Results 31 to 40 of about 91,122 (346)
False memories in Lewy-body disease [PDF]
, 2015 Recently, de Boysson et al. (2011) [de Boysson, C., et al. (2011). False recognition in Lewy-body disease and frontotemporal dementia. Brain and Cognition, 75, 111-118.] found that patients with Lewy-body disease (LBD) showed significantly lower rates of
Abe +44 more
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Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. [PDF]
, 2019 The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles.
Brundin, P +26 more
core +3 more sources
Challenges and opportunities for improving the landscape for Lewy body dementia clinical trials
Alzheimer’s Research & Therapy, 2020 Lewy body dementia (LBD), including dementia with Lewy bodies and Parkinson’s disease dementia, affects over a million people in the USA and has a substantial impact on patients, caregivers, and society.
Jennifer G. Goldman +19 more
doaj +1 more source
Interaction between coxsackievirus B3 infection and α-synuclein in models of Parkinson’s disease
PLoS Pathogens, 2021 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. PD is pathologically characterized by the death of midbrain dopaminergic neurons and the accumulation of intracellular protein inclusions called Lewy bodies or Lewy neurites ...
Soo Jin Park, Uram Jin, Sang Myun Park
doaj +2 more sources
What Can Quantitative Gait Analysis Tell Us about Dementia and Its Subtypes? A Structured Review [PDF]
, 2017 Distinguishing dementia subtypes can be difficult due to similarities in clinical presentation. There is increasing interest in discrete gait characteristics as markers to aid diagnostic algorithms in dementia.
Galna, Brook +5 more
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Probable dementia with Lewy body [PDF]
Romanian Journal of Neurology, 2017 V.A. female, 67 years, old admitted in our clinic for neurological assessment because of a Parkinson syndrome, in association with neurocognitive disorder established in a psychiatric service.
Irene Davidescu
doaj +1 more source
Alzheimer’s Research & Therapy, 2022 Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice.
John T. O’Brien +5 more
doaj +1 more source
Kinematic analysis of handwriting movements in patients with Alzheimer's disease, mild cognitive impairment, depression and healthy subjects [PDF]
, 2003 A variety of studies have demonstrated that motor disorders, parkinsonism and extrapyramidal motor symptoms (EPMS) are common in patients with Alzheimer's disease (AD).
Burger, K. +5 more
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Neuropathological evidence of body-first vs. brain-first Lewy body disease
Neurobiology of Disease, 2021 Aggregation of alpha-synuclein into inclusion bodies, termed Lewy pathology, is a defining feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB).
Per Borghammer +7 more
doaj +1 more source
Journal of Neurology, Neurosurgery & Psychiatry, 2001 James Parkinson noted: “A diseased state of the medulla spinalis, in that part which is contained in the canal, formed by the superior cervical vertebrae, and extending, as the disease proceeds, to the medulla oblongata . . .is the proximate cause.”1 In the late 19th century, because knowledge of the pathophysiology of the basal ganglia was imprecise,
openaire +2 more sources