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Functional Analysis of LINC Complexes in the Skin
2018The genome in eukaryotic cells is encased by two intricate and interconnected concentric membranes, which together with the underlying nuclear lamina form the nuclear envelope (NE). Two fundamental macromolecular structures are embedded within the nuclear envelope: the nuclear pore (NPC) and the LINC complex.
Iakowos, Karakesisoglou +2 more
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EM Tomography of Meiotic LINC Complexes
2018Electron microscope (EM) tomography is a powerful technique that enables the three-dimensional analysis of subcellular structures at high resolution. We have applied this method to the quantitative analysis of LINC complex distribution and interaction with the cytoskeleton in meiotic cells from male mice.
Marie-Christin, Spindler +3 more
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LINC complexes as regulators of meiosis
Current Opinion in Cell Biology, 2018Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic recombination and shuffling of ...
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Role of LINC complex proteins in sperm formation
Medicine of Extreme Situations, 2022Spermatogenesis is characterized by the significant changes of three-dimensional organization of the nucleus in spermatocytes, spermatides and spermatozoa. The functional cooperation between the nuclear envelope proteins and the acroplaxome/manchette is essential for nuclear elongation, acrosome biogenesis, formation of the flagellum.
SYu Kurchashova, TV Gasanova, EE Bragina
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Analyzing Mechanotransduction Through the LINC Complex in Isolated Nuclei
2018The mechanical properties of the cellular microenvironment can impact many aspects of cell behavior, including molecular processes in the nucleus. Recent studies indicate that the LINC complex and its associated nuclear envelope transmit and transduce mechanical stress into biochemical pathways that ultimately regulate nuclear structure or gene ...
Nejma, Belaadi +3 more
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Dynamic regulation of LINC complex composition and function across tissues and contexts
FEBS Letters, 2023Megan KING
exaly
The molecular basis of LINC complex formation
2014The nucleus is the hallmark of the eukaryotic cell. It contains most of the genetic material and it separates the processes of replication and transcription from that of translation. Communication between the nucleus and the cytoplasm occurs mostly through openings in the nuclear envelope composed of nuclear pore complexes.
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Signal Transduction across the Nuclear Envelope: Role of the LINC Complex in Bidirectional Signaling
Cells, 2019Miki Matsumura
exaly