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Leptin receptor action and mechanisms of leptin resistance [PDF]
Cellular and Molecular Life Sciences, 2005 The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo.
Münzberg, H. +3 more
openaire +4 more sources
Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis. [PDF]
PLoS ONE, 2012 Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and ...
Bérengère Coupé +4 more
doaj +1 more source
Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA-IR in subjects of a west-African population [PDF]
, 2018 Factors associated with plasma levels of adiponectin and leptin were studied in adult subjects without diabetes from Cotonou in Benin (West‐Africa). Seventy (70) men and 45 women were included in the study.
Adehan, Grace +7 more
core +1 more source
Physiological leptin resistance [PDF]
Medycyna Weterynaryjna, 2016 Leptin is an adipose tissue-derived hormone whose circulating levels correlate with the amount of body fat stores. The main function of this adipokine is to regulate energy metabolism. By modulating the expression of orexigenic and anorexigenic neuropeptides in the hypothalamus, leptin reduces appetite.
P. Gogga +3 more
semanticscholar +3 more sources
LEPTIN RESISTANCE AND TYPE 2 DIABETES
International Journal of Medicine and Medical Research, 2017 Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat.
O. M. Oleshchuk, H. Ya. Loi
doaj +1 more source
Leptin and Its Emerging Role in Children and Adolescents [PDF]
, 2014 Leptin is an adipocyte-secreted hormone which plays a key role in energy homeostasis. Recent “proof of concept” studies involving leptin administration to humans support its critical role in regulating energy homeostasis, neuroendocrine and immune ...
Kelesidis, Iosif, Mantzoros, Christos S.
core +1 more source
International Journal of Molecular Sciences, 2021 The role of the autonomic nervous system in obesity and insulin-resistant conditions has been largely explored. However, the exact mechanisms involved in this relation have not been completely elucidated yet, since most of these mechanisms display a bi ...
B. Russo +4 more
semanticscholar +1 more source
Digested wheat gluten inhibits binding between leptin and its receptor [PDF]
, 2015 BACKGROUND: Leptin resistance is considered a primary risk factor for obesity. It has been hypothesized that dietary cereal grain protein could cause leptin resistance by preventing leptin from binding to its receptor.
Amarnadh Nalla +7 more
core +2 more sources
Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. [PDF]
, 2020 Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear.
Bouchard, Luigi +8 more
core +1 more source
The role of leptin in leptin resistance and obesity
Physiology & Behavior, 2006 Although the presence of hyperleptinemia with leptin resistance and obesity has long been recognized, a causal role of elevated leptin in these biological states remains unclear. This article summarizes some recent work from our laboratory supporting the concept that leptin, in and of itself, promotes leptin resistance and such resistance compounds the
Research Service, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States ( host institution ) +2 more
openaire +3 more sources