Results 191 to 198 of about 7,490 (198)

Structural studies on the LINC complex and Fic-1

2015
LINC complexes span the nuclear envelope and connect the nucleoskeleton to the cytoskeleton. In 2012, our lab solved the first LINC complex structure, that of SUN domain of human SUN2 bound with KASH1 or KASH2 peptides. In this project testes-specific human SUN proteins (SUN3, SPAG4, and SUNS) were compared to ubiquitously-expressed SUN2.
openaire   +1 more source

Conserved SUN-KASH Interfaces Mediate LINC Complex-Dependent Nuclear Movement and Positioning

Current Biology, 2018
Mohammad R K Mofrad, Daniel Starr, Gw Gant Luxton   +2 more
exaly  

Disrupting the LINC complex for treating laminopathy

2019
STEWART COLIN LAWSON, CHAI JINFEN, LEE YIN LOON, BURKE BRIAN EDMUND   +3 more
openaire   +8 more sources

Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin‐2 in breast cancer

Cancer Medicine, 2015
Miki Matsumura
exaly  

Role of LINC complex in YAP/TAZ mechanotransduction

The ability of cells to respond and adapt to different external mechanical stimuli converting them into biochemical signals falls under the name of mechanotransduction (Discher et al., 2009). Pivotal in such phenomenon are YAP and TAZ, transcriptional co-regulators whose activation is driven by nuclear accumulation triggered by external mechanical ...
openaire   +1 more source

TREATMENT/PREVENTION OF DISEASE BY LINC COMPLEX INHIBITION

2021
STEWART COLIN LAWSON, SINGARAJA ROSHNI, BURKE BRIAN, LEE YIN LOON, TAN YANN CHONG   +4 more
openaire   +5 more sources

LINC02454-CCT complex interaction is essential for telomerase activity and cell proliferation in head and neck squamous cell carcinoma

Cancer Letters
Ming Xu, Yanjie Zhang, Biying Chen
exaly  

Linc Complex and Microtubule nucleation in muscle cells

2017
openaire   +1 more source