Results 51 to 60 of about 75,579 (341)
Frontiers in Molecular Biosciences, 2023 MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice.
Gilles Willemin +8 more
doaj +1 more source
Role of Lipogenesis Rewiring in Hepatocellular Carcinoma
Seminars in liver disease (Print), 2021 Metabolic rewiring is one of the hallmarks of cancer. Altered de novo lipogenesis is one of the pivotal metabolic events deregulated in cancers. Sterol regulatory element-binding transcription factor 1 (SREBP1) controls the transcription of major enzymes
Yi Zhou, J. Tao, D. Calvisi, Xin Chen
semanticscholar +1 more source
Frontiers in Oncology, 2022 USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13
Juhong Wang +21 more
doaj +1 more source
Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
Nutrients, 2018 De novo lipogenesis (DNL) is a complex and highly regulated process in which carbohydrates from circulation are converted into fatty acids that are then used for synthesizing either triglycerides or other lipid molecules. Dysregulation of DNL contributes
Ziyi Song, A. Xiaoli, Fajun Yang
semanticscholar +1 more source
The role of fibroblast growth factors in cell and cancer metabolism
FEBS Letters, EarlyView.Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source
Lipids in Health and DiseaseBackground Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic liver disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However,
Zhouqi Wang +6 more
doaj +1 more source
Lack of adaptation in lipogenesis by hepatoma 9121
Journal of Lipid Research, 1968 The “minimal deviation” hepatoma 9121, implanted in rats, was shown to biosynthesize fatty acids from acetate-l-14C at the same rate as normal rat liver but faster than host liver.
J.C. Elwood, Harold P. Morris
doaj +1 more source
Frontiers in Endocrinology, 2022 BackgroundFGF21 pharmacological treatment reverses fatty liver and lowers serum triglyceride concentration but FGF21 serum level is increased in hepatic steatosis.
Ewa Szczepańska +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao +7 more
wiley +1 more source