Results 1 to 10 of about 1,866,196 (278)

Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases

Frontiers in Pharmacology, 2022
Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng, Qianyu Tang, Fan Xiao, Nian Fu, Nian Fu   +4 more
doaj   +2 more sources

Increased Lamin B1 Levels Promote Cell Migration by Altering Perinuclear Actin Organization

Cells, 2020
Cell migration requires reposition and reshaping of the cell nucleus. The nuclear lamina is highly important for migration of both primary and cancer cells.
Andrea Fracchia, Tal Asraf, Mali Salmon-Divon, Gabi Gerlitz   +3 more
doaj   +2 more sources

Drosophila as a Model for Studying the Roles of Lamins in Normal Tissues and Laminopathies [PDF]

Cells
Nuclear processes are fundamental to the regulation of cellular, tissue, and organismal function, especially in complex multicellular systems. Central to these processes are lamins and lamin-associated proteins, which contribute to nuclear structure ...
Aleksandra Zielińska, Marta Rowińska, Aleksandra Tomczak, Ryszard Rzepecki   +3 more
doaj   +2 more sources

Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy

Cells, 2020
LMNA encodes for Lamin A/C, type V intermediate filaments that polymerize under the inner nuclear membrane to form the nuclear lamina. A small fraction of Lamin A/C, less polymerized, is also found in the nucleoplasm. Lamin A/C functions include roles in
Anne T. Bertrand, Astrid Brull, Feriel Azibani, Louise Benarroch, Khadija Chikhaoui, Colin L. Stewart, Ohad Medalia, Rabah Ben Yaou, Gisèle Bonne   +8 more
doaj   +2 more sources

An evolutionarily conserved role for separase in the regulation of nuclear lamins [PDF]

Cell Death Discovery
Separase is a well-conserved endopeptidase that facilitates sister chromatid separation at the metaphase-anaphase transition by cleaving cohesins. Beyond its role in chromosome segregation, Separase also participates in various biological processes ...
Francesca Cipressa, Gaëlle Pennarun, Giuseppe Bosso, Serena Rosignoli, Liliana Tullo, Nadia Schiralli, Claudia Di Dio, Chiara Borghi, Alessandro Paiardini, Giuseppe Esposito, Michael Lewis Goldberg, Pascale Bertrand, Giovanni Cenci   +12 more
doaj   +2 more sources

Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

BMC Molecular and Cell Biology, 2019
Background Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus as it also interacts with ...
Devika Ranade, Roopali Pradhan, Muhunden Jayakrishnan, Sushmitha Hegde, Kundan Sengupta   +4 more
doaj   +2 more sources

Lamin A/C protects chromatin accessibility during mechanical loading in human skeletal muscle [PDF]

Cell Communication and Signaling
Background Skeletal muscle nuclei (myonuclei) are subjected to high mechanical stress which plays a critical role in muscle tissue integrity and plasticity.
Saline Jabre, Emeline Cherchame, Natalia Pinzón, Eline Lemerle, Marc Bitoun, Catherine Coirault   +5 more
doaj   +2 more sources

Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2

Diabetes, 2021
Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate the function of lamin A/C in adipose tissue, we created mice with an adipocyte-specific loss of Lmna ...
C. Corsa, Carolyn M. Walsh, Devika P. Bagchi, Maria C Foss Freitas, Ziru Li, Julie Hardij, Katrina Granger, H. Mori, Rebecca L. Schill, Kenneth T. Lewis, J. Maung, R. Azaria, A. Rothberg, E. Oral, O. MacDougald   +14 more
semanticscholar   +1 more source

LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

eLife, 2021
Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner   +8 more
doaj   +1 more source

Super-Resolution Imaging of the A- and B-Type Lamin Networks: A Comparative Study of Different Fluorescence Labeling Procedures

International Journal of Molecular Sciences, 2021
A- and B-type lamins are type V intermediate filament proteins. Mutations in the genes encoding these lamins cause rare diseases, collectively called laminopathies.
Merel Stiekema, F. Ramaekers, D. Kapsokalyvas, M. V. van Zandvoort, Rogier J. A. Veltrop, J. Broers   +5 more
semanticscholar   +1 more source