Lactylation-driven gene signatures define breast cancer prognosis: a predictive model and insights into immune microenvironment dynamics. [PDF]
Li C, Hu C, Liu X, Li M.
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Comprehensive analysis of proteomics and lactylation proteomics in ovarian granulosa cells of patients with polycystic ovary syndrome. [PDF]
Liu L +11 more
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Lactate-driven ATP6V1B2 lactylation triggers asthmatic inflammation by linking lysosomal dysfunction to mitochondrial ROS-dependent pyroptosis. [PDF]
Bai Q +10 more
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Histone H4K8 lactylation promotes glioblastoma progression by inducing NUPR1-mediated autophagosome‒lysosome fusion. [PDF]
Zhao J +11 more
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<i>Porphyromonas gingivalis</i> infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells. [PDF]
Wu Q +5 more
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Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer. [PDF]
Chao L, Xu Y, Yang Y, Ao X, Liang J.
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Lactate, histone lactylation and cancer hallmarks
Expert Reviews in Molecular Medicine, 2023Abstract Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel ...
Xinyu Lv, Yingying Lv, Xiaofeng Dai
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