Results 11 to 20 of about 13,685 (176)

Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes. [PDF]

FEBS Open Bio, 2019
Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed. Therefore, new therapeutic targets against leishmaniasis are required. Several isoprenoid compounds, including dolichols or ubiquinones,
Balanco JMF, Sussmann RAC, Verdaguer IB, Gabriel HB, Kimura EA, Katzin AM.   +5 more
europepmc   +5 more sources

Leishmania (L.) amazonensis LaLRR17 increases parasite entry in macrophage by a mechanism dependent on GRP78. [PDF]

Parasitology, 2023
AbstractLeishmaniases affect 12 million people worldwide. They are caused by Leishmania spp., protozoan parasites transmitted to mammals by female phlebotomine flies. During the life cycle, promastigote forms of the parasite live in the gut of infected sandflies and convert into amastigotes inside the vertebrate macrophages.
Peña MS, Tang FHF, Franco FAL, Rodrigues AT, Carrara GMP, Araujo TLS, Giordano RJ, Palmisano G, de Camargo MM, Uliana SRB, Stolf BS.   +10 more
europepmc   +4 more sources

Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2019
Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required.
Mendonça DBD, Silva REC, Palace-Berl F, Takakura CF, Soares SRC, Braz LMA, Tavares LC, Lindoso JAL.   +7 more
europepmc   +7 more sources

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection. [PDF]

Parasite Immunol
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Portugal AB, DaMatta RA, da Cunha Júnior EF, Wanderley JLM.   +3 more
europepmc   +2 more sources

Py-CoMFA, docking, and molecular dynamics simulations of Leishmania (L.) amazonensis arginase inhibitors. [PDF]

Sci Rep
AbstractLeishmaniasis is a disease caused by a protozoan of the genus Leishmania, affecting millions of people, mainly in tropical countries, due to poor social conditions and low economic development. First-line chemotherapeutic agents involve highly toxic pentavalent antimonials, while treatment failure is mainly due to the emergence of drug ...
Camargo PG, Dos Santos CR, Girão Albuquerque M, Rangel Rodrigues C, Lima CHDS.   +4 more
europepmc   +4 more sources

Metacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensis. [PDF]

Cell Death Dis, 2017
AbstractLeishmania (Leishmania) amazonensis is an important agent of cutaneous leishmaniasis in Brazil. This parasite faces cell death in some situations during transmission to the vertebrate host, and this process seems to be dependent on the activity of metacaspase (MCA), an enzyme bearing trypsin-like activity present in protozoans, plants and fungi.
Peña MS, Cabral GC, Fotoran WL, Perez KR, Stolf BS.   +4 more
europepmc   +4 more sources

Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis [PDF]

Acta Tropica, 2006
Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown.
Af Ali U M, Costa, Ana L, Abreu, Claudia M C, Gomes, Ana C R, Saldanha, A, Barral, Jackson M L, Costa, Carlos E P, Corbett   +6 more
openaire   +2 more sources

Leishmania (L.) amazonensis infection impairs reproductive and fetal parameters in female mice

Revista Argentina de Microbiología, 2021
Leishmaniasis is a group of parasitic zoonotic diseases caused by intracellular protozoans belonging to the genus Leishmania. Little is known about the effects that this parasitosis may have on the reproductive parameters and pregnancy of infected humans and pets.
Sánchez, María Belén, Germano, Maria Jose, Salomón, María Cristina, Scelta, Julieta, Garcia Bustos, Maria Fernanda, Ginevro, Paula María, Cargnelutti, Diego Esteban   +6 more
openaire   +3 more sources

Unveiling the Leishmanicidal Mechanism of 4-Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum. [PDF]

Chem Biodivers
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Lorenzetti FB, Balbinot RB, Lazarin-Bidóia D, Faiões VDS, Torres-Santos EC, Nakamura CV, Ueda-Nakamura T, Garcia Cortez DA, Dias Filho BP.   +8 more
europepmc   +2 more sources

Evaluation of Macroalgae Sulfated Polysaccharides on the Leishmania (L.) amazonensis Promastigote [PDF]

Marine Drugs, 2013
The sulfated polysaccharides from Solieria filiformis (Sf), Botryocladia occidentalis (Bo), Caulerpa racemosa (Cr) and Gracilaria caudata (Gc) were extracted and extensively purified. These compounds were then subjected to in vitro assays to evaluate the inhibition of these polysaccharides on the growth of Leishmania (L.) amazonensis promastigotes ...
Pires, Camila Lehnhardt, Rodrigues, Selma Dzimidas, Bristot, Daniel, Gaeta, Henrique Hessel, Toyama, Daniela de Oliveira, Lobo Farias, Wladimir Ronald, Toyama, Marcos Hikari   +6 more
openaire   +4 more sources