Results 71 to 80 of about 1,866,196 (278)

Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex

IBRO Reports, 2018
Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate ...
Yasuharu Takamori, Yukie Hirahara, Taketoshi Wakabayashi, Tetsuji Mori, Taro Koike, Yosky Kataoka, Yasuhisa Tamura, Shuji Kurebayashi, Kiyoshi Kurokawa, Hisao Yamada   +9 more
doaj   +1 more source

Nuclear mechanoprotection: From tissue atlases as blueprints to distinctive regulation of nuclear lamins

APL Bioengineering, 2022
Two meters of DNA in each of our cells must be protected against many types of damage. Mechanoprotection is increasingly understood to be conferred by the nuclear lamina of intermediate filament proteins, but very different patterns of expression and ...
Mai Wang, Irena Ivanovska, Manasvita Vashisth, Dennis E. Discher   +3 more
doaj   +1 more source

Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

Journal of Cell Biology, 1999
The nuclear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear membrane and represents an important determinant of interphase nuclear architecture. Its major components are the A- and B-type lamins.
Teresa L. Sullivan, D. Escalante-Alcalde, H. Bhatt, M. Anver, N. Bhat, K. Nagashima, C. Stewart, B. Burke   +7 more
semanticscholar   +1 more source

Lamin A/C Mechanotransduction in Laminopathies

Cells, 2020
Mechanotransduction translates forces into biological responses and regulates cell functionalities. It is implicated in several diseases, including laminopathies which are pathologies associated with mutations in lamins and lamin-associated proteins ...
F. Donnaloja, Federica Carnevali, E. Jacchetti, M. Raimondi   +3 more
semanticscholar   +1 more source

Differential Expression of A-Type and B-Type Lamins during Hair Cycling

PLoS ONE, 2009
Multiple genetic disorders caused by mutations that affect the proteins lamin A and C show strong skin phenotypes. These disorders include the premature aging disorders Hutchinson-Gilford progeria syndrome and mandibuloacral dysplasia, as well as restrictive dermopathy.
Mubashir, Hanif, Rosengardten, Ylva, Sagelius, Hanna, Rozell, Bjorn, Eriksson, Maria   +4 more
openaire   +5 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The Cardiovascular Magnetic Resonance Phenotype of Lamin Heart Disease.

JACC Cardiovascular Imaging
BACKGROUND Lamin (LMNA) heart disease is a lethal form of dilated cardiomyopathy (DCM). OBJECTIVES The authors explored its cardiovascular magnetic resonance (CMR) phenotype to discover prognostically useful and subclinical biomarkers.
C. Topriceanu, Mashael Al-Farih, G. Joy, Fiona Chan, Matthew Webber, Denis C. Ilie-Ablachim, H. Shiwani, Mansoon Tamang, C. Banks, Stephen Pettit, S. E. Petersen, Benjamin O’Brien, Alun D. Hughes, William Moody, Richard P. Steeds, P. Puddu, Peter Kellman, Konstantinos Savvatis, Saidi A Mohiddin, James C. Moon, Andrea Barison, Paolo Piras, G. Captur   +22 more
semanticscholar   +1 more source

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations

Circulation Research, 2019
Rationale: Mutations in the LMNA gene, encoding LMNA (lamin A/C), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality and morbidity in laminopathies. Objective: To gain insights into the molecular pathogenesis of
S. Chen, R. Lombardi, Jennifer Karmouch, Ju-Yun Tsai, G. Czernuszewicz, Matthew R. G. Taylor, L. Mestroni, C. Coarfa, Priyatansh Gurha, A. Marian   +9 more
semanticscholar   +1 more source