Results 41 to 50 of about 80,148 (202)

Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein [PDF]

, 2016
The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson's disease (PD). Rare familial PD-associated mutations in aSyn render it aggregation-prone; however, PD patients carrying wild
Boxer, Matthew B., Burlak, Christopher, Chataway, Tim, Chegini, Fariba, Cookson, Mark R., Datta, Debajyoti, Fisher, Oriana S., Gai, Wei Ping, Guo, Feng, Hoang, Quyen Q., Ju, Shulin, Landeru, Anuradha, Miller, David W., Nguyen, Linh T. T., Petsko, Gregory A., Ringe, Dagmar, Thomas, Craig J., Wang, Wei, Wells, James A., Wu, Chun-Xiang, Wu, Fang   +20 more
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Lewy Body Dementia

Annals of Medicine, 1999
Although Lewy body dementia (LBD) has received a considerable amount of interest in the last decade, there still exists a certain level of confusion concerning the clinical and neuropathological features associated with this disorder. According to many researchers, LBD represents a distinct dementing illness with specific clinical features.
openaire   +2 more sources

Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases.

PLoS ONE, 2013
ObjectiveMost neurodegenerative diseases contain hyperphosphorylated Tau [p-Tau]. We examined for the first time epitopes at which Tau is hyperphosphorylated in Parkinson's disease, dementia with Lewy bodies and Alzheimer's disease, and also select Tau ...
Valeriy Duka, Jae-Hoon Lee, Joel Credle, Jonathan Wills, Adam Oaks, Ciaran Smolinsky, Ketul Shah, Deborah C Mash, Eliezer Masliah, Anita Sidhu   +9 more
doaj   +1 more source

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
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Music Therapy Techniques for Memory Stabilization in Diverse Dementias [PDF]

, 2018
Music contains certain unmistakable healing properties pertaining specifically to the matured body and soul affected by various types of dementia. Music therapy aids in memory retention or the retarding of the loss of mental function as a result of ...
Shotts, Amanda
core   +1 more source

Cognitive dysfunction in animal models of human lewy-body dementia

Frontiers in Aging Neuroscience
Cognitive impairments are a common feature of synucleinopathies such as Parkinson’s Disease Dementia and Dementia with Lewy Bodies. These pathologies are characterized by accumulation of Lewy bodies and Lewy neurites as well as neuronal cell death. Alpha-
Caroline Haikal, Caroline Haikal, Graham M. Winston, Graham M. Winston, Michael G. Kaplitt, Michael G. Kaplitt   +5 more
doaj   +1 more source

LRRK2 in Parkinson's disease and dementia with Lewy bodies

Molecular Neurodegeneration, 2006
Background Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD).
Zhu Xiongwei, Babar Asim, Siedlak Sandra L, Yang Qiwei, Ito Genta, Iwatsubo Takeshi, Smith Mark A, Perry George, Chen Shu G   +8 more
doaj   +1 more source

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO, CONTE, MICHELA, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, FABBRINI, Giovanni, GALLO, Andrea, GRECO, Antonio, INGHILLERI, Maurizio, RIZZO, MARIA IDA, ROSATO, CHIARA   +9 more
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Exome sequencing in dementia with Lewy bodies. [PDF]

, 2016
Dementia with Lewy bodies (DLB) is the second most common form of degenerative dementia. Siblings of affected individuals are at greater risk of developing DLB, but little is known about the underlying genetic basis of the disease.
Attems, J, Ayers, KL, Burn, DJ, Chinnery, PF, Cordell, HJ, Douroudis, K, Griffin, H, Hudson, G, Hussein, RI, Keogh, MJ, Kurzawa-Akanbi, M, McKeith, IG, Morris, CM, O'Brien, JT, Pyle, A, Thomas, AJ   +15 more
core   +5 more sources

Lafora and Trétiakoff: the naming of the inclusion bodies discovered by Lewy

Arquivos de Neuro-Psiquiatria
Fritz Heinrich Jakob Lewy described, for the first time, in 1912, novel peculiar inclusions in neurons of certain brain nuclei in patients with Paralysis agitans, and compared his finding to the amyloid bodies described by Lafora one year before. Gonzalo
Eliasz Engelhardt
doaj   +1 more source