Results 111 to 120 of about 2,488,943 (332)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: a European multi-centric study

Acta oncologica, 2021
C. Hahn, Jakob Ödén, A. Dasu, A. Vestergaard, M. Fuglsang Jensen, Olga Sokol, C. Pardi, F. Bourhaleb, A. Leite, L. de Marzi, E. Smith, Adam Henry Aitkenhead, C. Rose, M. Merchant, K. Kirkby, L. Grzanka, J. Pawelke, A. Lühr   +17 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Long-range Energy Transfer and Ionization in Extended Quantum Systems Driven by Ultrashort Spatially Shaped Laser Pulses

, 2011
The processes of ionization and energy transfer in a quantum system composed of two distant H atoms with an initial internuclear separation of 100 atomic units (5.29 nm) have been studied by the numerical solution of the time-dependent Schr\"odinger ...
André D. Bandrauk, Bandrauk, Bandrauk, Bandrauk, Cederbaum, Chelkowski, Došlić, Guennaddi K. Paramonov, Havermeier, Ishikawaa, Jahnke, Jahnke, Kaluža, Lablanquie, Marburger, Morishita, Oliver Kühn, Paramonov, Paramonov, Paramonov, Prasad, Sisourat   +21 more
core   +1 more source

Paradigm Shift in Radiation Biology/Radiation Oncology—Exploitation of the “H2O2 Effect” for Radiotherapy Using Low-LET (Linear Energy Transfer) Radiation such as X-rays and High-Energy Electrons

Cancers, 2016
Most radiation biologists/radiation oncologists have long accepted the concept that the biologic effects of radiation principally involve damage to deoxyribonucleic acid (DNA), which is the critical target, as described in “Radiobiology for the ...
Y. Ogawa
semanticscholar   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Plasmons and Interband Transitions of Ca$_{11}$Sr$_3$Cu$_{24}$O$_{41}$ investigated by Electron Energy-Loss Spectroscopy

, 2010
Electron energy-loss spectroscopy studies have been performed in order to get a deeper insight into the electronic structure and elementary excitations of the two-leg ladder system Ca$_{11}$Sr$_3$Cu$_{24}$O$_{41}$. We find a strong anisotropy of the loss
Alexandre Revcolevschi, Bernd Büchner, Christian Hess, D. Pines, Friedrich Roth, J. Fink, Martin Knupfer, Udo Ammerahl   +7 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Linear energy transfer optimized proton therapy for rectal cancer

Radiotherapy and Oncology
To evaluate the feasibility and utility of an LET-optimized proton treatment planning algorithm in locally advanced rectal cancer and to assess whether the degree of LET-optimization achieved in clinical plans improves efficacy and toxicity in preclinical models.A series of five rectal cancer patients treated with standard 25 fraction clinical proton ...
Jiasen Ma, Sonja Dragojevic, Nicholas B. Remmes, Nicole L. Mendelson, Jake A. Kloeber, Daniel K. Ebner, Zheming Wu, Heather J. Gunn, Kenneth W. Merrell, Christopher L. Hallemeier, Michael G. Haddock, Krishan R. Jethwa, Zhenkun Lou, Robert W. Mutter, Cameron M. Callaghan   +14 more
openaire   +2 more sources

Dependence and independence of survival parameters on linear energy transfer in cells and tissues

Journal of Radiation Research, 2016
Carbon-ion radiotherapy has been used to treat more than 9000 cancer patients in the world since 1994. Spreading of the Bragg peak is necessary for carbon-ion radiotherapy, and is designed based on the linear–quadratic model that is commonly used for ...
K. Ando, D. Goodhead
semanticscholar   +1 more source