Results 181 to 190 of about 8,120 (205)
The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair. [PDF]
Exp Biol Med (Maywood), 2019 Lambert MW.
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The role of nesprin and the LINC complex in cardiomyocyte mechanotransduction
Journal of Molecular and Cellular Cardiology PlusCan Zhou +6 more
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Cell stretchers and the LINC complex in mechanotransduction [PDF]
Archives of Biochemistry and Biophysics, 2021 How cells respond to mechanical forces from the surrounding environment is critical for cell survival and function. The LINC complex is a central component in the mechanotransduction pathway that transmits mechanical information from the cell surface to ...
Abdulghani A Khilan +2 more
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The role of the LINC complex in ageing and microgravity
Mechanisms of Ageing and DevelopmentThe Linker of Nucleoskeleton and Cytoskeleton (LINC) complex plays a crucial role in connecting the nuclear envelope to the cytoskeleton, providing structural support to the nucleus and facilitating mechanical signaling between the extracellular ...
Jack J W A Van Loon
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The assembly of a noncanonical LINC complex in Saccharomyces cerevisiae
Current Genetics, 2021The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex across the nuclear envelope and has maintained its general assembly mode throughout evolution. SUN and KASH proteins, which are the major components of LINC complex, interact with each other in the nuclear lumen to transmit forces across the nuclear envelope and have ...
Jinbo Fan, Zhuo Sun, Yang Wang
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LINC Complex Proteins in Development and Disease
Current Topics in Developmental Biology, 2014The LINC complex spans the nuclear envelope and plays critical roles in coordinating nuclear and cytoplasmic activities and in organizing nuclear and cytoskeletal features. LINC complexes are assembled from KASH and SUN-domain proteins, which interact in the nuclear envelope and form a physical link between the cytoskeleton and the nuclear interior.
Henning F Horn
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Accessorizing and anchoring the LINC complex for multifunctionality [PDF]
Journal of Cell Biology, 2015 The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome ...
Wakam Chang +2 more
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LINC complex regulation of genome organization and function
Current Opinion in Genetics & Development, 2021The regulation of genomic function is in part mediated through the physical organization and architecture of the nucleus. Disruption to nuclear organization and architecture is increasingly being recognized by its contribution to many diseases. The LINC complexes - protein structures traversing the nuclear envelope, that physically connect the nuclear ...
Xianrong, Wong +2 more
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LINC complexes and nuclear positioning
Seminars in Cell & Developmental Biology, 2018One of the characteristics of eukaryotic cells is their structural plasticity associated with the ability to carry out a broad range of complex functions, both autonomously and as components of tissues and organs. Major cellular rearrangements can be observed in various systems from meiosis in fission yeast, through dermal differentiation in nematodes,
Yin Loon, Lee, Brian, Burke
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2023
Apicomplexan parasites include some of the most important pathogens, such as Plasmodium spp., the causative agent of malaria, or Toxoplasma gondii, the causative agent of toxoplasmosis. As obligate intracellular parasites, Apicomplexa invade host cells in an active process, where they replicate within a parasitophorous vacuole, followed by egress and ...
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Apicomplexan parasites include some of the most important pathogens, such as Plasmodium spp., the causative agent of malaria, or Toxoplasma gondii, the causative agent of toxoplasmosis. As obligate intracellular parasites, Apicomplexa invade host cells in an active process, where they replicate within a parasitophorous vacuole, followed by egress and ...
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