The LINC Complex Inhibits Excessive Chromatin Repression [PDF]
Cells, 2023 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex transduces nuclear mechanical inputs suggested to control chromatin organization and gene expression; however, the underlying mechanism is currently unclear.
Daria Amiad Pavlov +8 more
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Life at the crossroads: the nuclear LINC complex and vascular mechanotransduction [PDF]
Frontiers in PhysiologyVascular endothelial cells line the inner surface of all blood vessels, where they are exposed to polarized mechanical forces throughout their lifespan.
Pauline Bougaran +2 more
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Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary [PDF]
Cells, 2022 Mutations in genes encoding proteins associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex within the nuclear envelope cause different diseases with varying phenotypes including skeletal muscle, cardiac, metabolic, or nervous ...
Emily C. Storey, Heidi R. Fuller
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The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal [PDF]
Scientific Reports, 2021 The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive.
Miki Hieda +11 more
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Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1 [PDF]
Frontiers in Cell and Developmental Biology, 2023 The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Manickam Gurusaran +3 more
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LINC complex alterations are a key feature of sporadic and familial ALS/FTD [PDF]
Acta Neuropathologica CommunicationsAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research
Riccardo Sirtori +5 more
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A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies [PDF]
eLife, 2021 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of cellular functions, including nuclear shape and positioning, hearing, and meiotic ...
Manickam Gurusaran, Owen Richard Davies
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Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro [PDF]
CellsEukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope lumen.
Natalie Young +11 more
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The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation [PDF]
Stem Cell Research & TherapyBackground Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses.
Xuehuan Meng +9 more
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The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation [PDF]
eLife, 2021 While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood.
Emma Carley +8 more
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