Results 101 to 110 of about 144,905 (388)
Glucocorticoids increase basal lipolysis, but not epinephrine stimulated lipolysis
The FASEB Journal, 2009 Glucocorticoids (GCs) are associated with central obesity, yet have been classically defined as lipolytic. We have recently shown that exercise training decreases fat mass while increasing GC action in adipocytes, perhaps by increasing adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL).
Thomas J. Hawke +2 more
openaire +2 more sources
Advanced Science, EarlyView.ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma +9 more
wiley +1 more source
Regulation and Functions of Autophagic Lipolysis [PDF]
Trends in Endocrinology & Metabolism, 2016 The selective breakdown by autophagy of lipid droplet (LD)-stored lipids, termed lipophagy, is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral lipases. The physiological importance of lipophagy has been demonstrated in multiple mammalian cell types, as well as in lower organisms, and this pathway has many functions in ...
Francesca Cingolani, Mark J. Czaja
openaire +3 more sources
Advanced Science, EarlyView.This review first summarizes the complex pathogenesis of atherosclerosis and outlines the limitations of conventional therapies. It then explores innovative nanoparticle drug delivery system (NDDS) developments, detailing their precision targeting strategies, responsiveness to plaque‐specific stimuli, modulation of key pathological processes, and ...
Yunqi Zhang +13 more
wiley +1 more source
Frontiers in Endocrinology, 2022 Epidemic obesity is contributing to increases in the prevalence of obesity-related metabolic diseases and has, therefore, become an important public health problem.
Xi-Ding Yang +5 more
doaj +1 more source
Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]
, 2018 Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core +2 more sources
Lipolysis Control: The Plot Thickens [PDF]
Cell Metabolism, 2010 The complex process of lipolysis mobilizes fatty acids from adipocyte triglyceride stores for energy production in muscle and other organs during fasting and exercise. In this issue of Cell Metabolism, Yang, et al. identify G0S2 as a regulator of the key enzyme, adipose triglyceride lipase.
openaire +3 more sources
From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies
Advanced Science, EarlyView.This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen +7 more
wiley +1 more source
European Journal of Preventive Cardiology, 2019 Background Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-
Ma Feng +24 more
semanticscholar +1 more source
Genomic Insights into the Origin, High Fecundity and Environmental Adaptation of Hu Sheep
Advanced Science, EarlyView.The Hu sheep diverged from the Small‐tailed Han sheep ≈1330 years ago, and subsequently migrated from northern to warm and humid southern regions. The genes BMPR1B, UNC5C, and GRID2 play a synergistic role in the superior reproductive traits of Hu sheep.
Zexuan Liu +12 more
wiley +1 more source