Results 191 to 200 of about 8,120 (205)
Some of the next articles are maybe not open access.
Role of LINC complex proteins in sperm formation
Medicine of Extreme Situations, 2022Spermatogenesis is characterized by the significant changes of three-dimensional organization of the nucleus in spermatocytes, spermatides and spermatozoa. The functional cooperation between the nuclear envelope proteins and the acroplaxome/manchette is essential for nuclear elongation, acrosome biogenesis, formation of the flagellum.
SYu Kurchashova, TV Gasanova, EE Bragina
openaire +1 more source
LINC complexes as regulators of meiosis
Current Opinion in Cell Biology, 2018Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic recombination and shuffling of ...
openaire +2 more sources
EM Tomography of Meiotic LINC Complexes
2018Electron microscope (EM) tomography is a powerful technique that enables the three-dimensional analysis of subcellular structures at high resolution. We have applied this method to the quantitative analysis of LINC complex distribution and interaction with the cytoskeleton in meiotic cells from male mice.
Marie-Christin, Spindler +3 more
openaire +2 more sources
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2013 ObjectivesThe human genome encodes many long intergenic noncoding RNAs (lincRNAs). However, their biological functions, molecular mechanisms and prognostic values associated with bladder cancer remain to be elucidated.
Wang He +2 more
exaly +2 more sources
Recombinant Purification of the Periplasmic Portion of the LINC Complex
2018Recombinant expression of proteins and their complexes is the routine laboratory procedure to generate pure reagents for biochemical and structural studies. Here we present the standard procedure developed in our lab for the production of milligram quantities of stoichiometric SUN-KASH complexes.
Victor E, Cruz, Thomas U, Schwartz
openaire +2 more sources
Analyzing Mechanotransduction Through the LINC Complex in Isolated Nuclei
2018The mechanical properties of the cellular microenvironment can impact many aspects of cell behavior, including molecular processes in the nucleus. Recent studies indicate that the LINC complex and its associated nuclear envelope transmit and transduce mechanical stress into biochemical pathways that ultimately regulate nuclear structure or gene ...
Nejma, Belaadi +3 more
openaire +2 more sources
Dynamic regulation of LINC complex composition and function across tissues and contexts
FEBS Letters, 2023Megan C KING
exaly
LINC complex alterations are a hallmark of sporadic and familial ALS/FTD
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that primarily affects motor neurons, leading to progressive muscle weakness and loss of voluntary muscle control. While the exact cause of ALS is not fully understood, emerging research suggests that dysfunction of the nuclear envelope (NE ...Riccardo Sirtori +5 more
openaire +2 more sources