Results 21 to 30 of about 13,685 (176)

FVB/NJ strain as a mouse model for cutaneous leishmaniasis by Leishmania (L.) amazonensis. [PDF]

Mem Inst Oswaldo Cruz
Leishmaniases encompass a spectrum of neglected diseases caused by parasites of the genus Leishmania, grouped in two forms: tegumentary and visceral leishmaniasis.In this study, we propose Friend Virus B NIH Jackson (FVB/NJ) mouse strain as a new experimental model of infection with Leishmania (Leishmania) amazonensis, the second most prevalent agent ...
Carrara GMP, Stolf BS.
europepmc   +3 more sources

Leishmania (L.) amazonensis-induced inhibition of nitric oxide synthesis in host macrophages [PDF]

Microbes and Infection, 2002
Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis promastigotes. The downmodulation of NO production observed in infected and LPS-stimulated J774-G8 cells correlated with a reduction in inducible nitric oxide synthase (iNOS) activity.
Filomena M Perrella, Balestieri, Allan R Pires, Queiroz, Cristoforo, Scavone, Vlaudia M Assis, Costa, Manoel, Barral-Netto, Ises de Almeida, Abrahamsohn   +5 more
openaire   +2 more sources

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

PLOS ONE, 2015
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources. Nucleoside hydrolases release purines from nucleosides and are drug targets for anti-leishmanial drugs, absent in mammal cells.
Elisangela Oliveira Freitas, Dirlei Nico, Rong Guan, José Roberto Meyer-Fernandes, Keith Clinch, Gary B Evans, Peter C Tyler, Vern L Schramm, Clarisa B Palatnik-de-Sousa   +8 more
openaire   +4 more sources

N-acetyl-L-cysteine reduces Leishmania amazonensis-induced inflammation in BALB/c mice [PDF]

BMC Veterinary Research, 2020
AbstractBackgroundLeishmaniasis is a emergent disease characterized by different clinical manifestations in both humans and dogs. Predominant clinical features of cutaneous leishmaniasis are ulcerative painless skin lesions. Several data reported that pain is associated with human and dog leishmaniasis, out with areas of painless ulcerative lesions per
Crupi, Rosalia, Gugliandolo, Enrico, Siracusa, Rosalba, Impellizzeri, Daniela, Cordaro, Marika, Di Paola, Rosanna, Britti, Domenico, Cuzzocrea, Salvatore   +7 more
openaire   +3 more sources

The use of kDNA minicircle subclass relative abundance to differentiate between Leishmania (L.) infantum and Leishmania (L.) amazonensis. [PDF]

Parasit Vectors, 2017
Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species.
Ceccarelli M, Galluzzi L, Diotallevi A, Andreoni F, Fowler H, Petersen C, Vitale F, Magnani M.   +7 more
europepmc   +5 more sources

Putrescine supplementation shifts macrophage L-arginine metabolism related-genes reducing Leishmania amazonensis infection

PLOS ONE, 2023
Leishmania is a protozoan that causes leishmaniasis, a neglected tropical disease with clinical manifestations classified as cutaneous, mucocutaneous, and visceral leishmaniasis. In the infection context, the parasite can modulate macrophage gene expression affecting the microbicidal activity and immune response.
Jonathan Miguel Zanatta, Stephanie Maia Acuña, Yan de Souza Angelo, Camilla de Almeida Bento, Jean Pierre Schatzman Peron, Beatriz Simonsen Stolf, Sandra Marcia Muxel   +6 more
openaire   +3 more sources

Extracellular matrix alterations in experimental murine Leishmania (L.) amazonensis infection

Parasitology, 2004
Here we describe extracellular matrix alterations in footpad lesions and draining lymph nodes caused by Leishmania (L.) amazonensis in mouse strains with distinct susceptibilities to this parasite: BALB/c (susceptible), C57BL/6 (intermediate), and DBA/2 (resistant).
A L, Abreu-Silva, K S, Calabrese, R A, Mortara, R C, Tedesco, F O, Cardoso, L O P, Carvalho, S C, Gonçalves da Costa   +6 more
openaire   +2 more sources

Study of the differentially abundant proteins among Leishmania amazonensis, L. braziliensis, and L. infantum

PLOS ONE, 2020
Leishmaniasis has been considered as emerging and re-emerging disease, and its increasing global incidence has raised concerns. The great clinical diversity of the disease is mainly determined by the species. In several American countries, tegumentary leishmaniasis (TL) is associated with both Leishmania amazonensis and L.
Bruna Soares de Souza Lima, Barbara Beiral Esteves, Luiz Carlos Fialho-Júnior, Tiago Antônio de Oliveira Mendes, Simone da Fonseca Pires, Alexander Chapeourouge, Jonas Perales, Helida Monteiro de Andrade   +7 more
openaire   +4 more sources

Phage-fused epitopes from Leishmania infantum used as immunogenic vaccines confer partial protection against Leishmania amazonensis infection [PDF]

, 2016
Two mimotopes of Leishmania infantum identified by phage display were evaluated as vaccine candidates in BALB/c mice against Leishmania amazonensis infection.
Coelho, Eduardo A. F., Costa, Lourena E., Soto, Manuel   +2 more
core   +1 more source

Contribution of microscopy for understanding the mechanism of action against trypanosomatids [PDF]

, 2018
Transmission electron microscopy (TEM) has proved to be a useful tool to study the ultrastructural alterations and the target organelles of new antitrypanosomatid drugs.
A Martinez-Palomo, A Montalvetti, A Rassi, AB Penissi, AE Eakin, AH Kolien, AJ Solari, AM Sánchez, Ana Yecê das Neves Pinto, C Brack, CF Silva Da, D Gonzalez-Pacanowska, DA Campbell, DA Johnston, DJ Hammond, DV Andrade, E Bontempi, E Lozano, E Lozano, E Lozano, EO Ogbadoiyi, ES Garcia, ES Lozano, F Dos Reis, FR Opperdoes, FR Opperdoes, FR Opperdoes, FS Laranja, H Meyer, H Meyer, J Aldunate, J Lukes, J McKerrow, J Mottram, JA Urbina, JA Urbina, JA Urbina, JA Urbina, JC Engel, JC Linder, JCP Dias, JCP Dias, JD Bergstrom, JD Maya, JF Turrens, JJ Marr, JL Avila, JL Avila, Juliano de Toledo, K Lazardi, K Miranda, K Miranda, KH Lee, L Simpson, LV Muschietti, M Meirelles, M Nieto, MC Elias, MCQB Elias, MR Ariyanayagam, MR Ariyanayagam, NM Sayed El, O Campetella, OS Giordano, OS Giordano, P Barrera, P Webster, PF Pimenta, R Docampo, S Sepúlveda-Boza, SD Brengio, SR Wilkinson, T Souto-Padron, T Souto-Padron, T Souto-Padron, T Souto-Padron, TA Shapiro, TS Tiuman, V Jimenez-Ortiz, V Sülsen, VP Sülsen, VP Sülsen, VV Costantino, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, W Souza De, Wanderley de Souza, WE Gutteridge   +90 more
core   +1 more source