Results 71 to 80 of about 2,219,397 (166)

In vitro and in vivo synergistic effects of cyclizine and piroxicam in combination with linezolid against methicillin-resistant Staphylococcus aureus

Applied Microbiology and Biotechnology
Background Linezolid (LNZ) is considered one of the last-resort antimicrobial agents reserved for treating methicillin resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA).
Mai A. Moawad, Abeer M. Abd El-Aziz, Mona I. Shaaban   +2 more
doaj   +1 more source

Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei, Liangbin Lin, Peidong Pu, Jie Chen, Xianchao Su, Shubao Liu, Yanli Tong, Hui Yu   +7 more
wiley   +1 more source

Antimicrobial Resistance in Nontyphoidal Salmonella and Clinically Relevant Enterococcus From Faecal Samples of Conservation‐Priority Captive Ungulates in a United Arab Emirates Urban Zoo: A Cross‐Sectional Baseline Study

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Targeted faecal surveillance of conservation‐priority captive ungulates identified multidrug‐resistant nontyphoidal Salmonella and clinically relevant Enterococcus in a UAE urban zoo. These findings provide cross‐sectional baseline evidence supporting cautious integration of zoo‐based monitoring into One Health antimicrobial resistance surveillance ...
Ihab Habib, Moneeb A. Qablan, Fatema Aaref Alzaabi, Fatema Rashed Alnuaimi, Ghalya Ahmed Almemari, Glindya Bhagya Lakshmi, Safeya Al Naqbi, Fatima Al Shamsi, Dhanya Vijay, John Mhongovoyo, Sultan Khalifa Alkaabi, Amna Mana Alotaiba   +11 more
wiley   +1 more source

First detection of an optrA-positive, linezolid-resistant ST16 Enterococcus faecalis from human in Greece

New Microbes and New Infections, 2019
Until now, in Greece, the resistance of enterococci to linezolid was associated with mutations of domain V of 23S ribosomal RNA (G2576T). Here we report the first linezolid-resistant optrA-positive Enterococcus faecalis sequence type (ST) 16 isolated ...
K. Tsilipounidaki, A. Gerontopoulos, C. Papagiannitsis, E. Petinaki   +3 more
doaj   +1 more source

A Multi‐Scale Computational Framework for Anti‐Persister Tuberculosis Drug Discovery

Chemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
This review presents an integrated QSAR–scaffold design–docking–MD framework for discovering anti‐persister tuberculosis agents active in dormant granuloma‐like conditions. By targeting Mtb bioenergetics and prioritising dual NDH‐2/cytochrome bd oxidase inhibition, the workflow advances rational design of candidates with higher resistance barriers ...
Said Moshawih, Anguraj Moulishankar, Chee Yan Choo, Khang Wen Goh, Chrismawan Ardianto, Azam Che Idris, Long Chiau Ming   +6 more
wiley   +1 more source

Linezolid-associated optic neuropathy cascade in DR-TB patients, Mumbai, India.

, 2016
Linezolid-associated optic neuropathy cascade in DR-TB patients, Mumbai, India.
Mrinalini Das (475810), Salil Mehta (3111570), Petros Isaakidis (316418), Chinmay Laxmeshwar (3111567), Sein Sein Thi (3111576), Sylvie Jonckheere (3111573)   +5 more
core   +1 more source

Characterization of linezolid- and methicillin-resistant coagulase-negative staphylococci in a tertiary hospital in China

BMC Infectious Diseases
Background Recently, linezolid-resistant staphylococci have become an emerging problem worldwide. Understanding the mechanisms of resistance, molecular epidemiology and transmission of linezolid-resistant CoNS in hospitals is very important.
Cailin Liu, Jing Yu, Chunguang Chen, Xiaogai Li, Yafei Ye, Yani Dong, Xinxin Ying, Haijun Li, Wanhai Wang   +8 more
doaj   +1 more source

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

Hemodialysis International, Volume 30, Issue 4, Page 679-688, October 2026.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra, Jordan Fangue‐Nelon, Garima Singh   +2 more
wiley   +1 more source

Linezolid to treat extensively drug-resistant TB:retrospective data are confirmed by experimental evidence

, 2013
Extensively drug-resistant tuberculosis (XDR-TB) on top of being a growing public health concern, represents a nightmare for the clinician. The crucial therapeutic issue is the difficulty of identifying at least four available ‘‘active’’ anti-TB drugs ...
D'Ambrosio, L., Int Grp Study Linezolid, Zampogna, E., Migliori, G.B., Skrahina, A., Villar, M., Alffenaar, J. W. C., Caminero, J. A., Sotgiu, Giovanni, Migliori, Giovanni Battista, Zellweger, J. P., Sotgiu, G., Spanevello, A., Singla, R., De Lorenzo, S., International Group for the study of Linezolid, Shim, T. S., Zumla, A., Schecter, G. F., Centis, R., Koh, W. J., D'Ambrosio, Lia, Udwadia, Z. F., Anger, H. A., Spanevello, Antonio, Centis, Rosella, Migliori, G. B., Castiglia, P., Ferrara, G.   +28 more
core   +1 more source

Antimicrobial susceptibility patterns of Linezolid-resistant coagulase-negative staphylococci in Pakistan

Khyber Medical University Journal
OBJECTIVE: To determine the antimicrobial resistance pattern in Linezolid-resistant coagulase negative staphylococcus (CoNS) isolates in Pakistan. METHODS: This cross-sectional study was conducted from February and July 2022, at a private laboratory in
Arooj Sattar, Namra Mahmood, Zahra Riaz, Iram Yousaf, Rubeena Hafeez, Sakina Jamil   +5 more
doaj   +1 more source