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Lipoic Acid Based Redox-Responsive Degradable Antimicrobial Polymers. [PDF]
Macromol Rapid CommunGiri A +7 more
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Huber Proprioceptive Training and Alpha-Lipoic Acid: A New Approach in Optimizing Nerve Function in Patients With Chronic Low Back Pain. [PDF]
CureusKadrić A +8 more
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The pharmacology of the antioxidant lipoic acid
General Pharmacology, 1997 1. Lipoic acid is an example of an existing drug whose therapeutic effect has been related to its antioxidant activity. 2. Antioxidant activity is a relative concept: it depends on the kind of oxidative stress and the kind of oxidizable substrate (e.g., DNA, lipid, protein). 3.
Guido Haenen, Aalt Bast
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Lipoic acid: A multifunctional antioxidant
BioFactors, 2003 Lipoic acid: a multifunctional ...
Bast, A., Haenen, G.R.M.M.
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Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy
Expert Review of Clinical Pharmacology, 2014The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix, ultimately functioning to control these metabolic ...
Paul M, Bingham +2 more
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Electrochemical Determination of Lipoic Acid [PDF]
Journal of Analytical Chemistry, 2004 Procedures for determining lipoic acid by voltammetry and coulometric titration with electrogenerated halogens using the biamperometric indication of the titration end-point were developed. Possible mechanisms of lipoic acid oxidation with electrogenerated halogens are discussed.
Ziyatdinova G. +2 more
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Reduction of lipoic acid by lipoamide dehydrogenase
Biochemical Pharmacology, 1996 Racemic lipoic acid is therapeutically applied in pathologies in which free radicals are involved. The in vivo reduction of lipoic acid may play an essential role in its antioxidant effect.
Guido Haenen, Aalt Bast
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Lipoic acid metabolism in the rat
Archives of Biochemistry and Biophysics, 1976Abstract dl-[1,6-14C]Lipoic acid was administered by intraperitoneal injection to rats at the level of 0.5 mg/100 g body weight. Approximately 56% of the radioactivity was recovered in the urine. When acidified and extracted with benzene, 92% of the radioactivity remained in the aqueous phase.
J T, Spence, D B, McCormick
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Multifunctional Lipoic Acid Conjugates
Current Medicinal Chemistry, 2009Several hundreds of studies published the last decade have reported that alpha-lipoic acid (LA) possess the potential to intervene in various therapeutically interesting pathways. However, it should be noted that LA reportedly exerts most of its effects at high micromolar concentrations; that amides of LA exhibit higher biological activity than the ...
Koufaki, Maria, Detsi, A., Kiziridi, C.
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Journal of Agricultural and Food Chemistry, 1994
Lipoic acid was found to be present at low levels in wheat germ (ca. 0.1 ppm) but was not detected in flour or semolina. The reduced form of lipoic acid provided the reducing equivalents for thioredoxin in the reduction of proteins of wheat endosperm (albumins, globulins, gliadins, and glutenins).
Vianey-Liaud, N. +4 more
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Lipoic acid was found to be present at low levels in wheat germ (ca. 0.1 ppm) but was not detected in flour or semolina. The reduced form of lipoic acid provided the reducing equivalents for thioredoxin in the reduction of proteins of wheat endosperm (albumins, globulins, gliadins, and glutenins).
Vianey-Liaud, N. +4 more
openaire +2 more sources