Results 31 to 40 of about 21,470 (214)

The LINC complex is essential for hearing [PDF]

Journal of Clinical Investigation, 2013
Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM ...
Henning F, Horn, Zippora, Brownstein, Danielle R, Lenz, Shaked, Shivatzki, Amiel A, Dror, Orit, Dagan-Rosenfeld, Lilach M, Friedman, Kyle J, Roux, Serguei, Kozlov, Kuan-Teh, Jeang, Moshe, Frydman, Brian, Burke, Colin L, Stewart, Karen B, Avraham   +13 more
openaire   +2 more sources

Molecular Mechanisms of Mechanotransduction through LINC Complexes [PDF]

Biophysical Journal, 2016
The coupling of the cytoskeleton and nucleoskeleton is ultimately mediated by LINC complexes that are formed by a strong interaction between SUN domain and KASH domain proteins in the nuclear envelope. Their pivotal roles in cellular mechanotransduction and nuclear positioning have only been identified after their discovery in the past decade.
Jahed, Zeinab, Shams, Hengameh, Mofrad, Mohammad   +2 more
openaire   +4 more sources

Cell stretchers and the LINC complex in mechanotransduction

Archives of Biochemistry and Biophysics, 2021
How cells respond to mechanical forces from the surrounding environment is critical for cell survival and function. The LINC complex is a central component in the mechanotransduction pathway that transmits mechanical information from the cell surface to the nucleus. Through LINC complex functionality, the nucleus is able to respond to mechanical stress
Abdulghani A. Khilan, Noor A. Al-Maslamani, Henning F. Horn   +2 more
openaire   +2 more sources

Implications for Diverse Functions of the LINC Complexes Based on the Structure

Cells, 2017
The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins.
Miki Hieda
doaj   +1 more source

Medicago LINC complexes function in nuclear morphology, nuclear movement, and root nodule symbiosis 1[OPEN] [PDF]

, 2018
Nuclear movement is involved in cellular and developmental processes across eukaryotic life, often driven by Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes, which bridge the nuclear envelope (NE) via the interaction of Klarsicht/ ANC-1/Syne-1
Cerro Sánchez, Pablo del, Charpentier, Myriam, Meier, Iris, Newman-Griffis, Anna H.   +3 more
core   +1 more source

The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity [PDF]

, 2017
Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system. Dysregulated lncRNA expression has been documented in several human cancers, and their tissue-specificity
Alfano, Vincenzo, Bevilacqua, Valeria, Bozzoni, Irene, Caffarelli, Elisa, Carai, Andrea, Carlo, Valerio Di, Favia, Annarita, Ferretti, Elisabetta, Laneve, Pietro, Legnini, Ivano, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese, Rea, Jessica   +14 more
core   +1 more source

The plant LINC complex at the nuclear envelope [PDF]

Chromosome Research, 2014
Significant advances in understanding the plant nuclear envelope have been made over the past few years; indeed, knowledge of the protein network at the nuclear envelope is rapidly growing. One such network, the linker of nucleoskeleton and cytoskeleton (LINC) complex, is known in animals to connect chromatin to the cytoskeleton through the nuclear ...
Tatout, Christophe, Evans, David E, Vanrobays, Emmanuel, Probst, Aline V, Graumann, Katja   +4 more
openaire   +3 more sources

Mouse models of nesprin-related diseases [PDF]

, 2018
Nesprins (nuclear envelope spectrin repeat proteins) are a family of multi-isomeric scaffolding proteins. Nesprins form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) complex with SUN (Sad1p/UNC84) domain-containing proteins at the nuclear envelope,
Akinrinade, Arsenovic, Attali, Baird, Banerjee, Baumann, Baye, Behrens, Can Zhou, Catherine M. Shanahan, Chen, Crisp, Derek T. Warren, Djinovic Carugo, Duong, Espigat-Georger, Fanin, Fridolfsson, Gimpel, González, Gough, Grady, Green, Gros-Louis, Guilluy, Haque, Haskell, Hockemeyer, Holt, Horn, Horn, Izumi, Johnson, Ketema, Ketema, Kosodo, Laquerriere, Lee, Lee, Li Rao, Lindeman, Luke, Mellad, Merrell, Mislow, Mitzner, Morgan, Morimoto, Neumann, Noreau, O'Roak, Olins, Ozaki, Puckelwartz, Puckelwartz, Qiuping Zhang, Rajgor, Rajgor, Razafsky, Razafsky, Razafsky, Razafsky, Razafsky, Rosenberg-Hasson, Roux, Shindo, Sosa, Sosa, Starr, Stierle, Stroud, Synofzik, Taniura, van Berlo, Voit, Warren, Warren, Wilhelmsen, Wilson, Winder, Wynshaw-Boris, Yang, Yu, Yu, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhen, Zhong, Zhou, Zhou   +93 more
core   +1 more source

Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in γ-Irradiation-Induced Senescent Cells

Cells, 2020
Cellular senescence, induced by genotoxic or replication stress, is accompanied by defects in nuclear morphology and nuclear membrane-heterochromatin disruption.
Alena Svobodová Kovaříková, Eva Bártová, Aleš Kovařík, Emilie Lukášová   +3 more
doaj   +1 more source

Accessorizing and anchoring the LINC complex for multifunctionality [PDF]

Journal of Cell Biology, 2015
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome ...
Chang, Wakam, Worman, Howard J., Gundersen, Gregg G.   +2 more
openaire   +2 more sources