Results 21 to 30 of about 77,919 (340)
Journal of Hematology & Oncology, 2020 BackgroundLong non-coding RNAs (lncRNAs) possess significant regulatory functions in multiple biological and pathological processes, especially in cancer.
X. Zuo +9 more
semanticscholar +1 more source
Serine catabolism generates liver NADPH and supports hepatic lipogenesis
Nature Metabolism, 2021 Carbohydrate can be converted into fat by de novo lipogenesis, a process upregulated in fatty liver disease. Chemically, de novo lipogenesis involves polymerization and reduction of acetyl-CoA, using NADPH as the electron donor.
Zhaoyue Zhang +8 more
semanticscholar +1 more source
FASN-dependent de novo lipogenesis is required for brain development
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Regulation of cellular metabolism in proliferating progenitor cells and their neuronal progeny is critical for brain development and function.
Daniel Gonzalez-Bohorquez +6 more
semanticscholar +1 more source
Veterinary Sciences, 2022 Optimal combinations of essential oils (EOs) can enhance performance and maintain poultry productivity. The effects of EOs with black pepper oil (BPO) or radish seed oil (RSO) on performance and the expression of digestive enzymes, lipogenesis, immunity,
Asmaa T. Y. Kishawy +7 more
doaj +1 more source
ATF6 modulates SREBP2-mediated lipogenesis [PDF]
The EMBO Journal, 2004 Activating transcription factor 6 (ATF6) and sterol regulatory element-binding proteins (SREBPs) are activated by proteolytic cleavage. The ensuing nuclear translocation of their N-termini (i.e., ATF6(N) and SREBP(N)) activates the respective target genes involved in unfolded protein response and lipogenesis.
Zeng, L +6 more
openaire +4 more sources
Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer
Pharmaceuticals, 2020 Uncontrolled proliferation is a feature defining cancer and it is linked to the ability of cancer cells to effectively adapt their metabolic needs in response to a harsh tumor environment.
Barbara Guerra, Olaf-Georg Issinger
doaj +1 more source
Expression of STING in Women with Morbid Obesity and Nonalcoholic Fatty Liver Disease
Metabolites, 2023 Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic hepatic disease. Although mostly benign, this disease can evolve into nonalcoholic steatohepatitis (NASH).
Laia Bertran +11 more
doaj +1 more source
Journal of Lipid Research, 1984 In rat hepatocytes freshly isolated from donor rats at different times of the day, the rates of lipogenesis (de novo fatty acid synthesis) varied with a diurnal periodicity.
G F Gibbons +2 more
doaj +1 more source
PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice
Frontiers in Endocrinology, 2023 IntroductionMultiple factors can contribute to sub-fecundity, including genetics, lifestyle, and environmental contaminants. PFASs are characterized as “forever chemicals” due to their ubiquitous contamination and their persistence in the environment ...
Wang Ka Lee +7 more
doaj +1 more source
Fructose stimulated de novo lipogenesis is promoted by inflammation
Nature Metabolism, 2020 Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation.
Jelena Todoric +25 more
semanticscholar +1 more source