Results 101 to 110 of about 40,812 (258)

Synergistic Effect of Quercetin and α-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats

Journal of Toxicology, 2018
Objectives. The present study was carried out to study the protective effects of quercetin and α-lipoic acid alone and in combination against aluminum chloride induced neurotoxicity in rats. Materials and Methods.
Sooad Saud Al-Otaibi, Maha Mohamad Arafah, Bechan Sharma, Abdullah Salih Alhomida, Nikhat Jamal Siddiqi   +4 more
doaj   +1 more source

Genome-wide analysis of 30 -untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes [PDF]

, 2013
In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their ...
Agüero, Fernan Gonzalo, Carmona, Santiago Javier, de Gaudenzi, Javier Gerardo, Frasch, Alberto Carlos C.   +3 more
core   +3 more sources

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial [PDF]

, 2013
Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes. The aim of this study was to evaluate the inositol and alpha lipoic acid combination effectiveness on ...
Botti, Gerardo, Brillante, Giuseppe, Capasso, Immacolata, Cavalcanti, Ernesta, CILIBERTO, GENNARO, CRISPO, ANNA, D'Aiuto, Giuseppe, D'Aiuto, Massimiliano, DE LAURENTIIS, MICHELINO, ESPOSITO, EMANUELA, Esposito, Giuseppe, Frasci, Giuseppe, Fucito, Alfredo, Grimaldi, Maria, Maurea, Nicola, Montella, Maurizio   +15 more
core   +1 more source

Efficacy and Safety of Pregabalin and Alpha‐Lipoic Acid Combination in Patients With Painful Diabetic Peripheral Neuropathy: A Randomized, Open‐Label, Non‐Inferiority, Phase IV Clinical Trial and Subgroup Analysis (OPTIMUM Study)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess the efficacy and safety of alpha‐lipoic acid (ALA) and pregabalin, both as mono and combination therapy, for treating painful diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus, with the hypothesis that pregabalin monotherapy is non‐inferior to combination therapy.
Tae Jung Oh, Sang Soo Kim, Seung‐Hwan Lee, Hyuk‐Sang Kwon, Eun Sook Kim, Eun‐Jung Rhee, Hye Jin Yoo, Han Na Jang, Woo Je Lee, Eun Sook Kim, Sang Yong Kim, Gwanpyo Koh, Eun‐Gyoung Hong, Tae Sun Park, Jong Chul Won   +14 more
wiley   +1 more source

Reduction of a-tocopherylquinone Model Compound With Various Reductant [PDF]

, 2001
In order to study the possibility of tranformation of a-tocopherylquinone (TQ) into a more oxidiseable compound and also to find out the recycling effect in the cells, an experiment was conducted by reducing the model compound 2-(3- hydroxy-3-methylbutyl)
Kohar, Indrajati
core  

Antioxidant, phase II and III responses induced by lipoic acid in the fish Jenynsia multidentata (Anablapidae) and its influence on endolsulfan accumulation and toxicity [PDF]

, 2013
Antioxidants like lipoic acid (LA) are known to trigger augmented antioxidant and phase II and III responses. This study aimed to evaluate the effect of LA in P-glycoprotein (Pgp) expression, glutathione-S-transferase (GST) activity, total ...
Amé, María Valeria, Ballesteros, Maria Laura, Garcia, M. L., Gonzalez, Mariana, Miglioranza, Karina Silvia Beatriz, Monserrat, José María, Ventura Lima, J., Wunderlin, Daniel Alberto   +7 more
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study

Scientific Reports, 2017
High-fat diet (HFD)-induced obesity is accompanied by insulin resistance and compromised brain synaptic plasticity through the impairment of insulin-sensitive pathways regulating neuronal survival, learning, and memory.
Zhigang Liu, Ishan Patil, Harsh Sancheti, Fei Yin, Enrique Cadenas   +4 more
doaj   +1 more source

The Effect of Alpha Lipoic Acid in Preventing Atherosclerosis Lesion on the Abdominal Aorta of Diabetes Mellitus Type 2 Rats [PDF]

, 2017
Various studies have studied the clinical use of alpha-lipoic acid (ALA) for treating diabetic complications. The protective effect of  lipoic acid in  atherosclerosis induced by diabetes mellitus type 2 (DM type 2)  still needs further ...
ismawati, I. (Ismawati), Sembiring, L. P. (Ligat)   +1 more
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