimed to determine if ileocaecal disorders (IC) are more frequently associated with Anoplocephala spp ...
K. L. Adamasky, K. Drozdzewska, P. Schmitz, N. Peczak, K. L. Lightbody, J. B. Matthews, M. K. Nielsen, R. Merle, G. von Samson‐Himmelstjerna, H. Gehlen   +9 more
wiley   +1 more source