Results 31 to 40 of about 86,531 (200)
Molecular Metabolism, 2020 Objectives: Lipolysis, hydrolysis of triglycerides to fatty acids in adipocytes, is tightly regulated, poorly understood, and, if perturbed, can lead to metabolic diseases including obesity and type 2 diabetes.
Agné Kulyté +8 more
doaj
Mljekarstvo, 2015 The aim of this study was to evaluate in detail the relationship between the basic milk components (fat and protein percentage) and the free fatty acids (FFA) content, as indicators of spontaneous and/or induced lipolysis. The additional aim of the study
Luděk Stádník +5 more
doaj +1 more source
Alterations of the Lipid Metabolome in Dairy Cows Experiencing Excessive Lipolysis Early Postpartum. [PDF]
PLoS ONE, 2016 A decrease in insulin sensitivity enhances adipose tissue lipolysis helping early lactation cows counteracting their energy deficit. However, excessive lipolysis poses serious health risks for cows, and its underlying mechanisms are not clearly ...
Elke Humer +4 more
doaj +1 more source
Trichostatin A modulates thiazolidinedione-mediated suppression of tumor necrosis factor α-induced lipolysis in 3T3-L1 adipocytes. [PDF]
PLoS ONE, 2013 In obesity, high levels of tumor necrosis factor α (TNFα) stimulate lipolysis in adipocytes, leading to hyperlipidemia and insulin resistance. Thiazolidinediones (TZDs), the insulin-sensitizing drugs, antagonize TNFα-induced lipolysis in adipocytes ...
Juu-Chin Lu +5 more
doaj +1 more source
Lipids in Health and Disease, 2018 Cancer cachexia is a progressive and multi-factorial metabolic syndrome characterized by loss of adipose tissue and skeletal muscle. White adipose tissue (WAT) lipolysis and white-to-brown transdifferentiation of WAT (WAT browning) are proposed to ...
Jun Han, Q. Meng, Lei Shen, Guohao Wu
semanticscholar +1 more source
Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice. [PDF]
PLoS ONE, 2013 Adipose tissue expressed endogenous cystathionine gamma lyase (CSE)/hydrogen sulfide (H2S) system. H2S precursor inhibited catecholamine stimulated lipolysis.
Bin Geng +10 more
doaj +1 more source
Frontiers in Oncology, 2022 Adipose tissue inflammation is observed in multiple metabolically-altered states including cancer-associated cachexia and obesity. Although cachexia is a syndrome of adipose loss and obesity is a disease of adipose excess, both pathologies demonstrate ...
Aakash Y. Gandhi +14 more
doaj +1 more source
Scientific Reports, 2018 Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR).
K. Verboven +11 more
semanticscholar +1 more source
Shared genetic loci for body fat storage and adipocyte lipolysis in humans
Scientific Reports, 2022 Total body fat and central fat distribution are heritable traits and well-established predictors of adverse metabolic outcomes. Lipolysis is the process responsible for the hydrolysis of triacylglycerols stored in adipocytes.
Agné Kulyté +4 more
doaj +1 more source
Nature Cell Biology, 2015 Chaperone-mediated autophagy (CMA) selectively degrades a subset of cytosolic proteins in lysosomes. A potent physiological activator of CMA is nutrient deprivation, a condition in which intracellular triglyceride stores or lipid droplets (LDs) also ...
Susmita Kaushik, A. Cuervo
semanticscholar +1 more source