Results 51 to 60 of about 27,962 (381)

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

Genome Research, 2016
Lamins are components of the peripheral nuclear lamina and interact with heterochromatic genomic regions, termed lamina-associated domains (LADs).
K. Gesson, Philipp Rescheneder, Michael Skoruppa, A. von Haeseler, T. Dechat, R. Foisner   +5 more
semanticscholar   +1 more source

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.

PLoS ONE, 2017
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi, Diane Frankel, Julien Guinde, Sophie Perrin, Sophie Laroumagne, Andrée Robaglia-Schlupp, Kevin Ostacolo, Karim Harhouri, Rachid Tazi-Mezalek, Joelle Micallef, Hervé Dutau, Pascale Tomasini, Annachiara De Sandre-Giovannoli, Nicolas Lévy, Pierre Cau, Philippe Astoul, Patrice Roll   +16 more
doaj   +1 more source

Characterization of lamin mutation phenotypes in Drosophila and comparison to human laminopathies. [PDF]

PLoS ONE, 2007
Lamins are intermediate filament proteins that make up the nuclear lamina, a matrix underlying the nuclear membrane in all metazoan cells that is important for nuclear form and function.
Andrés Muñoz-Alarcón, Maja Pavlovic, Jasmine Wismar, Bertram Schmitt, Maria Eriksson, Per Kylsten, Mitchell S Dushay   +6 more
doaj   +1 more source

A dual role for A-type lamins in DNA double-strand break repair [PDF]

, 2011
A-type lamins are emerging as regulators of nuclear organization and function. Changes in their expression are associated with cancer and mutations are linked to degenerative diseases—laminopathies.
Biehl, Kenneth J, Feng, Zhihui, Gonzalez-Suarez, Ignacio, Gonzalo, Susana, Morgado-Palacin, Lucia, Perkins, Stephanie M, Redwood, Abena B, Roti-Roti, Joseph L, Sage, Julien, Shi, Wei, Stewart, Colin L, Vanderwaal, Robert P, Zhang, Junran   +12 more
core   +2 more sources

Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Genetic defects in nuclear lamins or reduced expression of nuclear lamins is accompanied by nuclear blebs and an increased susceptibility for nuclear membrane ruptures.
Natalie Y. Chen, Paul H. Kim, Thomas A. Weston, Lovelyn Edillo, Yiping Tu, L. Fong, S. Young   +6 more
semanticscholar   +1 more source

The Nuclear Envelope as a Regulator of Immune Cell Function

Frontiers in Immunology, 2022
The traditional view of the nuclear envelope (NE) was that it represented a relatively inert physical barrier within the cell, whose main purpose was to separate the nucleoplasm from the cytoplasm.
Anna Selezneva, Alasdair J. Gibb, Dean Willis   +2 more
doaj   +1 more source

Persistence of laminations [PDF]

Bulletin of the Brazilian Mathematical Society, New Series, 2010
We present a modern proof of some extensions of the celebrated Hirsch-Pugh-Shub theorem on persistence of normally hyperbolic compact laminations. Our extensions consist of allowing the dynamics to be an endomorphism, of considering the complex analytic case and of allowing the laminations to be non compact.
openaire   +3 more sources

Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles

Frontiers in Physiology, 2018
Since the discovery of the inner nuclear transmembrane protein emerin in the early 1990s, nuclear envelope (NE) components and related involvement in nuclei integrity and functionality have been highly investigated.
A. Janin, V. Gache
semanticscholar   +1 more source

Lamins in Lung Cancer: Biomarkers and Key Factors for Disease Progression through miR-9 Regulation?

Cells, 2018
Lung cancer represents the primary cause of cancer death in the world. Malignant cells identification and characterization are crucial for the diagnosis and management of patients with primary or metastatic cancers. In this context, the identification of
Julien Guinde, Diane Frankel, Sophie Perrin, Valérie Delecourt, Nicolas Lévy, Fabrice Barlesi, Philippe Astoul, Patrice Roll, Elise Kaspi   +8 more
doaj   +1 more source

Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits [PDF]

, 2018
Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A- and B-type lamins.
Ana, Cumano, Bartolazzi, Armando, Bucciarelli, Elisabetta, Burla, Romina, Carcuro, Mariateresa, DEL GIUDICE, Simona, Gatti, Maurizio, Giulia, Piaggio, Ilaria, Virdia, Isabella, Manni, LA TORRE, Mattia, Merigliano, Chiara, Mottini, Carla, RAMPIONI VINCIGUERRA, GIAN LUCA, Riminucci, Mara, Saggio, Isabella, Silvia, Soddu, Verni', Fiammetta, Zanetti, Giorgia   +18 more
core   +1 more source