Results 101 to 110 of about 277,444 (259)

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Linear energy transfer-inclusive models of brainstem necrosis following proton therapy of paediatric ependymoma. [PDF]

Phys Imaging Radiat Oncol, 2023
Handeland AH, Indelicato DJ, Fredrik Fjæra L, Ytre-Hauge KS, Pettersen HES, Muren LP, Lassen-Ramshad Y, Stokkevåg CH.   +7 more
europepmc   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Analog ReLU Activation Enabled by Van Hove Singularities in a Kagome Semiconductor Field‐Effect Transistor

Advanced Electronic Materials
With the growing demand for high‐performance computing in deep learning, energy‐efficient analog computing has emerged as a promising alternative to conventional energy‐intensive digital processing.
Ziyuan Meng, Hang Xu, Xueli Geng, Zhaoying Ren, Haifeng Feng, Kunrong Du, Zhijian Shi, Wei Cai, Zhe Sun, Hongrun Zhang, Anping Huang, Feng Cheng, Binghui Ge, Yi Du, Weichang Hao   +14 more
doaj   +1 more source

Calculating dose-averaged linear energy transfer in an analytical treatment planning system for carbon-ion radiotherapy. [PDF]

J Appl Clin Med Phys, 2023
Wang W, Li P, Shahnazi K, Wu X, Zhao J.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Proton linear energy transfer and variable relative biological effectiveness for adolescent patients with Hodgkin lymphoma. [PDF]

BJR Open, 2023
Rechner LA, Maraldo MV, Smith EA, Lundgaard AY, Hjalgrim LL, MacKay RI, Aitkenhead AH, Aznar MC.   +7 more
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Treatment-planning approaches to intensity modulated proton therapy and the impact on dose-weighted linear energy transfer. [PDF]

J Appl Clin Med Phys, 2023
Faught AM, Wilson LJ, Gargone M, Pirlepesov F, Moskvin VP, Hua CH.   +5 more
europepmc   +1 more source