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The role of nesprin and the LINC complex in cardiomyocyte mechanotransduction
Journal of Molecular and Cellular Cardiology PlusCan Zhou +6 more
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Cell stretchers and the LINC complex in mechanotransduction
Archives of Biochemistry and Biophysics, 2021 How cells respond to mechanical forces from the surrounding environment is critical for cell survival and function. The LINC complex is a central component in the mechanotransduction pathway that transmits mechanical information from the cell surface to the nucleus. Through LINC complex functionality, the nucleus is able to respond to mechanical stress
Henning Horn +2 more
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The assembly of a noncanonical LINC complex in Saccharomyces cerevisiae
Current Genetics, 2021The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex across the nuclear envelope and has maintained its general assembly mode throughout evolution. SUN and KASH proteins, which are the major components of LINC complex, interact with each other in the nuclear lumen to transmit forces across the nuclear envelope and have ...
Yang Wang, Jinbo Fan, Zhuo Sun
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LINC Complex Proteins in Development and Disease
Current Topics in Developmental Biology, 2014The LINC complex spans the nuclear envelope and plays critical roles in coordinating nuclear and cytoplasmic activities and in organizing nuclear and cytoskeletal features. LINC complexes are assembled from KASH and SUN-domain proteins, which interact in the nuclear envelope and form a physical link between the cytoskeleton and the nuclear interior.
Henning Horn
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LINC complex regulation of genome organization and function
Current Opinion in Genetics & Development, 2021The regulation of genomic function is in part mediated through the physical organization and architecture of the nucleus. Disruption to nuclear organization and architecture is increasingly being recognized by its contribution to many diseases. The LINC complexes - protein structures traversing the nuclear envelope, that physically connect the nuclear ...
Xianrong, Wong +2 more
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The LINC complex and human disease
Biochemical Society Transactions, 2011The LINC (linker of nucleoskeleton and cytoskeleton) complex is a proposed mechanical link tethering the nucleo- and cyto-skeleton via the NE (nuclear envelope). The LINC components emerin, lamin A/C, SUN1, SUN2, nesprin-1 and nesprin-2 interact with each other at the NE and also with other binding partners including actin filaments and B-type lamins ...
Peter, Meinke +2 more
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The role of the LINC complex in ageing and microgravity
Mechanisms of Ageing and DevelopmentThe Linker of Nucleoskeleton and Cytoskeleton (LINC) complex plays a crucial role in connecting the nuclear envelope to the cytoskeleton, providing structural support to the nucleus and facilitating mechanical signaling between the extracellular environment and the nucleus. Research in mechanobiology onboard the International Space Station (ISS) and in
Jjwa Van Loon
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LINC complexes and nuclear positioning
Seminars in Cell & Developmental Biology, 2018One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through dermal differentiation in nematodes,
Yin Loon, Lee, Brian, Burke
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2023
Apicomplexan parasites include some of the most important pathogens, such as Plasmodium spp., the causative agent of malaria, or Toxoplasma gondii, the causative agent of toxoplasmosis. As obligate intracellular parasites, Apicomplexa invade host cells in an active process, where they replicate within a parasitophorous vacuole, followed by egress and ...
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Apicomplexan parasites include some of the most important pathogens, such as Plasmodium spp., the causative agent of malaria, or Toxoplasma gondii, the causative agent of toxoplasmosis. As obligate intracellular parasites, Apicomplexa invade host cells in an active process, where they replicate within a parasitophorous vacuole, followed by egress and ...
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Recombinant Purification of the Periplasmic Portion of the LINC Complex
Methods in Molecular Biology, 2018Recombinant expression of proteins and their complexes is the routine laboratory procedure to generate pure reagents for biochemical and structural studies. Here we present the standard procedure developed in our lab for the production of milligram quantities of stoichiometric SUN-KASH complexes.
Thomas U Schwartz, VĂCTOR E Cruz
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