ABSTRACT Rationale Bioactive (E)‐stilbenoids in vine extracts are prone to light‐induced transformation into the respective (Z)‐isomers and further degradation products, often resulting in a loss of bioactivity. We sought to study stilbenoid degradation beyond that of the well‐researched resveratrol due to the high diversity of stilbenoids in nature ...
Paul Besrukow +3 more
wiley +1 more source
A synthetic metabolic pathway for the de novo biosynthesis of medium chain length γ- and δ-lactones. [PDF]
Muller J, Xia A, Jones P.
europepmc +1 more source
Indirect identification of 4,21-dehydrocorynenantheinaldehyde as an intermediate in the biosynthesis of ajmalicine and related alkaloids [PDF]
Hoyer, G. A. +3 more
core
Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis
Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng +5 more
wiley +1 more source
Diverse and Bioactive Lactones from the Sri Lankan Mangrove-Derived Fungus <i>Talaromyces</i> sp. SCSIO41445. [PDF]
Wijerathna P +10 more
europepmc +1 more source
Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz +3 more
wiley +1 more source
Turning Mushy Lipids into Fruity Notes: Unlocking Lactone Biosynthesis Potential in Fat Industry Lipid Waste. [PDF]
Małajowicz J +3 more
europepmc +1 more source
ABSTRACT Instrumental characterisation of the volatile organic compounds (VOCs), responsible for off‐aroma, is mainly centred on gas chromatography‐based techniques. Despite previous reviews that have addressed the chemical compounds and biosynthetic pathways of off‐aroma generation, to date, there is a lack of a comprehensive review that critically ...
Piyumi Chathurangi Wanniarachchi +3 more
wiley +1 more source
Isolation and In Vitro Activity of Sesquiterpene Lactones from <i>Eremanthus crotonoides</i> as SARS-CoV-2 Protease Inhibitors and Cytotoxic Agents. [PDF]
de Moura PHB +10 more
europepmc +1 more source

