Results 161 to 170 of about 52,713 (325)

Cell cycle-dependent methyl esterification of lamin B.

, 1987
Daniel Chelsky, J.F. Olson, Daniel E. Koshland   +2 more
openalex   +1 more source

Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches

Aging Cell, EarlyView.
Supplementation with the natural senolytic agent fisetin attenuated age‐related declines in physical function in mice. Better physical function with fisetin was accompanied by lower expression of cell senescence‐related genes. Fisetin treatment had comparable effects on physical function as genetic clearance of senescent cells and synthetic senolytic ...
Kevin O. Murray, Sophia A. Mahoney, Katelyn R. Ludwig, Jill H. Miyamoto‐Ditmon, Nicholas S. VanDongen, Nirad Banskota, Allison B. Herman, Douglas R. Seals, Robert T. Mankowski, Matthew J. Rossman, Zachary S. Clayton   +10 more
wiley   +1 more source

The fates of chicken nuclear lamin proteins during mitosis: evidence for a reversible redistribution of lamin B2 between inner nuclear membrane and elements of the endoplasmic reticulum.

, 1988
Reimer Stick, Brigitte Angres, Christian F. Lehner, Erich A. Nigg   +3 more
openalex   +1 more source

Chronic Cellular NAD Depletion Activates a Viral Infection‐Like Interferon Response Through Mitochondrial DNA Leakage

Aging Cell, EarlyView.
Chronic NAD depletion in fibroblasts lowers NAD levels, increases mitochondrial mass, and triggers an interferon‐dependent inflammatory response via mtDNA leakage through VDAC1, activating the cGAS‐STING pathway. This links NAD deficiency to metabolic and inflammatory processes, with implications for diseases associated with NAD decline.
Claudia C. S. Chini, Laura Colman, Eduardo Palmieri, Jessica L. Strange, Sonu Kashyap, Bing Han, Andres Benitez‐Rosendo, Gina L. Ciccio Lopez, Sara Peixoto Rabelo, Shreyartha Mukherjee, Gustavo H. de Souza, John Varga, Ralph G. Meyer, Mirella L. Meyer‐Ficca, Eduardo N. Chini   +14 more
wiley   +1 more source

Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome

Aging Cell, EarlyView.
HGPS patient‐derived cortical organoids exhibit progerin accumulation, nuclear abnormalities, and increased senescence in rosette structures, leading to impaired neuronal differentiation and altered gene expression. ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging and primarily caused by ...
Seeun Jeon, Chul‐Sung Park, Juyoung Hong, Jieun Kim, Yun Jin Lee, Junho K. Hur, Ji Yeoun Lee   +6 more
wiley   +1 more source

Lamin chromatin binding is modulated by interactions of different LAP2α domains with lamins and chromatin

iScience
Summary: Lamins A and C are components of the lamina at the nuclear periphery and associate with heterochromatin. A distinct, relatively mobile pool of lamin A/C in the nuclear interior associates with euchromatic regions and with lamin-associated ...
Daria Filipczak, Anna Souchet, Konstantina Georgiou, Roland Foisner, Nana Naetar   +4 more
doaj  

Additional Members of the Rat Liver Lamin Polypeptide Family

, 1989
Scott H. Kaufmann
openalex   +1 more source

Binding of matrix attachment regions to nuclear lamin is mediated by the rod domain and depends on the lamin polymerization state [PDF]

, 1996
Kun Zhao, Amnon Harel, Nico Stuurman, Dina Guedalia, Yosef Gruenbaum   +4 more
openalex   +1 more source

Age‐Dependent Histone Deacetylase 3 Regulation by βA3/A1‐Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age‐Related Macular Degeneration

Aging Cell, EarlyView.
βA3/A1‐crystallin regulates HDAC3 activity and epigenetic processes in the RPE. (A) The illustration demonstrates that βA3/A1‐crystallin plays a crucial role in maintaining IPMK protein expression, which in turn activates HDAC3. (B) When βA3/A1‐crystallin is absent (Cryba1 KO ), IPMK protein expression decreases, resulting in the deactivation of HDAC3.
Sujan Chatterjee, Sayan Ghosh, Zachary Sin, Vishnu Suresh Babu, Loretta Viera Preval, Emily Davis, Nguyen Tran, Sridhar Bammidi, Pooja Gautam, Stacey Hose, Yuri Sergeev, Miguel Flores‐Bellver, Kevin Ritter, Henning J. Jessen, Issam Al Diri, Debasish Sinha, Prasun Guha   +16 more
wiley   +1 more source

Change of karyoskeleton during spermatogenesis of Xenopus: expression of lamin LIV, a nuclear lamina protein specific for the male germ line.

, 1985
Ricardo Benavente, KrohneG
openalex   +1 more source