Results 101 to 110 of about 10,676,082 (292)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Effectiveness of double-layer beam shaping assembly neutron beam for boron neutron capture therapy: A microdosimetric study using particle and heavy ion transport code system [PDF]

Ядерна фізика та енергетика
Boron neutron capture therapy (BNCT) is a cancer therapy currently under development. The key to successful BNCT therapy depends on the ability of 10B to be distributed within cells and the quality of the neutrons being used.
Bilalodin, F. Abdullatif, P. Lestari, S. Nurhayati, Zusfahair, Y. Sarjono, R. Tursinah   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Nonlinear oscillations of rectangular plate with 1:3 internal resonance between different modes

Results in Physics, 2018
The energy transfer between different modes of rectangular plate with 1:3 internal resonance is investigated. The ordinary differential equations of motion for the plate are worked out by applying the Galerkin’s method.
Min Sun, Tingting Quan, Dongmei Wang
doaj   +1 more source

Granular Crystals: Controlling Mechanical Energy with Nonlinearity and Discreteness [PDF]

, 2011
The presence of structural discreteness and periodicity can affect the propagation of phonons, sound, and other mechanical waves. A fundamental property of many of the periodic structures and materials designed for this purpose is the presence of ...
Boechler, Nicholas Sebastian
core   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Using single-sample networks and genetic algorithms to identify radiation-responsive genes in rice affected by heavy ions of the galactic cosmic radiation with different LET values

Frontiers in Plant Science
IntroductionHeavy ions of the galactic cosmic radiation dominate the radiation risks and biological effects for plants under spaceflight conditions. However, the biological effects and sensitive genes caused by heavy ions with different linear energy ...
Yan Zhang, Wei Wang, Meng Zhang, Binquan Zhang, Shuai Gao, Meng Hao, Dazhuang Zhou, Lei Zhao, Guenther Reitz, Guenther Reitz, Yeqing Sun   +10 more
doaj   +1 more source

An overview of collective effects in circular and linear accelerators [PDF]

, 1989
The purpose of both linear and circular accelerator is, of course, to accelerate beams of charged particles. In order to do this it is necessary not only to accelerate particles but also to confine them transversely so that they remain in the vacuum ...
Ruth, R.D. (Stanford Linear Accelerator Center, Menlo Park, CA (USA))
core  

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Dendrimer Analogues of Linear Molecules to Evaluate Energy and Charge-Transfer Properties

, 2016
We have designed and synthesized difunctionalized dendrimers containing two donors in the periphery and an acceptor at the core to serve as scaffolds for comparison with linear analogues to investigate the advantage of dendritic scaffolds for energy and ...
Rabih Al-Kaysi (2536807), Arpornrat Nantalaksakul (2086084), Raghunath Reddy Dasari (2536810), Christopher J. Bardeen (1358100), S. Thayumanavan (1269861), Tai-Sang Ahn (2536804)   +5 more
core   +2 more sources