Results 21 to 30 of about 21,470 (214)
Life outside the LINC complex - Do SUN proteins have LINC-independent functions? [PDF]
BioessaysAbstractSad1 and UNC84 (SUN) and Klarsicht, ANC‐1, and Syne homology (KASH) proteins interact at the nuclear periphery to form the linker of nucleoskeleton and cytoskeleton (LINC) complex, spanning the nuclear envelope (NE) and connecting the cytoskeleton with the nuclear interior.
Belaadi N, Guilluy C.
europepmc +3 more sources
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy [PDF]
Nature Communications, 2021 Yin Loon Lee +2 more
exaly +2 more sources
The LINC complex ensures accurate centrosome positioning during prophase
Life Science Alliance, 2023 Abstract Accurate centrosome separation and positioning during early mitosis relies on force- generating mechanisms regulated by a combination of extracellular, cytoplasmic, and nuclear cues. The identity of the nuclear cues involved in this process remains largely unknown.
Lima JT, Pereira AJ, Ferreira JG.
europepmc +3 more sources
Histone methyltransferase SUV39H1 regulates the Golgi complex via the nuclear envelope-spanning LINC complex. [PDF]
PLoS One, 2023 AbstractCell motility is related to the higher-order structure of chromatin. Stimuli that induce cell migration change chromatin organization; such stimuli include elevated histone H3 lysine 9 trimethylation (H3K9me3). We previously showed that depletion of histone H3 lysine 9 methyltransferase, SUV39H1, suppresses directional cell migration.
Nishino M +6 more
europepmc +3 more sources
Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. [PDF]
PLoS ONE, 2018 LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements.
Christopher K May, Christopher W Carroll
doaj +1 more source
Structural insights into LINC complexes [PDF]
Current Opinion in Structural Biology, 2013 Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH ...
Kutay, Ulrike +2 more
openaire +4 more sources
Frontiers in Plant Science, 2021 In eukaryotes, the nuclear envelope (NE) encloses chromatin and separates it from the rest of the cell. The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex physically bridges across the NE, linking nuclear and cytoplasmic components.
Joseph F. McKenna +6 more
doaj +1 more source
LINC complexes in health and disease [PDF]
Nucleus, 2010 The cell nucleus communicates with the rest of the cell via nucleo/cytoplasmic transport of proteins and RNA through the nuclear pores. Direct mechanical links between the nucleus and the cytoplasm have recently emerged in the form of LINC (Linkers of the nucleoskeleton to the cytoskeleton) protein complexes. A LINC complex consists of four components.
Mejat, Alexandre, Misteli, Tom
openaire +3 more sources
LINCing complex functions at the nuclear envelope [PDF]
Nucleus, 2013 Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements.
Rothballer Andrea +2 more
openaire +4 more sources
LINCing Senescence and Nuclear Envelope Changes
Cells, 2022 The nuclear envelope (NE) has emerged as a nexus for cellular organization, signaling, and survival. Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE’s role in supporting and maintaining a myriad of other functions has ...
Bakhita R. M. Meqbel +4 more
doaj +1 more source