Results 51 to 60 of about 77,919 (340)

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Nature Communications, 2020
Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance.
K. Roumans, L. Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, E. Phielix, B. Havekes, Y. Bruls, M. Brouwers, M. Ståhlman, M. Alssema, H. Peters, R. de Mutsert, B. Staels, M. Taskinen, J. Borén, P. Schrauwen, V. Schrauwen-Hinderling   +16 more
semanticscholar   +1 more source

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

The Deubiquitinase USP13 Maintains Cancer Cell Stemness by Promoting FASN Stability in Small Cell Lung Cancer

Frontiers in Oncology, 2022
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13
Juhong Wang, Juhong Wang, Weihao Lin, Weihao Lin, Renda Li, Renda Li, Hong Cheng, Hong Cheng, Sijin Sun, Sijin Sun, Fei Shao, Yannan Yang, Yannan Yang, Lin Zhang, Lin Zhang, Xiaoli Feng, Shugeng Gao, Yibo Gao, Yibo Gao, Yibo Gao, Jie He, Jie He   +21 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA

Lipids in Health and Disease
Background Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic liver disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However,
Zhouqi Wang, Xinxing Wan, Md Asaduzzaman Khan, Lin Peng, Xiaoying Sun, Xuan Yi, Ke Chen   +6 more
doaj   +1 more source

Lack of adaptation in lipogenesis by hepatoma 9121

Journal of Lipid Research, 1968
The “minimal deviation” hepatoma 9121, implanted in rats, was shown to biosynthesize fatty acids from acetate-l-14C at the same rate as normal rat liver but faster than host liver.
J.C. Elwood, Harold P. Morris
doaj   +1 more source

FGF21 Is Released During Increased Lipogenesis State Following Rapid-Onset Radioiodine-Induced Hypothyroidism

Frontiers in Endocrinology, 2022
BackgroundFGF21 pharmacological treatment reverses fatty liver and lowers serum triglyceride concentration but FGF21 serum level is increased in hepatic steatosis.
Ewa Szczepańska, Piotr Glinicki, Wojciech Zgliczyński, Jadwiga Słowińska-Srzednicka, Helena Jastrzębska, Małgorzata Gietka-Czernel   +5 more
doaj   +1 more source

Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues

Nutrients, 2018
De novo lipogenesis (DNL) is a complex and highly regulated process in which carbohydrates from circulation are converted into fatty acids that are then used for synthesizing either triglycerides or other lipid molecules. Dysregulation of DNL contributes
Ziyi Song, A. Xiaoli, Fajun Yang
semanticscholar   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source