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Drought and heat stress mediated activation of lipid signaling in plants: a critical review [PDF]
Frontiers in Plant Science, 2023 Lipids are a principal component of plasma membrane, acting as a protective barrier between the cell and its surroundings. Abiotic stresses such as drought and temperature induce various lipid-dependent signaling responses, and the membrane lipids ...
Parul Sharma +7 more
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Lipid Signaling in Ocular Neovascularization. [PDF]
Int J Mol Sci, 2020 Vasculogenesis and angiogenesis play a crucial role in embryonic development. Pathological neovascularization in ocular tissues can lead to vision-threatening vascular diseases, including proliferative diabetic retinopathy, retinal vein occlusion ...
Terao R, Kaneko H.
europepmc +6 more sources
Lipid Signaling During Gamete Maturation. [PDF]
Front Cell Dev Biol, 2022 Cell lipids are differentially distributed in distinct organelles and within the leaflets of the bilayer. They can further form laterally defined sub-domains within membranes with important signaling functions.
Mostafa S, Nader N, Machaca K.
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Mitochondrial Lipid Signaling and Adaptive Thermogenesis. [PDF]
Metabolites, 2021 Thermogenesis is an energy demanding process by which endotherms produce heat to maintain their body temperature in response to cold exposure. Mitochondria in the brown and beige adipocytes play a key role in thermogenesis, as the site for uncoupling ...
Von Bank H +3 more
europepmc +2 more sources
Fight Hard or Die Trying: Current Status of Lipid Signaling during Plant-Pathogen Interaction. [PDF]
Plants (Basel), 2021 Plant diseases pose a substantial threat to food availability, accessibility, and security as they account for economic losses of nearly $300 billion on a global scale.
Mehta S +4 more
europepmc +2 more sources
Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways. [PDF]
PLoS Pathog, 2021 Parasitic nematodes cause significant morbidity and mortality globally. Excretory/secretory products (ESPs) such as fatty acid- and retinol- binding proteins (FARs) are hypothesized to suppress host immunity during infection, yet little is known about ...
Parks SC +13 more
europepmc +2 more sources
Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration. [PDF]
Cells, 2020 Cardiovascular disease (CVD) remains a leading cause of death globally. Understanding and characterizing the biochemical context of the cardiovascular system in health and disease is a necessary preliminary step for developing novel therapeutic ...
Wasserman AH, Venkatesan M, Aguirre A.
europepmc +2 more sources
J Cell Sci, 2021 Sortilin is a receptor for neuronal uptake of apolipoprotein E. Sortilin-dependent uptake of lipidated apoE promotes conversion of polyunsaturated fatty acids (PUFA) into neuromodulators that induce anti-inflammatory gene expression in the brain.
Asaro A +11 more
europepmc +2 more sources
Lipid signalling in disease [PDF]
Nature Reviews Molecular Cell Biology, 2008 Signalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids control important cellular processes, including cell proliferation, apoptosis, metabolism and migration. Extracellular signals from cytokines, growth factors and nutrients control the activity of a key set of lipid-modifying enzymes: phospholipases, prostaglandin ...
Matthias P Wymann, Roger Schneiter
exaly +5 more sources
Sphingosine 1-phosphate: Lipid signaling in pathology and therapy. [PDF]
Science, 2019 Mediating systemic health Sphingosine 1-phosphate (S1P) is an important circulating lipid mediator that is derived from the metabolism of cell membranes.
Cartier A, Hla T.
europepmc +2 more sources