Results 21 to 30 of about 1,866,196 (278)
Viscoelastic behavior of human lamin A proteins in the context of dilated cardiomyopathy. [PDF]
PLoS ONE, 2013 Lamins are intermediate filament proteins of type V constituting a nuclear lamina or filamentous meshwork which lines the nucleoplasmic side of the inner nuclear membrane.
Avinanda Banerjee +6 more
doaj +1 more source
Disruption of spermatogenesis in mice lacking A-type lamins [PDF]
Journal of Cell Science, 2004 Nuclear lamins are structural protein components of the nuclear envelope. Mutations in LMNA, the gene coding for A-type lamins, result in several human hereditary diseases, the laminopathies, which include Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, familial partial lipodystrophy and Hutchinson-Gilford progeria.
Alsheimer, M. +5 more
openaire +3 more sources
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
Open Biology, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Romina Burla +14 more
doaj +1 more source
Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. [PDF]
MHR: Basic science of reproductive medicine, 2015 The nuclear lamina (NL) is a filamentous protein meshwork, composed essentially of lamins, situated between the inner nuclear membrane and the chromatin. There is mounting evidence that the NL plays a role in spermatid differentiation during spermiogenesis.
R. Elkhatib +7 more
semanticscholar +3 more sources
The wide and growing range of lamin B-related diseases: from laminopathies to cancer
Cellular and Molecular Life Sciences, 2022 B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the nucleus.
C. Evangelisti +7 more
semanticscholar +1 more source
PLoS ONE, 2017 The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi +16 more
doaj +1 more source
bioRxiv, 2021 The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms.
A. Vahabikashi +15 more
semanticscholar +1 more source
Proteins that bind A-type lamins: integrating isolated clues [PDF]
Journal of Cell Science, 2004 What do such diverse molecules as DNA, actin, retinoblastoma protein and protein kinase Cα all have in common? They and additional partners bind `A-type' lamins, which form stable filaments in animal cell nuclei. Mutations in A-type lamins cause a bewildering range of tissue-specific diseases, termed `laminopathies', including Emery-Dreifuss muscular ...
Michael S, Zastrow +2 more
openaire +2 more sources
Altered protein dynamics of disease-associated lamin A mutants
BMC Cell Biology, 2004 Background Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes.
Worman Howard J +5 more
doaj +1 more source
Cells, 2021 The essential components of splicing are the splicing factors accumulated in nuclear speckles; thus, we studied how DNA damaging agents and A-type lamin depletion affect the properties of these regions, positive on the SC-35 protein.
Soňa Legartová +5 more
doaj +1 more source