Results 51 to 60 of about 15,070 (269)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Need for NAD⁺: Focus on Striated Muscle Laminopathies

Cells, 2020
Laminopathies are a heterogeneous group of rare diseases caused by genetic mutations in the LMNA gene, encoding A-type lamins. A-type lamins are nuclear envelope proteins which associate with B-type lamins to form the nuclear lamina, a meshwork ...
Déborah Cardoso, Antoine Muchir
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Sheet lamination

, 2022
The sheet lamination (SHL) is one of the processes in additive technologies. In the past, it has been used extensively to make fast, inexpensive paper prototypes. Then the application expanded to metals, polymers (only thermoplastics), textiles and ceramics, which also required the improvement of procedures, i.e. devices (3D printers).
openaire   +2 more sources

Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. [PDF]

, 2014
Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective ...
Coffinier, Catherine, de Jong, Pieter J, Fong, Loren G, Jung, Hea-Jin, Lee, John M, Nobumori, Chika, Tatar, Angelica, Tu, Yiping, Wu, Daniel, Yoshinaga, Yuko, Young, Stephen G   +10 more
core  

A dual role for A-type lamins in DNA double-strand break repair [PDF]

, 2011
A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression are associated with cancer and mutations are linked to degenerative diseases—laminopathies.
Biehl, Kenneth J, Feng, Zhihui, Gonzalez-Suarez, Ignacio, Gonzalo, Susana, Morgado-Palacin, Lucia, Perkins, Stephanie M, Redwood, Abena B, Roti-Roti, Joseph L, Sage, Julien, Shi, Wei, Stewart, Colin L, Vanderwaal, Robert P, Zhang, Junran   +12 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells [PDF]

, 2013
BACKGROUND: Lamins are structural proteins that are the major determinants of nuclear architecture and play important roles in various nuclear functions including gene regulation and cell differentiation.
Chaturvedi, P., Kumar, S., Kumaran, R. I., Parnaik, V. K., Sehgal, P.   +4 more
core   +10 more sources

The Nuclear Envelope as a Regulator of Immune Cell Function

Frontiers in Immunology, 2022
The traditional view of the nuclear envelope (NE) was that it represented a relatively inert physical barrier within the cell, whose main purpose was to separate the nucleoplasm from the cytoplasm.
Anna Selezneva, Alasdair J. Gibb, Dean Willis   +2 more
doaj   +1 more source

Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. [PDF]

, 1988
A cDNA clone encoding a portion of Drosophila nuclear lamins Dm1 and Dm2 has been identified by screening a lambda-gt11 cDNA expression library using Drosophila lamin-specific monoclonal antibodies.
Bare, JW, Benton, BM, Drees, B, Fisher, PA, Gruenbaum, Y, Landesman, Y, Paddy, MR, Saumweber, H, Sedat, JW, Smith, DE   +9 more
core   +1 more source