Results 21 to 30 of about 6,252,566 (347)

Profiling of fatty acid metabolism in the dorsal root ganglion after peripheral nerve injury

Frontiers in Pain Research, 2022
Peripheral nerve injury (PNI) induces neuronal hyperexcitability, which underlies neuropathic pain. The emergence of RNA sequencing technologies has enabled profiling of transcriptional changes in pathological conditions. However, these approaches do not
Shota Yamamoto, Tomomi Hashidate-Yoshida, Takao Shimizu, Takao Shimizu, Hideo Shindou, Hideo Shindou   +5 more
doaj   +1 more source

Hepatic Levels of DHA-Containing Phospholipids Instruct SREBP1-Mediated Synthesis and Systemic Delivery of Polyunsaturated Fatty Acids

iScience, 2020
Summary: Polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), play fundamental roles in mammalian physiology.
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu   +9 more
doaj   +1 more source

Maternal Transmission of Human OGG1 Protects Mice Against Genetically- and Diet-Induced Obesity Through Increased Tissue Mitochondrial Content

Frontiers in Cell and Developmental Biology, 2021
Obesity and related metabolic disorders are pressing public health concerns, raising the risk for a multitude of chronic diseases. Obesity is multi-factorial disease, with both diet and lifestyle, as well as genetic and developmental factors leading to ...
Natalie Burchat, Priyanka Sharma, Hong Ye, Sai Santosh Babu Komakula, Sai Santosh Babu Komakula, Agnieszka Dobrzyn, Agnieszka Dobrzyn, Vladimir Vartanian, R. Stephen Lloyd, R. Stephen Lloyd, Harini Sampath, Harini Sampath, Harini Sampath   +12 more
doaj   +1 more source

Quantification of Fatty Acids in Mammalian Tissues by Gas Chromatography–Hydrogen Flame Ionization Detection

Bio-Protocol, 2020
In mammalian organisms, fatty acids (FAs) exist mostly in esterified forms, as building blocks of phospholipids, triglycerides, and cholesteryl esters, while some exist as non-esterified free FAs. The absolute quantification of FA species in total lipids
Fumie Hamano, Suzumi Tokuoka, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Yoshihiro Kita   +5 more
doaj   +1 more source

Hypoxia and lipid signaling [PDF]

Biological Chemistry, 2006
AbstractSufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and respond to hypoxia by upregulating the expression of specific genes, which allows an ...
Huwiler, Andrea, Pfeilschifter, Josef
openaire   +4 more sources

Lipid signaling in plants [PDF]

Frontiers in Plant Science, 2013
Membrane lipids provide both the structural basis for cell membranes and a rich source of cellular mediators that regulate many aspects of plant development and environmental interactions. Over recent years, lipids as hormones and signaling messengers have gained increasing attention in the plant biology community.
Wang, Xuemin, Chapman, Kent Dean
openaire   +3 more sources

Comparative Analysis of Phospholipase D (PLD) Gene Family in Camelina sativa and Brassica napus and Its Responses in Camelina Seedlings under Salt Stress

Agronomy, 2023
Phospholipases are among the important elements involved in lipid-dependent cell signaling that lead to the induction of downstream pathways. In the current study, phospholipases D (PLDs) gene family was characterized and compared in two important ...
Parviz Heidari, Fatemeh Puresmaeli, Yavar Vafaee, Mostafa Ahmadizadeh, Mohammadreza Ensani, Haniyeh Ahmadinia   +5 more
doaj   +1 more source

Solution NMR Structure of the SH3 Domain of Human Caskin1 Validates the Lack of a Typical Peptide Binding Groove and Supports a Role in Lipid Mediator Binding

Cells, 2021
SH3 domains constitute an important class of protein modules involved in a variety of cellular functions. They participate in protein-protein interactions via their canonical ligand binding interfaces composed of several evolutionarily conserved aromatic
Orsolya Tőke, Kitti Koprivanacz, László Radnai, Balázs Merő, Tünde Juhász, Károly Liliom, László Buday   +6 more
doaj   +1 more source

Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells

Journal of Lipid Research, 2014
Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 positions, respectively.
Daisuke Hishikawa, Tomomi Hashidate, Takao Shimizu, Hideo Shindou   +3 more
doaj   +1 more source

Plasmalogens and Photooxidative Stress Signaling in Myxobacteria, and How it Unmasked CarF/TMEM189 as the Δ1′-Desaturase PEDS1 for Human Plasmalogen Biosynthesis

Frontiers in Cell and Developmental Biology, 2022
Plasmalogens are glycerophospholipids with a hallmark sn-1 vinyl ether bond that endows them with unique physical-chemical properties. They have proposed biological roles in membrane organization, fluidity, signaling, and antioxidative functions, and ...
S. Padmanabhan, Antonio J. Monera-Girona, Elena Pajares-Martínez, Eva Bastida-Martínez, Irene del Rey Navalón, Ricardo Pérez-Castaño, María Luisa Galbis-Martínez, Marta Fontes, Montserrat Elías-Arnanz   +8 more
doaj   +1 more source